Aurora A Kinase Inhibition Is Synthetic Lethal With the Activation of MYCN in Retinoblastoma Article Swipe
Related Concepts
Retinoblastoma
Kinase
Cancer research
Medicine
Chemistry
Cell biology
Biology
Biochemistry
Gene
Qi-Li Liao
,
Jie Yang
,
Hanhan Shi
,
Reyizha Mengjiang
,
Yongyun Li
,
Qianqian Zhang
,
Xuyang Wen
,
Shengfang Ge
,
Peiwei Chai
,
Xianqun Fan
,
Renbing Jia
,
Jiayan Fan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1167/iovs.66.2.20
· OA: W4407240758
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1167/iovs.66.2.20
· OA: W4407240758
Collectively, these findings demonstrate that AURKA is crucial for RB progression and further expanded the current understanding of synthetic lethal therapeutic strategies. Our study indicates that AURKA inhibitors may represent a new therapeutic strategy for selectively targeting patients with RB with RB1-deficient and MYCN-amplification to improve the prognosis of aggressive types of patients with RB.
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