Author Response: Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology Article Swipe
Won Yeong Park
,
Jieun Yun
,
Jinho Shin
,
Byung Ho Oh
,
Gilsuk Yoon
,
Seung‐Mo Hong
,
Ki Hean Kim
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7554/elife.92614.2.sa3
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7554/elife.92614.2.sa3
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained slide-based pathology by providing cellular information in high throughput manner. However, conventional techniques provided superficial information only due to shallow imaging depths. Herein, we developed open-top two-photon light sheet microscopy (OT-TP-LSM) for intraoperative 3D pathology. An extended depth of field two-photon excitation light sheet was generated by scanning a nondiffractive Bessel beam, and selective planar imaging was conducted with cameras at 400 frames/s max during the lateral translation of tissue specimens. Intrinsic second harmonic generation was collected for additional extracellular matrix (ECM) visualization. OT-TP-LSM was tested in various human cancer specimens including skin, pancreas, and prostate. High imaging depths were achieved owing to long excitation wavelengths and long wavelength fluorophores. 3D visualization of both cells and ECM enhanced the ability of cancer detection. Furthermore, an unsupervised deep learning network was employed for the style transfer of OT-TP-LSM images to virtual H&E images. The virtual H&E images exhibited comparable histological characteristics to real ones. OT-TP-LSM may have the potential for histopathological examination in surgical and biopsy applications by rapidly providing 3D information.
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Metadata
- Type
- peer-review
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.92614.2.sa3
- OA Status
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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- DOI
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https://doi.org/10.7554/elife.92614.2.sa3Digital Object Identifier
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Author Response: Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathologyWork title
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peer-reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-02-28Full publication date if available
- Authors
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Won Yeong Park, Jieun Yun, Jinho Shin, Byung Ho Oh, Gilsuk Yoon, Seung‐Mo Hong, Ki Hean KimList of authors in order
- Landing page
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https://doi.org/10.7554/elife.92614.2.sa3Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7554/elife.92614.2.sa3Direct OA link when available
- Concepts
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Microscopy, Two-photon excitation microscopy, Materials science, H&E stain, Pathology, Optics, Biomedical engineering, Bessel beam, Medicine, Beam (structure), Staining, Physics, FluorescenceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.we | 44 |
| abstract_inverted_index.400 | 82 |
| abstract_inverted_index.ECM | 137 |
| abstract_inverted_index.H&E | 161, 165 |
| abstract_inverted_index.The | 163 |
| abstract_inverted_index.and | 17, 73, 115, 127, 136, 184 |
| abstract_inverted_index.due | 38 |
| abstract_inverted_index.for | 52, 98, 152, 179 |
| abstract_inverted_index.max | 84 |
| abstract_inverted_index.may | 175 |
| abstract_inverted_index.the | 86, 139, 153, 177 |
| abstract_inverted_index.was | 65, 77, 96, 105, 150 |
| abstract_inverted_index.(3D) | 5 |
| abstract_inverted_index.High | 117 |
| abstract_inverted_index.both | 134 |
| abstract_inverted_index.deep | 147 |
| abstract_inverted_index.have | 176 |
| abstract_inverted_index.high | 28 |
| abstract_inverted_index.long | 124, 128 |
| abstract_inverted_index.only | 37 |
| abstract_inverted_index.real | 172 |
| abstract_inverted_index.were | 120 |
| abstract_inverted_index.with | 79 |
| abstract_inverted_index.(ECM) | 102 |
| abstract_inverted_index.(H&E) | 19 |
| abstract_inverted_index.based | 2 |
| abstract_inverted_index.beam, | 72 |
| abstract_inverted_index.cells | 135 |
| abstract_inverted_index.depth | 58 |
| abstract_inverted_index.eosin | 18 |
| abstract_inverted_index.field | 60 |
| abstract_inverted_index.holds | 8 |
| abstract_inverted_index.human | 109 |
| abstract_inverted_index.light | 48, 63 |
| abstract_inverted_index.ones. | 173 |
| abstract_inverted_index.owing | 122 |
| abstract_inverted_index.sheet | 49, 64 |
| abstract_inverted_index.skin, | 113 |
| abstract_inverted_index.style | 154 |
| abstract_inverted_index.Bessel | 71 |
| abstract_inverted_index.biopsy | 185 |
| abstract_inverted_index.cancer | 110, 142 |
| abstract_inverted_index.depths | 119 |
| abstract_inverted_index.during | 85 |
| abstract_inverted_index.images | 158, 166 |
| abstract_inverted_index.matrix | 101 |
| abstract_inverted_index.planar | 75 |
| abstract_inverted_index.second | 93 |
| abstract_inverted_index.tested | 106 |
| abstract_inverted_index.tissue | 90 |
| abstract_inverted_index.Herein, | 43 |
| abstract_inverted_index.ability | 140 |
| abstract_inverted_index.cameras | 80 |
| abstract_inverted_index.depths. | 42 |
| abstract_inverted_index.images. | 162 |
| abstract_inverted_index.imaging | 41, 76, 118 |
| abstract_inverted_index.lateral | 87 |
| abstract_inverted_index.manner. | 30 |
| abstract_inverted_index.network | 149 |
| abstract_inverted_index.optical | 6 |
| abstract_inverted_index.promise | 9 |
| abstract_inverted_index.rapidly | 188 |
| abstract_inverted_index.shallow | 40 |
| abstract_inverted_index.stained | 20 |
| abstract_inverted_index.various | 108 |
| abstract_inverted_index.virtual | 160, 164 |
| abstract_inverted_index.However, | 31 |
| abstract_inverted_index.achieved | 121 |
| abstract_inverted_index.cellular | 25 |
| abstract_inverted_index.employed | 151 |
| abstract_inverted_index.enhanced | 138 |
| abstract_inverted_index.extended | 57 |
| abstract_inverted_index.frames/s | 83 |
| abstract_inverted_index.harmonic | 94 |
| abstract_inverted_index.learning | 148 |
| abstract_inverted_index.open-top | 46 |
| abstract_inverted_index.provided | 34 |
| abstract_inverted_index.scanning | 68 |
| abstract_inverted_index.surgical | 183 |
| abstract_inverted_index.transfer | 155 |
| abstract_inverted_index.Intrinsic | 92 |
| abstract_inverted_index.OT-TP-LSM | 104, 157, 174 |
| abstract_inverted_index.collected | 97 |
| abstract_inverted_index.conducted | 78 |
| abstract_inverted_index.developed | 45 |
| abstract_inverted_index.exhibited | 167 |
| abstract_inverted_index.generated | 66 |
| abstract_inverted_index.including | 112 |
| abstract_inverted_index.pancreas, | 114 |
| abstract_inverted_index.pathology | 1, 22 |
| abstract_inverted_index.potential | 178 |
| abstract_inverted_index.prostate. | 116 |
| abstract_inverted_index.providing | 24, 189 |
| abstract_inverted_index.selective | 74 |
| abstract_inverted_index.specimens | 111 |
| abstract_inverted_index.additional | 99 |
| abstract_inverted_index.comparable | 168 |
| abstract_inverted_index.complement | 12 |
| abstract_inverted_index.detection. | 143 |
| abstract_inverted_index.excitation | 62, 125 |
| abstract_inverted_index.generation | 95 |
| abstract_inverted_index.microscopy | 7, 50 |
| abstract_inverted_index.pathology. | 55 |
| abstract_inverted_index.specimens. | 91 |
| abstract_inverted_index.techniques | 33 |
| abstract_inverted_index.throughput | 29 |
| abstract_inverted_index.two-photon | 47, 61 |
| abstract_inverted_index.wavelength | 129 |
| abstract_inverted_index.(OT-TP-LSM) | 51 |
| abstract_inverted_index.destructive | 15 |
| abstract_inverted_index.examination | 181 |
| abstract_inverted_index.hematoxylin | 16 |
| abstract_inverted_index.information | 26, 36 |
| abstract_inverted_index.slide-based | 21 |
| abstract_inverted_index.superficial | 35 |
| abstract_inverted_index.traditional | 14 |
| abstract_inverted_index.translation | 88 |
| abstract_inverted_index.wavelengths | 126 |
| abstract_inverted_index.Furthermore, | 144 |
| abstract_inverted_index.applications | 186 |
| abstract_inverted_index.conventional | 32 |
| abstract_inverted_index.histological | 169 |
| abstract_inverted_index.information. | 191 |
| abstract_inverted_index.unsupervised | 146 |
| abstract_inverted_index.extracellular | 100 |
| abstract_inverted_index.fluorophores. | 130 |
| abstract_inverted_index.visualization | 132 |
| abstract_inverted_index.Nondestructive | 0 |
| abstract_inverted_index.intraoperative | 53 |
| abstract_inverted_index.nondiffractive | 70 |
| abstract_inverted_index.visualization. | 103 |
| abstract_inverted_index.characteristics | 170 |
| abstract_inverted_index.histopathological | 180 |
| abstract_inverted_index.three-dimensional | 4 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile |