Augmented EPR Effect Post IRFA to Enhance the Therapeutic Efficacy of Arsenic Loaded ZIF-8 Nanoparticles on Residual HCC Progression Article Swipe
Xuehua Chen
,
Hao Wang
,
Hui Chen
,
Ziman Chen
,
Jiaxin Chen
,
Yongquan Huang
,
Dan Li
,
Zhongzhen Su
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-855966/v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-855966/v1
BackgroundInsufficient radiofrequency ablation (IRFA) can promote the local recurrence and distal metastasis of residual hepatocellular carcinoma (HCC), which makes clinical treatment extremely challenging. In this study, the malignant transition of residual tumors after IRFA was explored. Then, arsenic-loaded zeolitic imidazolate framework-8 nanoparticles (As@ZIF-8 NPs) were constructed, and their therapeutic effect on residual tumors was studied. ResultsOur data showed that IRFA can dramatically promote the proliferation, induce the metastasis, activate the epithelial-mesenchymal transition (EMT) and accelerate the angiogenesis of residual tumors. Interestingly, we found, for the first time, that extensive angiogenesis after IRFA can augment the enhanced permeability and retention (EPR) effect and enhance the enrichment of ZIF-8 nanocarriers in residual tumors. Encouraged by this unique finding, we successfully prepared As@ZIF-8 NPs with good biocompatibility and confirmed that they were more effective than free arsenic trioxide (ATO) in sublethal heat-induced cell proliferation suppression, apoptosis induction, cell migration and invasion inhibition, and EMT reversal in vitro . Furthermore, compared with free ATO, As@ZIF-8 NPs exhibited remarkably increased therapeutic effects by repressing residual tumor growth and metastasis in vivo .ConclusionsThis work provides a new paradigm for the treatment of residual HCC after IRFA.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-855966/v1
- OA Status
- green
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4235500281
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4235500281Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-855966/v1Digital Object Identifier
- Title
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Augmented EPR Effect Post IRFA to Enhance the Therapeutic Efficacy of Arsenic Loaded ZIF-8 Nanoparticles on Residual HCC ProgressionWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-09-02Full publication date if available
- Authors
-
Xuehua Chen, Hao Wang, Hui Chen, Ziman Chen, Jiaxin Chen, Yongquan Huang, Dan Li, Zhongzhen SuList of authors in order
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https://doi.org/10.21203/rs.3.rs-855966/v1Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.21203/rs.3.rs-855966/v1Direct OA link when available
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Nanoparticle, Cancer research, Nanotechnology, Chemistry, Medicine, Materials scienceTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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31Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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