Azathioprine Hypersensitivity Syndrome Mimicking an Infection in a Systemic Lupus Erythematosus Patient: A Case Report Article Swipe

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Medicine Azathioprine Dermatology Systemic lupus Systemic lupus erythematosus Systemic disease Immunology Pathology Immunopathology Disease

Tania Paola Luján Chavarría , Carlos Esteban Giraldo , Natalia Andrea Uribe Ruíz , Carlos Múñiz , Adriana Lucía Vanegas-García ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.7759/cureus.86085 · OA: W4411320778

Azathioprine (AZA) is used in clinical practice as a steroid-sparing medication to treat diverse systemic autoimmune diseases, such as inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus. The adverse effects of AZA use include azathioprine hypersensitivity syndrome (AHS). AHS is a rare entity, but it can lead to fatal outcomes if not identified early. Fever and abdominal pain, while resembling other diseases, can be a sign of this disease. This paper discusses the case of a patient diagnosed with systemic lupus erythematosus who experienced AHS.