Azelastine–Fluticasone Combination Therapy in Allergic Rhinitis: Current Evidence and Clinical Implications in Children and Adults Article Swipe
Cristiana Indolfi
,
Angela Klain
,
Giulio Dinardo
,
Carolina Grella
,
Pierluigi Di Filippo
,
Ilaria Fatica
,
Vincenzo Napolano
,
Fabio Decimo
,
Michele Miraglia del Giudice
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ph18111624
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ph18111624
Allergic rhinitis (AR) is a common chronic respiratory disease that significantly impairs the life of children. While a combination intranasal spray of azelastine hydrochloride and fluticasone propionate (Aze-Flu) is an established effective treatment for adults with moderate-to-severe AR, the clinical evidence available in the pediatric population is limited. This review summarizes the current evidence on the efficacy, safety, and impact on Quality of Life (QoL) of Aze-Flu in children. Clinical trials have demonstrated that Aze-Flu provides faster and greater symptom relief in children with AR compared to fluticasone propionate (FP) monotherapy. One randomized controlled trial demonstrated that, although the overall change in the reflective Total Nasal Symptom Score (rTNSS) was not statistically different from the placebo, this was possibly due to rater assessment bias. Children’s symptoms self-assessment showed considerable ameliorations in both nasal and ocular scores. Furthermore, treatment with Aze-Flu has been shown to produce clinically relevant and statistically significant improvements in QoL compared to placebo in children with moderate-to-severe seasonal AR. The safety profile is favorable; a 3-month study confirmed that Aze-Flu is well-tolerated, with an incidence of treatment-related adverse events comparable to that of FP monotherapy. Beyond AR, emerging evidence suggests potential benefits of Aze-Flu in children with adenoid hypertrophy. The available evidence supports Aze-Flu as an effective and well-tolerated therapeutic option for children with moderate-to-severe AR, offering superior and faster symptom control than monotherapy and leading to meaningful improvements in quality of life. Future pediatric trials should incorporate validated, child-specific assessment tools to better capture treatment efficacy.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph18111624
- https://www.mdpi.com/1424-8247/18/11/1624/pdf?version=1761649255
- OA Status
- gold
- References
- 54
- OpenAlex ID
- https://openalex.org/W4415613986
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4415613986Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ph18111624Digital Object Identifier
- Title
-
Azelastine–Fluticasone Combination Therapy in Allergic Rhinitis: Current Evidence and Clinical Implications in Children and AdultsWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-10-28Full publication date if available
- Authors
-
Cristiana Indolfi, Angela Klain, Giulio Dinardo, Carolina Grella, Pierluigi Di Filippo, Ilaria Fatica, Vincenzo Napolano, Fabio Decimo, Michele Miraglia del GiudiceList of authors in order
- Landing page
-
https://doi.org/10.3390/ph18111624Publisher landing page
- PDF URL
-
https://www.mdpi.com/1424-8247/18/11/1624/pdf?version=1761649255Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1424-8247/18/11/1624/pdf?version=1761649255Direct OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
54Number of works referenced by this work
Full payload
| id | https://openalex.org/W4415613986 |
|---|---|
| doi | https://doi.org/10.3390/ph18111624 |
| ids.doi | https://doi.org/10.3390/ph18111624 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41304870 |
| ids.openalex | https://openalex.org/W4415613986 |
| fwci | 0.0 |
| type | review |
| title | Azelastine–Fluticasone Combination Therapy in Allergic Rhinitis: Current Evidence and Clinical Implications in Children and Adults |
| biblio.issue | 11 |
| biblio.volume | 18 |
| biblio.last_page | 1624 |
| biblio.first_page | 1624 |
| is_xpac | False |
| apc_list.value | 2000 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2165 |
| apc_paid.value | 2000 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2165 |
| language | en |
| locations[0].id | doi:10.3390/ph18111624 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S16322639 |
| locations[0].source.issn | 1424-8247 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1424-8247 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Pharmaceuticals |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1424-8247/18/11/1624/pdf?version=1761649255 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Pharmaceuticals |
| locations[0].landing_page_url | https://doi.org/10.3390/ph18111624 |
| locations[1].id | pmid:41304870 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Pharmaceuticals (Basel, Switzerland) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41304870 |
| locations[2].id | pmh:oai:doaj.org/article:ff42fc8f150b4bdcb0184a1b45d59665 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Pharmaceuticals, Vol 18, Iss 11, p 1624 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/ff42fc8f150b4bdcb0184a1b45d59665 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5044251268 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9513-193X |
| authorships[0].author.display_name | Cristiana Indolfi |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I197809005 |
| authorships[0].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Cristiana Indolfi |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[1].author.id | https://openalex.org/A5054704358 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-7823-2125 |
| authorships[1].author.display_name | Angela Klain |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I197809005 |
| authorships[1].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Angela Klain |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[2].author.id | https://openalex.org/A5076198034 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9952-1206 |
| authorships[2].author.display_name | Giulio Dinardo |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I197809005 |
| authorships[2].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Giulio Dinardo |
| authorships[2].is_corresponding | True |
| authorships[2].raw_affiliation_strings | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[3].author.id | https://openalex.org/A5098957859 |
| authorships[3].author.orcid | https://orcid.org/0009-0006-5029-7895 |
| authorships[3].author.display_name | Carolina Grella |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I197809005 |
| authorships[3].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Carolina Grella |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[4].author.id | https://openalex.org/A5118647217 |
| authorships[4].author.orcid | https://orcid.org/0009-0000-0810-4339 |
| authorships[4].author.display_name | Pierluigi Di Filippo |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I197809005 |
| authorships[4].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Pierluigi Di Filippo |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[5].author.id | https://openalex.org/A5120159498 |
| authorships[5].author.orcid | https://orcid.org/0009-0004-6105-4798 |
| authorships[5].author.display_name | Ilaria Fatica |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[5].institutions[0].id | https://openalex.org/I197809005 |
| authorships[5].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Ilaria Fatica |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[6].author.id | https://openalex.org/A5120159499 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Vincenzo Napolano |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[6].institutions[0].id | https://openalex.org/I197809005 |
| authorships[6].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Vincenzo Napolano |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[7].author.id | https://openalex.org/A5008720699 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Fabio Decimo |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[7].institutions[0].id | https://openalex.org/I197809005 |
| authorships[7].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Fabio Decimo |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[8].author.id | https://openalex.org/A5058515242 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-8369-5957 |
| authorships[8].author.display_name | Michele Miraglia del Giudice |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I197809005 |
| authorships[8].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Michele Miraglia del Giudice |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1424-8247/18/11/1624/pdf?version=1761649255 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-28T00:00:00 |
| display_name | Azelastine–Fluticasone Combination Therapy in Allergic Rhinitis: Current Evidence and Clinical Implications in Children and Adults |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic | |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.3390/ph18111624 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S16322639 |
| best_oa_location.source.issn | 1424-8247 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1424-8247 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Pharmaceuticals |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1424-8247/18/11/1624/pdf?version=1761649255 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Pharmaceuticals |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ph18111624 |
| primary_location.id | doi:10.3390/ph18111624 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S16322639 |
| primary_location.source.issn | 1424-8247 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1424-8247 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Pharmaceuticals |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1424-8247/18/11/1624/pdf?version=1761649255 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Pharmaceuticals |
| primary_location.landing_page_url | https://doi.org/10.3390/ph18111624 |
| publication_date | 2025-10-28 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2916610774, https://openalex.org/W4392702384, https://openalex.org/W2786694607, https://openalex.org/W3197501093, https://openalex.org/W3188315806, https://openalex.org/W4385812397, https://openalex.org/W2557939063, https://openalex.org/W2609470603, https://openalex.org/W4391772696, https://openalex.org/W2886179121, https://openalex.org/W2897292212, https://openalex.org/W2336306529, https://openalex.org/W2793440500, https://openalex.org/W2288721469, https://openalex.org/W3191482619, https://openalex.org/W2222847348, https://openalex.org/W4395702019, https://openalex.org/W4379390856, https://openalex.org/W4400595764, https://openalex.org/W1871694500, https://openalex.org/W4294275716, https://openalex.org/W4309748414, https://openalex.org/W2137163538, https://openalex.org/W4292075210, https://openalex.org/W4244631519, https://openalex.org/W3044735481, https://openalex.org/W2990570008, https://openalex.org/W2049540404, https://openalex.org/W1980065425, https://openalex.org/W2399611448, https://openalex.org/W2580531621, https://openalex.org/W3164596289, https://openalex.org/W4377990902, https://openalex.org/W4403338363, https://openalex.org/W4404822972, https://openalex.org/W4323569309, https://openalex.org/W4294295875, https://openalex.org/W4211003574, https://openalex.org/W4375866168, https://openalex.org/W1511865831, https://openalex.org/W2980595867, https://openalex.org/W2807821365, https://openalex.org/W2550048721, https://openalex.org/W4402807911, https://openalex.org/W4404444217, https://openalex.org/W4407608661, https://openalex.org/W1994606253, https://openalex.org/W2074936246, https://openalex.org/W4205252740, https://openalex.org/W4386332424, https://openalex.org/W4404938089, https://openalex.org/W2736143715, https://openalex.org/W3026067409, https://openalex.org/W4403527551 |
| referenced_works_count | 54 |
| abstract_inverted_index.a | 4, 17, 167 |
| abstract_inverted_index.AR | 84 |
| abstract_inverted_index.FP | 186 |
| abstract_inverted_index.an | 29, 176, 208 |
| abstract_inverted_index.as | 207 |
| abstract_inverted_index.in | 42, 67, 81, 101, 130, 151, 156, 197, 232 |
| abstract_inverted_index.is | 3, 28, 46, 165, 173 |
| abstract_inverted_index.of | 14, 21, 62, 65, 178, 185, 195, 234 |
| abstract_inverted_index.on | 54, 60 |
| abstract_inverted_index.to | 86, 120, 143, 154, 183, 229, 245 |
| abstract_inverted_index.AR, | 37, 189, 218 |
| abstract_inverted_index.AR. | 161 |
| abstract_inverted_index.One | 91 |
| abstract_inverted_index.QoL | 152 |
| abstract_inverted_index.The | 162, 202 |
| abstract_inverted_index.and | 24, 58, 77, 133, 147, 210, 221, 227 |
| abstract_inverted_index.due | 119 |
| abstract_inverted_index.for | 33, 214 |
| abstract_inverted_index.has | 140 |
| abstract_inverted_index.not | 110 |
| abstract_inverted_index.the | 12, 38, 43, 51, 55, 98, 102, 114 |
| abstract_inverted_index.was | 109, 117 |
| abstract_inverted_index.(AR) | 2 |
| abstract_inverted_index.(FP) | 89 |
| abstract_inverted_index.Life | 63 |
| abstract_inverted_index.This | 48 |
| abstract_inverted_index.been | 141 |
| abstract_inverted_index.both | 131 |
| abstract_inverted_index.from | 113 |
| abstract_inverted_index.have | 71 |
| abstract_inverted_index.life | 13 |
| abstract_inverted_index.than | 225 |
| abstract_inverted_index.that | 9, 73, 171, 184 |
| abstract_inverted_index.this | 116 |
| abstract_inverted_index.with | 35, 83, 138, 158, 175, 199, 216 |
| abstract_inverted_index.(QoL) | 64 |
| abstract_inverted_index.Nasal | 105 |
| abstract_inverted_index.Score | 107 |
| abstract_inverted_index.Total | 104 |
| abstract_inverted_index.While | 16 |
| abstract_inverted_index.bias. | 123 |
| abstract_inverted_index.life. | 235 |
| abstract_inverted_index.nasal | 132 |
| abstract_inverted_index.rater | 121 |
| abstract_inverted_index.shown | 142 |
| abstract_inverted_index.spray | 20 |
| abstract_inverted_index.study | 169 |
| abstract_inverted_index.that, | 96 |
| abstract_inverted_index.tools | 244 |
| abstract_inverted_index.trial | 94 |
| abstract_inverted_index.Beyond | 188 |
| abstract_inverted_index.Future | 236 |
| abstract_inverted_index.adults | 34 |
| abstract_inverted_index.better | 246 |
| abstract_inverted_index.change | 100 |
| abstract_inverted_index.common | 5 |
| abstract_inverted_index.events | 181 |
| abstract_inverted_index.faster | 76, 222 |
| abstract_inverted_index.impact | 59 |
| abstract_inverted_index.ocular | 134 |
| abstract_inverted_index.option | 213 |
| abstract_inverted_index.relief | 80 |
| abstract_inverted_index.review | 49 |
| abstract_inverted_index.safety | 163 |
| abstract_inverted_index.should | 239 |
| abstract_inverted_index.showed | 127 |
| abstract_inverted_index.trials | 70, 238 |
| abstract_inverted_index.(rTNSS) | 108 |
| abstract_inverted_index.3-month | 168 |
| abstract_inverted_index.Aze-Flu | 66, 74, 139, 172, 196, 206 |
| abstract_inverted_index.Quality | 61 |
| abstract_inverted_index.Symptom | 106 |
| abstract_inverted_index.adenoid | 200 |
| abstract_inverted_index.adverse | 180 |
| abstract_inverted_index.capture | 247 |
| abstract_inverted_index.chronic | 6 |
| abstract_inverted_index.control | 224 |
| abstract_inverted_index.current | 52 |
| abstract_inverted_index.disease | 8 |
| abstract_inverted_index.greater | 78 |
| abstract_inverted_index.impairs | 11 |
| abstract_inverted_index.leading | 228 |
| abstract_inverted_index.overall | 99 |
| abstract_inverted_index.placebo | 155 |
| abstract_inverted_index.produce | 144 |
| abstract_inverted_index.profile | 164 |
| abstract_inverted_index.quality | 233 |
| abstract_inverted_index.safety, | 57 |
| abstract_inverted_index.scores. | 135 |
| abstract_inverted_index.symptom | 79, 223 |
| abstract_inverted_index.Allergic | 0 |
| abstract_inverted_index.Clinical | 69 |
| abstract_inverted_index.although | 97 |
| abstract_inverted_index.benefits | 194 |
| abstract_inverted_index.children | 82, 157, 198, 215 |
| abstract_inverted_index.clinical | 39 |
| abstract_inverted_index.compared | 85, 153 |
| abstract_inverted_index.emerging | 190 |
| abstract_inverted_index.evidence | 40, 53, 191, 204 |
| abstract_inverted_index.limited. | 47 |
| abstract_inverted_index.offering | 219 |
| abstract_inverted_index.placebo, | 115 |
| abstract_inverted_index.possibly | 118 |
| abstract_inverted_index.provides | 75 |
| abstract_inverted_index.relevant | 146 |
| abstract_inverted_index.rhinitis | 1 |
| abstract_inverted_index.seasonal | 160 |
| abstract_inverted_index.suggests | 192 |
| abstract_inverted_index.superior | 220 |
| abstract_inverted_index.supports | 205 |
| abstract_inverted_index.symptoms | 125 |
| abstract_inverted_index.(Aze-Flu) | 27 |
| abstract_inverted_index.available | 41, 203 |
| abstract_inverted_index.children. | 15, 68 |
| abstract_inverted_index.confirmed | 170 |
| abstract_inverted_index.different | 112 |
| abstract_inverted_index.effective | 31, 209 |
| abstract_inverted_index.efficacy, | 56 |
| abstract_inverted_index.efficacy. | 249 |
| abstract_inverted_index.incidence | 177 |
| abstract_inverted_index.pediatric | 44, 237 |
| abstract_inverted_index.potential | 193 |
| abstract_inverted_index.treatment | 32, 137, 248 |
| abstract_inverted_index.assessment | 122, 243 |
| abstract_inverted_index.azelastine | 22 |
| abstract_inverted_index.clinically | 145 |
| abstract_inverted_index.comparable | 182 |
| abstract_inverted_index.controlled | 93 |
| abstract_inverted_index.favorable; | 166 |
| abstract_inverted_index.intranasal | 19 |
| abstract_inverted_index.meaningful | 230 |
| abstract_inverted_index.population | 45 |
| abstract_inverted_index.propionate | 26, 88 |
| abstract_inverted_index.randomized | 92 |
| abstract_inverted_index.reflective | 103 |
| abstract_inverted_index.summarizes | 50 |
| abstract_inverted_index.validated, | 241 |
| abstract_inverted_index.combination | 18 |
| abstract_inverted_index.established | 30 |
| abstract_inverted_index.fluticasone | 25, 87 |
| abstract_inverted_index.incorporate | 240 |
| abstract_inverted_index.monotherapy | 226 |
| abstract_inverted_index.respiratory | 7 |
| abstract_inverted_index.significant | 149 |
| abstract_inverted_index.therapeutic | 212 |
| abstract_inverted_index.Children’s | 124 |
| abstract_inverted_index.Furthermore, | 136 |
| abstract_inverted_index.considerable | 128 |
| abstract_inverted_index.demonstrated | 72, 95 |
| abstract_inverted_index.hypertrophy. | 201 |
| abstract_inverted_index.improvements | 150, 231 |
| abstract_inverted_index.monotherapy. | 90, 187 |
| abstract_inverted_index.ameliorations | 129 |
| abstract_inverted_index.hydrochloride | 23 |
| abstract_inverted_index.significantly | 10 |
| abstract_inverted_index.statistically | 111, 148 |
| abstract_inverted_index.child-specific | 242 |
| abstract_inverted_index.well-tolerated | 211 |
| abstract_inverted_index.self-assessment | 126 |
| abstract_inverted_index.well-tolerated, | 174 |
| abstract_inverted_index.treatment-related | 179 |
| abstract_inverted_index.moderate-to-severe | 36, 159, 217 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5098957859, https://openalex.org/A5076198034 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I197809005 |
| citation_normalized_percentile |