Author response: BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health Article Swipe
Dianyuan Zhao
,
Ziwei Huang
,
Xiaoyu Li
,
Huan Wang
,
Qingwei Hou
,
Yuyao Wang
,
Fang Yan
,
Wenting Yang
,
Di Liu
,
Shaoqiong Yi
,
Chunguang Han
,
Yanan Hao
,
Li Tang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7554/elife.95811.1.sa3
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7554/elife.95811.1.sa3
The liver is the largest solid organ in the body and is primarily composed of HCs, ECs, KCs, and HSCs, which spatially interact and cooperate with each other to maintain liver homeostasis. However, the complexity and molecular mechanisms underlying the crosstalk between these different cell types remain to be revealed. Here, we generated mice with conditional deletion of Bmp9/10 in different liver cell types and demonstrated that HSCs were the major source of BMP9 and BMP10 in the liver. Using transgenic ALK1 (receptor for BMP9/10) reporter mice, we found that ALK1 is expressed on KCs and ECs other than HCs and HSCs. KCs from Bmp9/10HSC-KO (conditional deletion of Bmp9/10 from HSCs) mice lost their signature gene expression, such as ID1/3, CLEC4F, VSIG4 and CLEC2, and were replaced by monocyte-derived macrophages. ECs from Bmp9/10HSC-KO mice also lost their identity and were transdifferentiated into continuous ECs, ultimately leading to collagen IV deposition and liver fibrosis. Hepatic ECs express several angiocrine factors, such as BMP2, BMP6, Wnt2 and Rspo3, to regulate liver iron metabolism and metabolic zonation. We found that these angiocrine factors were significantly decreased in ECs from Bmp9/10HSC-KO mice, which further resulted in liver iron overload and disruption of HC zonation. In summary, we demonstrated that HSCs play a central role in mediating liver cell‒cell crosstalk via the production of BMP9/10 to maintain liver health.
Related Topics
Metadata
- Type
- peer-review
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.95811.1.sa3
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4394734797Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.95811.1.sa3Digital Object Identifier
- Title
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Author response: BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver healthWork title
- Type
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peer-reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-12Full publication date if available
- Authors
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Dianyuan Zhao, Ziwei Huang, Xiaoyu Li, Huan Wang, Qingwei Hou, Yuyao Wang, Fang Yan, Wenting Yang, Di Liu, Shaoqiong Yi, Chunguang Han, Yanan Hao, Li TangList of authors in order
- Landing page
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https://doi.org/10.7554/elife.95811.1.sa3Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7554/elife.95811.1.sa3Direct OA link when available
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Crosstalk, Chemistry, Cell biology, Biology, Engineering, Electronic engineeringTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| related_works | https://openalex.org/W4387497383, https://openalex.org/W2948807893, https://openalex.org/W2778153218, https://openalex.org/W2748952813, https://openalex.org/W1531601525, https://openalex.org/W4391375266, https://openalex.org/W2078814861, https://openalex.org/W2527526854, https://openalex.org/W1976181487, https://openalex.org/W1986764834 |
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| publication_date | 2024-04-12 |
| publication_year | 2024 |
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