Bacteroides ovatus alleviates dysbiotic microbiota-induced intestinal graft-versus-host disease Article Swipe

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Robert R. Jenq , Eiko Hayase , Tomo Hayase , Akash Mukherjee , Stuart C Stinson , Mohamed A. Jamal , Miriam R. Ortega , Christopher A. Sanchez , Saira Ahmed , Jennifer Karmouch , Chia‐Chi Chang , Ivonne I. Flores , Lauren McDaniel , Alexandria Brown , Rawan K. El-Himri , Valerie Chapa , Lin Tan , Bao Tran , Dung Pham , Taylor M. Halsey , Yimei Jin , Wen-Bin Tsai , Rishika Prasad , Israel Glover , Nadim J. Ajami , Jennifer A. Wargo , Samuel A. Shelburne , Pablo C. Okhuysen , Chen Liu , Stephanie Fowler , Margaret E. Conner , Christine B. Peterson , Gabriela Rondón , Jeffrey J. Molldrem , Richard E. Champlin , Elizabeth J. Shpall , Philip L. Lorenzi , Rohtesh S. Mehta , Eric C. Martens , Amin M. Alousi ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.21203/rs.3.rs-2460097/v1

Acute gastrointestinal intestinal GVHD (aGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation, and the intestinal microbiota is known to impact on its severity. However, an association between treatment response of aGI-GVHD and the intestinal microbiota has not been well-studied. In a cohort of patients with aGI-GVHD (n=37), we found that non-response to standard therapy with corticosteroids was associated with prior treatment with carbapenem antibiotics and loss of Bacteroides ovatus from the microbiome. In a mouse model of carbapenem-aggravated GVHD, introducing Bacteroides ovatus reduced severity of GVHD and improved survival. Bacteroides ovatus reduced degradation of colonic mucus by another intestinal commensal, Bacteroides thetaiotaomicron, via its ability to metabolize dietary polysaccharides into monosaccharides, which then inhibit mucus degradation by Bacteroides thetaiotaomicron and reduce GVHD-related mortality.

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Bacteroides Host (biology) Microbiology Disease Graft-versus-host disease Biology Immunology Medicine Bacteria Ecology Internal medicine Genetics

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Type: preprint
Language: en
Landing Page: https://doi.org/10.21203/rs.3.rs-2460097/v1
PDF: https://www.researchsquare.com/article/rs-2460097/latest.pdf
OA Status: gold
Cited By: 6
References: 52
Related Works: 10
OpenAlex ID: https://openalex.org/W4318563491

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DOI: https://doi.org/10.21203/rs.3.rs-2460097/v1

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Title: Bacteroides ovatus alleviates dysbiotic microbiota-induced intestinal graft-versus-host disease

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Type: preprint

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Language: en

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Publication year: 2023

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Publication date: 2023-01-31

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Authors: Robert R. Jenq, Eiko Hayase, Tomo Hayase, Akash Mukherjee, Stuart C Stinson, Mohamed A. Jamal, Miriam R. Ortega, Christopher A. Sanchez, Saira Ahmed, Jennifer Karmouch, Chia‐Chi Chang, Ivonne I. Flores, Lauren McDaniel, Alexandria Brown, Rawan K. El-Himri, Valerie Chapa, Lin Tan, Bao Tran, Dung Pham, Taylor M. Halsey, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Israel Glover, Nadim J. Ajami, Jennifer A. Wargo, Samuel A. Shelburne, Pablo C. Okhuysen, Chen Liu, Stephanie Fowler, Margaret E. Conner, Christine B. Peterson, Gabriela Rondón, Jeffrey J. Molldrem, Richard E. Champlin, Elizabeth J. Shpall, Philip L. Lorenzi, Rohtesh S. Mehta, Eric C. Martens, Amin M. Alousi

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Landing page: https://doi.org/10.21203/rs.3.rs-2460097/v1

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PDF URL: https://www.researchsquare.com/article/rs-2460097/latest.pdf

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OA URL: https://www.researchsquare.com/article/rs-2460097/latest.pdf

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Concepts: Bacteroides, Host (biology), Microbiology, Disease, Graft-versus-host disease, Biology, Immunology, Medicine, Bacteria, Ecology, Internal medicine, Genetics

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Cited by: 6

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