Bariatric Surgery Affects Plasma Levels of Alanine Aminotransferase Independent of Weight Loss: A Registry-Based Study Article Swipe
Shira Azulai
,
Ronit Grinbaum
,
Nahum Beglaibter
,
Shai Meron Eldar
,
Moshe Rubin
,
Shai Carmi
,
Rachel Ben‐Haroush Schyr
,
Orly Romano‐Zelekha
,
Danny Ben‐Zvi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jcm10122724
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jcm10122724
Patients that undergo bariatric surgery experience weight loss and a reduction in the plasma levels of the hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST). We used the Israeli national bariatric registry, which includes demographic, clinical, and biochemical data on 19,403 patients, of which 1335 patients had two-year follow-up data on ALT, AST, A1C, and BMI, to test the dependence of the reduction in the levels of ALT and AST on weight loss. The data were analyzed using regression models, retrospective matching, and time course analyses. Changes in liver enzymes did not correlate with change in BMI, and linear regression models did not demonstrate that the change in ALT and AST values were dependent on pre-operative levels of BMI or the extent of weight loss. ALT and AST levels were reduced two years after surgery compared with a cohort of retrospectively matched patients for ethnicity, sex, age, BMI, and A1C. Finally, patients who regained weight displayed a reduction in levels of liver enzymes. Our results suggest that bariatric surgery affects AST and ALT levels via weight loss dependent and independent mechanisms. Mechanistic studies that will identify the nature of this effect and the clinical relevance of ALT and AST levels to the post-bariatric liver function are warranted.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm10122724
- https://www.mdpi.com/2077-0383/10/12/2724/pdf?version=1624194509
- OA Status
- gold
- Cited By
- 6
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3173811567
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3173811567Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm10122724Digital Object Identifier
- Title
-
Bariatric Surgery Affects Plasma Levels of Alanine Aminotransferase Independent of Weight Loss: A Registry-Based StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-20Full publication date if available
- Authors
-
Shira Azulai, Ronit Grinbaum, Nahum Beglaibter, Shai Meron Eldar, Moshe Rubin, Shai Carmi, Rachel Ben‐Haroush Schyr, Orly Romano‐Zelekha, Danny Ben‐ZviList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm10122724Publisher landing page
- PDF URL
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https://www.mdpi.com/2077-0383/10/12/2724/pdf?version=1624194509Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/10/12/2724/pdf?version=1624194509Direct OA link when available
- Concepts
-
Medicine, Weight loss, Internal medicine, Retrospective cohort study, Alanine aminotransferase, Clinical significance, Alanine transaminase, Gastroenterology, Liver function, Obesity, Cohort, Liver function tests, Body mass index, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
73Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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