AutophagosOMES: identification of autophagosomal cargo in CD4+ T cells by proteomics Article Swipe
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· 2022
· Open Access
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· DOI: https://doi.org/10.1080/15548627.2022.2161154
· OA: W4313277424
Macroautophagy/autophagy, a cellular process that sequesters and breaks down cellular components in the lysosome/vacuole, is important in various events where cell composition undergoes changes. Broadly, autophagy is involved in T cell regulation including maintaining cell homeostasis. One process where a cell alters its composition is in the activation of helper T cells in the immune system. When helper (CD4<sup>+</sup>) T cells are activated by antigens, they both grow and alter their cellular components to become effector T cells. Autophagy is the process that facilitates the breakdown of these cellular components and is therefore hypothesized to have a role in CD4<sup>+</sup> T cell activation. Previous research has concluded that CD4<sup>+</sup> T cell activation induces autophagy, providing an avenue for further research aimed at examining the ways in which this induced autophagy affects CD4<sup>+</sup> T cell proliferation and function. Toward this end, Zhou et al. researched the autophagosomal cargo present within CD4<sup>+</sup> T cells and the impact this cargo has on CD4<sup>+</sup> T cell proliferation.
