Augmentation of Limb Perfusion and Reversal of Tissue Ischemia Produced by Ultrasound-Mediated Microbubble Cavitation Article Swipe
J. Todd Belcik
,
Brian Mott
,
Aris Xie
,
Yan Zhao
,
Sajeevani Kim
,
Nathan J. Lindner
,
Azzdine Y. Ammi
,
Joel Linden
,
Jonathan R. Lindner
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1161/circimaging.114.002979
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1161/circimaging.114.002979
Background— Ultrasound can increase tissue blood flow, in part, through the intravascular shear produced by oscillatory pressure fluctuations. We hypothesized that ultrasound-mediated increases in perfusion can be augmented by microbubble contrast agents that undergo ultrasound-mediated cavitation and sought to characterize the biological mediators. Methods and Results— Contrast ultrasound perfusion imaging of hindlimb skeletal muscle and femoral artery diameter measurement were performed in nonischemic mice after unilateral 10-minute exposure to intermittent ultrasound alone (mechanical index, 0.6 or 1.3) or ultrasound with lipid microbubbles (2×10 8 IV). Studies were also performed after inhibiting shear- or pressure-dependent vasodilator pathways, and in mice with hindlimb ischemia. Ultrasound alone produced a 2-fold increase ( P <0.05) in muscle perfusion regardless of ultrasound power. Ultrasound-mediated augmentation in flow was greater with microbubbles (3- and 10-fold higher than control for mechanical index 0.6 and 1.3, respectively; P <0.05), as was femoral artery dilation. Inhibition of endothelial nitric oxide synthase attenuated flow augmentation produced by ultrasound and microbubbles by 70% ( P <0.01), whereas inhibition of adenosine-A 2a receptors and epoxyeicosatrienoic acids had minimal effect. Limb nitric oxide production and muscle phospho-endothelial nitric oxide synthase increased in a stepwise fashion by ultrasound and ultrasound with microbubbles. In mice with unilateral hindlimb ischemia (40%–50% reduction in flow), ultrasound (mechanical index, 1.3) with microbubbles increased perfusion by 2-fold to a degree that was greater than the control nonischemic limb. Conclusions— Increases in muscle blood flow during high-power ultrasound are markedly amplified by the intravascular presence of microbubbles and can reverse tissue ischemia. These effects are most likely mediated by cavitation-related increases in shear and activation of endothelial nitric oxide synthase.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1161/circimaging.114.002979
- https://www.ahajournals.org/doi/pdf/10.1161/CIRCIMAGING.114.002979
- OA Status
- bronze
- Cited By
- 109
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2085123717
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2085123717Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1161/circimaging.114.002979Digital Object Identifier
- Title
-
Augmentation of Limb Perfusion and Reversal of Tissue Ischemia Produced by Ultrasound-Mediated Microbubble CavitationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-04-01Full publication date if available
- Authors
-
J. Todd Belcik, Brian Mott, Aris Xie, Yan Zhao, Sajeevani Kim, Nathan J. Lindner, Azzdine Y. Ammi, Joel Linden, Jonathan R. LindnerList of authors in order
- Landing page
-
https://doi.org/10.1161/circimaging.114.002979Publisher landing page
- PDF URL
-
https://www.ahajournals.org/doi/pdf/10.1161/CIRCIMAGING.114.002979Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.ahajournals.org/doi/pdf/10.1161/CIRCIMAGING.114.002979Direct OA link when available
- Concepts
-
Microbubbles, Ultrasound, Medicine, Perfusion, Mechanical index, Hindlimb, Femoral artery, Limb perfusion, Blood flow, Vasodilation, Ischemia, Nitric oxide, Internal medicine, Cardiology, Anatomy, RadiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
109Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 17, 2023: 10, 2022: 11, 2021: 19Per-year citation counts (last 5 years)
- References (count)
-
29Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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