Atualizações no tratamento farmacológico da doença de Parkinson Article Swipe

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Camille Esteves Chermont , Luana Mariano Monteiro , Rafael Lopes de Sena , Elyenayra Nogueira Pinheiro , Edwin Gabriel Avella Faura , Rita de Cássia Silva de Oliveira ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.25248/reas.e20697.2025

Objetivo: Revisar atualizações farmacológicas para a Doença de Parkinson (DP). Métodos: Foi realizada uma busca nas bases de dados LILACS, PubMED e SciELO utilizando descritores atrelados ao Parkinson e farmacoterapia. Resultados: Foram incluídos 9 estudos de 10 países com uma amostra total de 1.986 participantes. Identificou-se que a DP já possui um tratamento bem consolidado, sendo a Levodopa a droga padrão-ouro. Porém, devido a pré-disposição cada vez maior de pessoas para a doença e seus efeitos adversos no estado emocional e psiquiátrico, novos potenciais medicamentos como zonisamida, safinamida, IMAO-B, rivastigmina, Origanum majorana, grânulos de Pingchan estão sendo estudados para promover maior independência e qualidade de vida dos pacientes, visto que podem melhorar os sintomas motores, mas principalmente os sintomas não motores. Estes fármacos potenciais podem vir como terapia adjuvante a levodopa. Considerações finais: Apesar da Levodopa ser a droga de escolha no tratamento da DP novas substâncias químicas têm se destacado na farmacoterapia alternativa para tratar, principalmente, os sintomas psiquiátricos da doença, possibilitando melhoria da qualidade de vida dos pacientes. Dessarte, mais estudos devem ser conduzidos para embasar e fortalecer a medicina baseada em evidências na DP.

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Parkinson's disease Medicine Disease Internal medicine

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Type: article
Language: pt
Landing Page: https://doi.org/10.25248/reas.e20697.2025
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DOI: https://doi.org/10.25248/reas.e20697.2025

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Title: Atualizações no tratamento farmacológico da doença de Parkinson

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Language: pt

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Publication year: 2025

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Publication date: 2025-06-13

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Authors: Camille Esteves Chermont, Luana Mariano Monteiro, Rafael Lopes de Sena, Elyenayra Nogueira Pinheiro, Edwin Gabriel Avella Faura, Rita de Cássia Silva de Oliveira

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Landing page: https://doi.org/10.25248/reas.e20697.2025

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Concepts: Parkinson's disease, Medicine, Disease, Internal medicine

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