Autologous Neural Stem Cell Encapsulation in CT04-Integrated Fibrin Hydrogel Enhances Tissue Regeneration After Spinal Cord Injury in Monkeys Article Swipe
Razieh Jaberi
,
Prince David Okoro
,
Mostafa HajiNasrollah
,
Masoumeh Zarei Khairabady
,
Sara Mirsadeghi
,
Saeid Rahmani
,
Zahra Nazemi
,
Iman Noshadi
,
Firas Kobeissy
,
Sahar Kiani
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7871658/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7871658/v1
Spinal cord injury (SCI) is a major traumatic insult that leads to significant motor and sensory impairments. Following SCI, an inhibitory microenvironment develops, accompanied by substantial neuronal loss. A single therapeutic approach may not achieve substantial functional recovery. Therefore, strategies aimed at addressing the inhibitory environment and enhancing cellular engraftment are crucial for optimal recovery. In this study, we investigated the efficacy of combining an injectable fibrin hydrogel with subventricular zone-derived neural stem cells (SVZ-NSCs) and CT04, a RhoA inhibitor, in a rhesus monkey model of SCI. After characterizing SVZ-NSCs and optimizing the CT04 dosage, we administered the combination therapy during the sub-acute phase of SCI. Our results indicated that this combination treatment significantly improved neuronal differentiation and integration of grafted NSCs and promoted axonal regeneration. Compared to cell transplantation or CT04 treatment alone, animals receiving the combination therapy exhibited superior functional recovery. These findings highlight a promising approach for treating SCI by combining therapies to enhance NSC transplantation and axonal repair using an advanced injectable hydrogel.
Related Topics
Concepts
Spinal cord injury
Neural stem cell
Transplantation
Medicine
Fibrin
Cell therapy
Spinal cord
Neuroscience
Regenerative medicine
Regeneration (biology)
Subventricular zone
Inhibitory postsynaptic potential
Stem cell
Pharmacology
Stem-cell therapy
Cell
Cancer research
Ischemic injury
Combination therapy
Therapeutic approach
Neural cell
Central nervous system
Neuroprotection
Cord
Microglia
Chemistry
Metadata
- Type
- article
- Landing Page
- https://doi.org/10.21203/rs.3.rs-7871658/v1
- OA Status
- gold
- References
- 86
- OpenAlex ID
- https://openalex.org/W7105858165
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7105858165Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-7871658/v1Digital Object Identifier
- Title
-
Autologous Neural Stem Cell Encapsulation in CT04-Integrated Fibrin Hydrogel Enhances Tissue Regeneration After Spinal Cord Injury in MonkeysWork title
- Type
-
articleOpenAlex work type
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-17Full publication date if available
- Authors
-
Razieh Jaberi, Prince David Okoro, Mostafa HajiNasrollah, Masoumeh Zarei Khairabady, Sara Mirsadeghi, Saeid Rahmani, Zahra Nazemi, Iman Noshadi, Firas Kobeissy, Sahar KianiList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-7871658/v1Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.21203/rs.3.rs-7871658/v1Direct OA link when available
- Concepts
-
Spinal cord injury, Neural stem cell, Transplantation, Medicine, Fibrin, Cell therapy, Spinal cord, Neuroscience, Regenerative medicine, Regeneration (biology), Subventricular zone, Inhibitory postsynaptic potential, Stem cell, Pharmacology, Stem-cell therapy, Cell, Cancer research, Ischemic injury, Combination therapy, Therapeutic approach, Neural cell, Central nervous system, Neuroprotection, Cord, Microglia, ChemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
86Number of works referenced by this work
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