AYUSH-64 as an adjunct to Standard Care in mild to moderate COVID-19: An open-label randomized controlled trial in Chandigarh, India Article Swipe
Harbans Singh
,
Sumit Shrivastva
,
Babita Yadav
,
Amit Kumar
,
Sophia Jameela
,
Sanuj Muralidharan
,
Rijin Mohan
,
Shikha Chaudhary
,
Richa Singhal
,
Rakesh Rana
,
Shruti Khanduri
,
BS Sharma
,
Bhogavalli Chandrasekhararao
,
N. Srikanth
,
Sarika Chaturvedi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.31219/osf.io/xyuas
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.31219/osf.io/xyuas
Background: There is limited evidence on the safety and efficacy of administering Ayurveda interventions as add-on to the standard care for COVID-19. Objective: To explore the therapeutic efficacy and safety of AYUSH-64 as an add-on to standard care in the management of mild to moderate stage COVID-19.Design, setting, participants and interventions: This was an open-label randomized controlled trial with 80 patients of mild to moderate stage COVID-19. Participants in the AYUSH-64 add-on group received two tablets (500 mg each) three times daily for 30 days along with conventional standard care (Paracetamol, Cetirizine, Vitamin C, and Azithromycin). The control group received standard care alone. Main outcome measures: The primary outcome assessed was the proportion of participants with clinical recovery and negative RT-PCR assay for COVID-19 on day 7, 15, 23, and 30. Additionally, change in pro-inflammatory markers, metabolic functions, HRCT chest and incidence of Adverse Drug Reaction (ADR) / Serious Adverse Event (SAE) were assessed.Results: Statistically significant difference was observed in the proportion of participants with clinical recovery in the AYUSH-64 add-on group (p<0.001) at each of the scheduled follow-up visits. All the participants in the AYUSH-64 add-on group clinically recovered by day 23 compared to 32.4 per cent in the control group. The mean duration for clinical recovery in AYUSH-64 add-on group (5.8 ± 2.67 days) was less as compared to control group (10.0 ± 4.06 days). The proportion of participants who turned RT-PCR negative for COVID-19 on day 7, 15, and 23 were 81.8, 94.5, and 100 per cent in AYUSH-64 add-on group, and 79.4, 94.5, and 97.2 per cent in control group, however, the difference observed was statistically not significant (p=0.314). The proportion of participants with improvement in HRCT chest was statistically significant in AYUSH-64 add-on group (p=0.031) unlike in control group (p=0.210). Similar reductions in most inflammatory markers measured (IL-6, CRP, Serum ferritin, and LDH) on day 30 (p<0.05) were observed in both groups. Conclusion: AYUSH-64 as adjunct to standard conventional care is safe and hastens clinical recovery in adult patients with mild to moderate COVID-19.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.31219/osf.io/xyuas
- https://osf.io/xyuas/download
- OA Status
- gold
- Cited By
- 1
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4246815600
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4246815600Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.31219/osf.io/xyuasDigital Object Identifier
- Title
-
AYUSH-64 as an adjunct to Standard Care in mild to moderate COVID-19: An open-label randomized controlled trial in Chandigarh, IndiaWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-06Full publication date if available
- Authors
-
Harbans Singh, Sumit Shrivastva, Babita Yadav, Amit Kumar, Sophia Jameela, Sanuj Muralidharan, Rijin Mohan, Shikha Chaudhary, Richa Singhal, Rakesh Rana, Shruti Khanduri, BS Sharma, Bhogavalli Chandrasekhararao, N. Srikanth, Sarika ChaturvediList of authors in order
- Landing page
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https://doi.org/10.31219/osf.io/xyuasPublisher landing page
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https://osf.io/xyuas/downloadDirect link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://osf.io/xyuas/downloadDirect OA link when available
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Medicine, Randomized controlled trial, Adverse effect, Internal medicine, Clinical trial, Azithromycin, Incidence (geometry), Psychological intervention, Antibiotics, Nursing, Optics, Physics, Biology, MicrobiologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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