Avaliação histopatológica, hematológica e bioquímica dos efeitos da ozonioterapia na inflamação induzida por carragenina no músculo gastrocnêmio de ratos wistar Article Swipe

View

Gabriela Aparecida Machado Tremador , Maria Auxiliadora de Souza Mendes Gomes , Maria Fátima das Graças Fernandes da Silva , Orivaldo Pereira Ramos , Maria Júlia De Oliveira Santos Gualberto , Silvia Zucchi Bailão , José Roberto Cunha , Ana Rosa Crisci ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.34117/bjdv10n12-008

A Ozonioterapia tem sido objeto de estudo multidisciplinar por suas propriedades microbicidas, anti-inflamatórias e terapêuticas que podem ser aplicadas na área da saúde, permitindo ser administrada por diversas vias, tanto com o uso isolado do insumo ou como coadjuvante a outros tratamentos. Sendo um gás natural, não apresenta relatos de efeitos adversos, sendo uma opção viável quando comparado a medicamentos normalmente utilizados. Esse trabalho visou analisar os efeitos da ozonioterapia no processo inflamatório do músculo gastrocnêmio, induzido pela Carragenina, por meio da avaliação das enzimas TGO, TGP, ureia e creatinina e a velocidade de hemossedimentação (VHS) e da analise histopatologia do músculo e dos tecidos subjacentes. Foram analisados um total 32 ratos da espécie Rattus novergicus de linhagem Wistar, fêmeas, pesando em média 300g, que foram divididos em quatro grupos, grupo 1: tratamento com salina (controle negativo); grupo 2: ozônio intramuscular; grupo 3: tratamento medicamentoso com celecoxibe por gavagem (controle positivo) e grupo 4: gavagem de celecoxibe + ozônio intramuscular, para realizar a comparação. Os resultados do VHS embora não foram estatisticamente significativos (P=0,5) os grupos tratados foram bem menores comparados com o grupo controle, indicando uma menor inflamação. As dosagens enzimáticas demonstraram prejuízos hepáticos e renais em todos os tratamentos. Na histopatologia, as fibras musculares e tecido conjuntivo adjacente apresentaram-se mais preservados no grupo tratado com celebra e ozônio. Concluiu-se que a ozonioterapia foi promissora em alguns parâmetros enquanto em outros apontou a necessidade de mais estudos, tendo um melhor aproveitamento quando utilizada como um tratamento coadjuvante.

Related Topics

Concepts

Medicine Molecular biology Chemistry Biology

Metadata

Type: article
Language: pt
Landing Page: https://doi.org/10.34117/bjdv10n12-008
OA Status: diamond
Related Works: 10
OpenAlex ID: https://openalex.org/W4405032244

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4405032244

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.34117/bjdv10n12-008

Digital Object Identifier
Title: Avaliação histopatológica, hematológica e bioquímica dos efeitos da ozonioterapia na inflamação induzida por carragenina no músculo gastrocnêmio de ratos wistar

Work title
Type: article

OpenAlex work type
Language: pt

Primary language
Publication year: 2024

Year of publication
Publication date: 2024-12-04

Full publication date if available
Authors: Gabriela Aparecida Machado Tremador, Maria Auxiliadora de Souza Mendes Gomes, Maria Fátima das Graças Fernandes da Silva, Orivaldo Pereira Ramos, Maria Júlia De Oliveira Santos Gualberto, Silvia Zucchi Bailão, José Roberto Cunha, Ana Rosa Crisci

List of authors in order
Landing page: https://doi.org/10.34117/bjdv10n12-008

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: diamond

Open access status per OpenAlex
OA URL: https://doi.org/10.34117/bjdv10n12-008

Direct OA link when available
Concepts: Medicine, Molecular biology, Chemistry, Biology

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4405032244
doi	https://doi.org/10.34117/bjdv10n12-008
ids.doi	https://doi.org/10.34117/bjdv10n12-008
ids.openalex	https://openalex.org/W4405032244
fwci	0.0
type	article
title	Avaliação histopatológica, hematológica e bioquímica dos efeitos da ozonioterapia na inflamação induzida por carragenina no músculo gastrocnêmio de ratos wistar
biblio.issue	12
biblio.volume	10
biblio.last_page	e75508
biblio.first_page	e75508
topics[0].id	https://openalex.org/T13365
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9998999834060669
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2736
topics[0].subfield.display_name	Pharmacology
topics[0].display_name	Medical and Biological Ozone Research
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C71924100
concepts[0].level	0
concepts[0].score	0.48594534397125244
concepts[0].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[0].display_name	Medicine
concepts[1].id	https://openalex.org/C153911025
concepts[1].level	1
concepts[1].score	0.4468756318092346
concepts[1].wikidata	https://www.wikidata.org/wiki/Q7202
concepts[1].display_name	Molecular biology
concepts[2].id	https://openalex.org/C185592680
concepts[2].level	0
concepts[2].score	0.33725446462631226
concepts[2].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[2].display_name	Chemistry
concepts[3].id	https://openalex.org/C86803240
concepts[3].level	0
concepts[3].score	0.16345170140266418
concepts[3].wikidata	https://www.wikidata.org/wiki/Q420
concepts[3].display_name	Biology
keywords[0].id	https://openalex.org/keywords/medicine
keywords[0].score	0.48594534397125244
keywords[0].display_name	Medicine
keywords[1].id	https://openalex.org/keywords/molecular-biology
keywords[1].score	0.4468756318092346
keywords[1].display_name	Molecular biology
keywords[2].id	https://openalex.org/keywords/chemistry
keywords[2].score	0.33725446462631226
keywords[2].display_name	Chemistry
keywords[3].id	https://openalex.org/keywords/biology
keywords[3].score	0.16345170140266418
keywords[3].display_name	Biology
language	pt
locations[0].id	doi:10.34117/bjdv10n12-008
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4210234566
locations[0].source.issn	2525-8761
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	2525-8761
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	Brazilian Journal of Development
locations[0].source.host_organization	https://openalex.org/P4310312106
locations[0].source.host_organization_name	Brazilian Journal of Development
locations[0].source.host_organization_lineage	https://openalex.org/P4310312106
locations[0].license
locations[0].pdf_url
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Brazilian Journal of Development
locations[0].landing_page_url	https://doi.org/10.34117/bjdv10n12-008
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5115003187
authorships[0].author.orcid
authorships[0].author.display_name	Gabriela Aparecida Machado Tremador
authorships[0].author_position	first
authorships[0].raw_author_name	Gabriela Aparecida Machado Tremador
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5090919225
authorships[1].author.orcid	https://orcid.org/0000-0001-5908-1763
authorships[1].author.display_name	Maria Auxiliadora de Souza Mendes Gomes
authorships[1].author_position	middle
authorships[1].raw_author_name	Maria Julia de Matos Gomes
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5017179380
authorships[2].author.orcid	https://orcid.org/0000-0002-7081-817X
authorships[2].author.display_name	Maria Fátima das Graças Fernandes da Silva
authorships[2].author_position	middle
authorships[2].raw_author_name	Mayla Koglim da Silva
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5008185172
authorships[3].author.orcid
authorships[3].author.display_name	Orivaldo Pereira Ramos
authorships[3].author_position	middle
authorships[3].raw_author_name	Orivaldo Pereira Ramos
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5114314846
authorships[4].author.orcid
authorships[4].author.display_name	Maria Júlia De Oliveira Santos Gualberto
authorships[4].author_position	middle
authorships[4].raw_author_name	Maria Julia de Oliveira Santos Gualberto
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5115003188
authorships[5].author.orcid
authorships[5].author.display_name	Silvia Zucchi Bailão
authorships[5].author_position	middle
authorships[5].raw_author_name	Silvia Zucchi Bailão
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5109762960
authorships[6].author.orcid
authorships[6].author.display_name	José Roberto Cunha
authorships[6].author_position	middle
authorships[6].raw_author_name	José Roberto Cunha Junior
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5103134210
authorships[7].author.orcid	https://orcid.org/0000-0001-9876-4209
authorships[7].author.display_name	Ana Rosa Crisci
authorships[7].author_position	last
authorships[7].raw_author_name	Ana Rosa Crisci
authorships[7].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.34117/bjdv10n12-008
open_access.oa_status	diamond
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Avaliação histopatológica, hematológica e bioquímica dos efeitos da ozonioterapia na inflamação induzida por carragenina no músculo gastrocnêmio de ratos wistar
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T13365
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9998999834060669
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2736
primary_topic.subfield.display_name	Pharmacology
primary_topic.display_name	Medical and Biological Ozone Research
related_works	https://openalex.org/W4387497383, https://openalex.org/W2948807893, https://openalex.org/W2899084033, https://openalex.org/W2778153218, https://openalex.org/W2748952813, https://openalex.org/W1531601525, https://openalex.org/W4391375266, https://openalex.org/W3031052312, https://openalex.org/W4389568370, https://openalex.org/W3032375762
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.34117/bjdv10n12-008
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4210234566
best_oa_location.source.issn	2525-8761
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	2525-8761
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	Brazilian Journal of Development
best_oa_location.source.host_organization	https://openalex.org/P4310312106
best_oa_location.source.host_organization_name	Brazilian Journal of Development
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310312106
best_oa_location.license
best_oa_location.pdf_url
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Brazilian Journal of Development
best_oa_location.landing_page_url	https://doi.org/10.34117/bjdv10n12-008
primary_location.id	doi:10.34117/bjdv10n12-008
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4210234566
primary_location.source.issn	2525-8761
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	2525-8761
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	Brazilian Journal of Development
primary_location.source.host_organization	https://openalex.org/P4310312106
primary_location.source.host_organization_name	Brazilian Journal of Development
primary_location.source.host_organization_lineage	https://openalex.org/P4310312106
primary_location.license
primary_location.pdf_url
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Brazilian Journal of Development
primary_location.landing_page_url	https://doi.org/10.34117/bjdv10n12-008
publication_date	2024-12-04
publication_year	2024
referenced_works_count	0
abstract_inverted_index.+	157
abstract_inverted_index.A	0
abstract_inverted_index.a	39, 58, 91, 162, 222, 233
abstract_inverted_index.e	13, 88, 90, 96, 102, 151, 195, 206, 218
abstract_inverted_index.o	31, 182
abstract_inverted_index.1:	131
abstract_inverted_index.2:	138
abstract_inverted_index.32	110
abstract_inverted_index.3:	142
abstract_inverted_index.4:	153
abstract_inverted_index.As	189
abstract_inverted_index.Na	201
abstract_inverted_index.Os	164
abstract_inverted_index.as	203
abstract_inverted_index.da	21, 68, 81, 97, 112
abstract_inverted_index.de	5, 49, 93, 116, 155, 235
abstract_inverted_index.do	34, 73, 100, 166
abstract_inverted_index.em	121, 127, 197, 226, 230
abstract_inverted_index.na	19
abstract_inverted_index.no	70, 213
abstract_inverted_index.os	66, 174, 199
abstract_inverted_index.ou	36
abstract_inverted_index.um	43, 108, 239, 245
abstract_inverted_index.VHS	167
abstract_inverted_index.bem	178
abstract_inverted_index.com	30, 133, 145, 181, 216
abstract_inverted_index.das	83
abstract_inverted_index.dos	103
abstract_inverted_index.foi	224
abstract_inverted_index.por	8, 26, 79, 147
abstract_inverted_index.que	15, 124, 221
abstract_inverted_index.ser	17, 24
abstract_inverted_index.tem	2
abstract_inverted_index.uma	53, 186
abstract_inverted_index.uso	32
abstract_inverted_index.Esse	62
abstract_inverted_index.TGO,	85
abstract_inverted_index.TGP,	86
abstract_inverted_index.como	37, 244
abstract_inverted_index.gás	44
abstract_inverted_index.mais	211, 236
abstract_inverted_index.meio	80
abstract_inverted_index.não	46, 169
abstract_inverted_index.para	160
abstract_inverted_index.pela	77
abstract_inverted_index.sido	3
abstract_inverted_index.suas	9
abstract_inverted_index.(VHS)	95
abstract_inverted_index.300g,	123
abstract_inverted_index.Foram	106
abstract_inverted_index.Sendo	42
abstract_inverted_index.foram	125, 170, 177
abstract_inverted_index.grupo	130, 137, 141, 152, 183, 214
abstract_inverted_index.menor	187
abstract_inverted_index.podem	16
abstract_inverted_index.ratos	111
abstract_inverted_index.sendo	52
abstract_inverted_index.tanto	29
abstract_inverted_index.tendo	238
abstract_inverted_index.todos	198
abstract_inverted_index.total	109
abstract_inverted_index.ureia	87
abstract_inverted_index.vias,	28
abstract_inverted_index.visou	64
abstract_inverted_index.área	20
abstract_inverted_index.Rattus	114
abstract_inverted_index.alguns	227
abstract_inverted_index.embora	168
abstract_inverted_index.estudo	6
abstract_inverted_index.fibras	204
abstract_inverted_index.grupos	175
abstract_inverted_index.insumo	35
abstract_inverted_index.melhor	240
abstract_inverted_index.média	122
abstract_inverted_index.objeto	4
abstract_inverted_index.outros	40, 231
abstract_inverted_index.quando	56, 242
abstract_inverted_index.quatro	128
abstract_inverted_index.renais	196
abstract_inverted_index.salina	134
abstract_inverted_index.tecido	207
abstract_inverted_index.(P=0,5)	173
abstract_inverted_index.Wistar,	118
abstract_inverted_index.analise	98
abstract_inverted_index.apontou	232
abstract_inverted_index.celebra	217
abstract_inverted_index.efeitos	50, 67
abstract_inverted_index.enzimas	84
abstract_inverted_index.gavagem	148, 154
abstract_inverted_index.grupos,	129
abstract_inverted_index.isolado	33
abstract_inverted_index.menores	179
abstract_inverted_index.opção	54
abstract_inverted_index.ozônio	139, 158
abstract_inverted_index.pesando	120
abstract_inverted_index.relatos	48
abstract_inverted_index.saúde,	22
abstract_inverted_index.tecidos	104
abstract_inverted_index.tratado	215
abstract_inverted_index.viável	55
abstract_inverted_index.analisar	65
abstract_inverted_index.diversas	27
abstract_inverted_index.dosagens	190
abstract_inverted_index.enquanto	229
abstract_inverted_index.espécie	113
abstract_inverted_index.estudos,	237
abstract_inverted_index.fêmeas,	119
abstract_inverted_index.induzido	76
abstract_inverted_index.linhagem	117
abstract_inverted_index.músculo	74, 101
abstract_inverted_index.natural,	45
abstract_inverted_index.ozônio.	219
abstract_inverted_index.processo	71
abstract_inverted_index.realizar	161
abstract_inverted_index.trabalho	63
abstract_inverted_index.tratados	176
abstract_inverted_index.(controle	135, 149
abstract_inverted_index.adjacente	209
abstract_inverted_index.adversos,	51
abstract_inverted_index.aplicadas	18
abstract_inverted_index.apresenta	47
abstract_inverted_index.comparado	57
abstract_inverted_index.controle,	184
abstract_inverted_index.divididos	126
abstract_inverted_index.indicando	185
abstract_inverted_index.positivo)	150
abstract_inverted_index.utilizada	243
abstract_inverted_index.analisados	107
abstract_inverted_index.celecoxibe	146, 156
abstract_inverted_index.comparados	180
abstract_inverted_index.conjuntivo	208
abstract_inverted_index.creatinina	89
abstract_inverted_index.hepáticos	194
abstract_inverted_index.musculares	205
abstract_inverted_index.negativo);	136
abstract_inverted_index.novergicus	115
abstract_inverted_index.permitindo	23
abstract_inverted_index.prejuízos	193
abstract_inverted_index.promissora	225
abstract_inverted_index.resultados	165
abstract_inverted_index.tratamento	132, 143, 246
abstract_inverted_index.velocidade	92
abstract_inverted_index.Concluiu-se	220
abstract_inverted_index.avaliação	82
abstract_inverted_index.coadjuvante	38
abstract_inverted_index.necessidade	234
abstract_inverted_index.normalmente	60
abstract_inverted_index.parâmetros	228
abstract_inverted_index.preservados	212
abstract_inverted_index.utilizados.	61
abstract_inverted_index.Carragenina,	78
abstract_inverted_index.administrada	25
abstract_inverted_index.coadjuvante.	247
abstract_inverted_index.demonstraram	192
abstract_inverted_index.enzimáticas	191
abstract_inverted_index.medicamentos	59
abstract_inverted_index.propriedades	10
abstract_inverted_index.subjacentes.	105
abstract_inverted_index.tratamentos.	41, 200
abstract_inverted_index.Ozonioterapia	1
abstract_inverted_index.comparação.	163
abstract_inverted_index.inflamatório	72
abstract_inverted_index.inflamação.	188
abstract_inverted_index.medicamentoso	144
abstract_inverted_index.microbicidas,	11
abstract_inverted_index.ozonioterapia	69, 223
abstract_inverted_index.terapêuticas	14
abstract_inverted_index.aproveitamento	241
abstract_inverted_index.gastrocnêmio,	75
abstract_inverted_index.histopatologia	99
abstract_inverted_index.intramuscular,	159
abstract_inverted_index.intramuscular;	140
abstract_inverted_index.significativos	172
abstract_inverted_index.apresentaram-se	210
abstract_inverted_index.histopatologia,	202
abstract_inverted_index.estatisticamente	171
abstract_inverted_index.multidisciplinar	7
abstract_inverted_index.anti-inflamatórias	12
abstract_inverted_index.hemossedimentação	94
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	8
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.7400000095367432
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.25464933
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False