Aumento da eficácia da inativação fotodinâmica pela incorporação de fotossensibilizador induzida por luz em <i>Candida Albicans</i> Article Swipe
Renan Arnon Romano
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.11606/d.76.2016.tde-21102016-103320
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.11606/d.76.2016.tde-21102016-103320
\n Devido à grande preocupação com a geração de novas tecnologias mais ágeis, eficientes e de baixo custo, as reações fotodinâmicas (RF) têm ganhado destaque. Estas envolvem a ativação de um fármaco fotossensível (fotossensibilizador (FS)), pela iluminação em uma faixa específica de comprimentos de onda, gerando assim espécies reativas altamente citotóxicas levando as células à morte. As RF são divididas em duas categorias: terapia fotodinâmica (TFD) e inativação fotodinâmica (IFD). A primeira é utilizada para tratamentos oncológicos, dermatológicos, entre outros. A segunda é utilizada para descontaminação de micro-organismos em infecções localizadas. Atualmente a IFD tem sido alvo de muitos estudos pois tem diversas vantagens quando comparadas com as técnicas de descontaminação atuais. Duas das mais importantes são: a seletividade e a não geração de micro-organismos resistentes aos FSs. Apesar desta técnica ser utilizada com sucesso em diversos campos, ela ainda apresenta baixa eficiência quando comparada às técnicas tradicionais. Neste contexto, o objetivo deste trabalho foi criar um novo protocolo de aplicação da IFD visando o aumento de eficiência, bem como um estudo profundo das interações dos FSs com as células, e o monitoramento da dinâmica do FS nestas. O presente estudo utiliza-se de células da levedura Candida albicans e demonstra a interação destas células com dois FSs: Photogem® e Curcumina. Foi proposto um novo protocolo que promove o aumento da internalização de FS pelas células baseado na pré-iluminação de baixa dose durante o tempo de incubação. Foi possível demonstrar através da medida dos espectros de absorção do sobrenadante de uma solução com células e Photogem®, que as amostras que tiveram pré-iluminação internalizaram mais FS do meio do que as células mantidas no escuro. Além disso, a partir de ensaios de viabilidade com a levedura e o Photogem® foi demonstrado que as amostras que tiveram pré-iluminação apresentaram diminuição de até seis ordens de grandeza nas unidades formadoras de colônia quando comparadas com as amostras tratadas pelo protocolo tradicional de IFD. Através das técnicas de microscopia confocal de fluorescência e de imagem de tempo de vida de fluorescência foi possível compreender a interação entre os FSs e as células, bem como estudar a ligação deste FS em diferentes regiões da célula. Além disso, foi estudada ainda a mobilidade destas moléculas dentro das células sob condições com e sem iluminação de baixa dose. Através deste estudo pôde-se inferir que as moléculas de curcumina tem tempos característicos de entrada nas células mais lentos que os tempos característicos do Photogem®. Ainda foi possível tomar vantagem da fluorescência do Photogem® para monitorar a entrada deste nas células de levedura, bem como monitorar a formação do seu fotoproduto, determinando assim que 7,5 minutos é o tempo médio de iluminação durante a incubação com FS necessário para que pelo menos 80% das células tivessem o FS internalizado, sem significante formação de fotoprodutos. Conclui-se ainda que este novo protocolo de incubação com iluminação leva a maior eficiência e seletividade da IFD, abrindo caminho para uma nova linha de pesquisa nas RF em geral, possivelmente podendo este protocolo ser aplicado em diversos tipos de células.\n
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Metadata
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- Language
- pt
- Landing Page
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- http://www.teses.usp.br/teses/disponiveis/76/76132/tde-21102016-103320/publico/RenanArnonRomano_ME_corrigida.pdf
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https://doi.org/10.11606/d.76.2016.tde-21102016-103320Digital Object Identifier
- Title
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Aumento da eficácia da inativação fotodinâmica pela incorporação de fotossensibilizador induzida por luz em <i>Candida Albicans</i>Work title
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dissertationOpenAlex work type
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ptPrimary language
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2016Year of publication
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2016-11-28Full publication date if available
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Renan Arnon RomanoList of authors in order
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https://doi.org/10.11606/d.76.2016.tde-21102016-103320Publisher landing page
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https://www.teses.usp.br/teses/disponiveis/76/76132/tde-21102016-103320/publico/RenanArnonRomano_ME_corrigida.pdfDirect link to full text PDF
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goldOpen access status per OpenAlex
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https://www.teses.usp.br/teses/disponiveis/76/76132/tde-21102016-103320/publico/RenanArnonRomano_ME_corrigida.pdfDirect OA link when available
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| abstract_inverted_index.(IFD). | 69 |
| abstract_inverted_index.Apesar | 128 |
| abstract_inverted_index.Devido | 1 |
| abstract_inverted_index.custo, | 17 |
| abstract_inverted_index.dentro | 368 |
| abstract_inverted_index.destas | 202, 366 |
| abstract_inverted_index.disso, | 274, 360 |
| abstract_inverted_index.estudo | 171, 190, 382 |
| abstract_inverted_index.geral, | 493 |
| abstract_inverted_index.grande | 3 |
| abstract_inverted_index.imagem | 329 |
| abstract_inverted_index.lentos | 398 |
| abstract_inverted_index.medida | 241 |
| abstract_inverted_index.morte. | 55 |
| abstract_inverted_index.muitos | 98 |
| abstract_inverted_index.médio | 439 |
| abstract_inverted_index.ordens | 300 |
| abstract_inverted_index.partir | 276 |
| abstract_inverted_index.quando | 104, 143, 308 |
| abstract_inverted_index.tempos | 391, 401 |
| abstract_inverted_index.Candida | 196 |
| abstract_inverted_index.abrindo | 482 |
| abstract_inverted_index.atuais. | 111 |
| abstract_inverted_index.aumento | 165, 218 |
| abstract_inverted_index.baseado | 225 |
| abstract_inverted_index.caminho | 483 |
| abstract_inverted_index.campos, | 137 |
| abstract_inverted_index.durante | 231, 442 |
| abstract_inverted_index.ensaios | 278 |
| abstract_inverted_index.entrada | 394, 417 |
| abstract_inverted_index.escuro. | 272 |
| abstract_inverted_index.estudar | 349 |
| abstract_inverted_index.estudos | 99 |
| abstract_inverted_index.ganhado | 23 |
| abstract_inverted_index.gerando | 45 |
| abstract_inverted_index.inferir | 384 |
| abstract_inverted_index.levando | 51 |
| abstract_inverted_index.minutos | 435 |
| abstract_inverted_index.nestas. | 187 |
| abstract_inverted_index.outros. | 79 |
| abstract_inverted_index.podendo | 495 |
| abstract_inverted_index.promove | 216 |
| abstract_inverted_index.segunda | 81 |
| abstract_inverted_index.sucesso | 134 |
| abstract_inverted_index.terapia | 63 |
| abstract_inverted_index.tiveram | 259, 293 |
| abstract_inverted_index.visando | 163 |
| abstract_inverted_index.ágeis, | 12 |
| abstract_inverted_index.Através | 319, 380 |
| abstract_inverted_index.albicans | 197 |
| abstract_inverted_index.amostras | 257, 291, 312 |
| abstract_inverted_index.aplicado | 499 |
| abstract_inverted_index.através | 239 |
| abstract_inverted_index.colônia | 307 |
| abstract_inverted_index.confocal | 324 |
| abstract_inverted_index.célula. | 358 |
| abstract_inverted_index.células | 53, 193, 203, 224, 252, 269, 370, 396, 420, 454 |
| abstract_inverted_index.diversas | 102 |
| abstract_inverted_index.diversos | 136, 501 |
| abstract_inverted_index.envolvem | 26 |
| abstract_inverted_index.estudada | 362 |
| abstract_inverted_index.fármaco | 31 |
| abstract_inverted_index.grandeza | 302 |
| abstract_inverted_index.levedura | 195, 283 |
| abstract_inverted_index.mantidas | 270 |
| abstract_inverted_index.objetivo | 151 |
| abstract_inverted_index.pesquisa | 489 |
| abstract_inverted_index.presente | 189 |
| abstract_inverted_index.primeira | 71 |
| abstract_inverted_index.profundo | 172 |
| abstract_inverted_index.proposto | 211 |
| abstract_inverted_index.pôde-se | 383 |
| abstract_inverted_index.reativas | 48 |
| abstract_inverted_index.regiões | 356 |
| abstract_inverted_index.tivessem | 455 |
| abstract_inverted_index.trabalho | 153 |
| abstract_inverted_index.tratadas | 313 |
| abstract_inverted_index.técnica | 130 |
| abstract_inverted_index.unidades | 304 |
| abstract_inverted_index.vantagem | 409 |
| abstract_inverted_index.altamente | 49 |
| abstract_inverted_index.apresenta | 140 |
| abstract_inverted_index.comparada | 144 |
| abstract_inverted_index.contexto, | 149 |
| abstract_inverted_index.curcumina | 389 |
| abstract_inverted_index.células, | 179, 346 |
| abstract_inverted_index.demonstra | 199 |
| abstract_inverted_index.destaque. | 24 |
| abstract_inverted_index.dinâmica | 184 |
| abstract_inverted_index.divididas | 59 |
| abstract_inverted_index.espectros | 243 |
| abstract_inverted_index.espécies | 47 |
| abstract_inverted_index.geração | 7, 122 |
| abstract_inverted_index.levedura, | 422 |
| abstract_inverted_index.ligação | 351 |
| abstract_inverted_index.monitorar | 415, 425 |
| abstract_inverted_index.possível | 237, 337, 407 |
| abstract_inverted_index.protocolo | 158, 214, 315, 469, 497 |
| abstract_inverted_index.reações | 19 |
| abstract_inverted_index.solução | 250 |
| abstract_inverted_index.técnicas | 108, 146, 321 |
| abstract_inverted_index.utilizada | 73, 83, 132 |
| abstract_inverted_index.vantagens | 103 |
| abstract_inverted_index.Atualmente | 91 |
| abstract_inverted_index.Conclui-se | 464 |
| abstract_inverted_index.Curcumina. | 209 |
| abstract_inverted_index.absorção | 245 |
| abstract_inverted_index.ativação | 28 |
| abstract_inverted_index.comparadas | 105, 309 |
| abstract_inverted_index.demonstrar | 238 |
| abstract_inverted_index.diferentes | 355 |
| abstract_inverted_index.eficientes | 13 |
| abstract_inverted_index.formadoras | 305 |
| abstract_inverted_index.formação | 427, 461 |
| abstract_inverted_index.mobilidade | 365 |
| abstract_inverted_index.moléculas | 367, 387 |
| abstract_inverted_index.utiliza-se | 191 |
| abstract_inverted_index.aplicação | 160 |
| abstract_inverted_index.categorias: | 62 |
| abstract_inverted_index.compreender | 338 |
| abstract_inverted_index.condições | 372 |
| abstract_inverted_index.células.\n | 504 |
| abstract_inverted_index.demonstrado | 288 |
| abstract_inverted_index.eficiência | 142, 477 |
| abstract_inverted_index.específica | 40 |
| abstract_inverted_index.importantes | 115 |
| abstract_inverted_index.incubação | 444, 471 |
| abstract_inverted_index.infecções | 89 |
| abstract_inverted_index.interação | 201, 340 |
| abstract_inverted_index.microscopia | 323 |
| abstract_inverted_index.necessário | 447 |
| abstract_inverted_index.resistentes | 125 |
| abstract_inverted_index.tecnologias | 10 |
| abstract_inverted_index.tradicional | 316 |
| abstract_inverted_index.tratamentos | 75 |
| abstract_inverted_index.viabilidade | 280 |
| abstract_inverted_index.apresentaram | 295 |
| abstract_inverted_index.citotóxicas | 50 |
| abstract_inverted_index.comprimentos | 42 |
| abstract_inverted_index.determinando | 431 |
| abstract_inverted_index.diminuição | 296 |
| abstract_inverted_index.eficiência, | 167 |
| abstract_inverted_index.fotoproduto, | 430 |
| abstract_inverted_index.iluminação | 36, 376, 441, 473 |
| abstract_inverted_index.inativação | 67 |
| abstract_inverted_index.incubação. | 235 |
| abstract_inverted_index.interações | 174 |
| abstract_inverted_index.localizadas. | 90 |
| abstract_inverted_index.seletividade | 118, 479 |
| abstract_inverted_index.significante | 460 |
| abstract_inverted_index.sobrenadante | 247 |
| abstract_inverted_index.fotodinâmica | 64, 68 |
| abstract_inverted_index.fotoprodutos. | 463 |
| abstract_inverted_index.monitoramento | 182 |
| abstract_inverted_index.oncológicos, | 76 |
| abstract_inverted_index.possivelmente | 494 |
| abstract_inverted_index.preocupação | 4 |
| abstract_inverted_index.tradicionais. | 147 |
| abstract_inverted_index.fluorescência | 326, 335, 411 |
| abstract_inverted_index.fotodinâmicas | 20 |
| abstract_inverted_index.fotossensível | 32 |
| abstract_inverted_index.internalizado, | 458 |
| abstract_inverted_index.internalizaram | 261 |
| abstract_inverted_index.característicos | 392, 402 |
| abstract_inverted_index.dermatológicos, | 77 |
| abstract_inverted_index.internalização | 220 |
| abstract_inverted_index.micro-organismos | 87, 124 |
| abstract_inverted_index.Photogem&reg; | 207, 286, 413 |
| abstract_inverted_index.descontaminação | 85, 110 |
| abstract_inverted_index.pré-iluminação | 227, 260, 294 |
| abstract_inverted_index.Photogem&reg;, | 254 |
| abstract_inverted_index.Photogem&reg;. | 404 |
| abstract_inverted_index.(fotossensibilizador | 33 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5066272158 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 1 |
| citation_normalized_percentile |