Baseline Dual‐Energy Computed Tomography Urate Volume Predicts Fulfillment of Gout Remission After Two Years of Urate‐Lowering Therapy Article Swipe
Adwoa Dansoa Tabi‐Amponsah
,
Sarah Stewart
,
Greg Gamble
,
Anthony Doyle
,
Karen Billington
,
Chang‐Nam Son
,
Kieran Latto
,
Lisa K. Stamp
,
William J. Taylor
,
Anne Horne
,
Nicola Dalbeth
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/acr.25414
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/acr.25414
Objective This study aimed to identify variables that predict gout remission in people with erosive gout receiving urate‐lowering therapy. Methods We analyzed data from a two‐year, double‐masked randomized‐controlled trial of people with erosive gout, randomized to a serum urate target of <0.20 mmol/L or <0.30 mmol/L using oral urate‐lowering therapies. All participants had dual‐energy computed tomography (DECT) scans of the feet and ankles at baseline. The proportion of participants achieving gout remission according to the 2016 preliminary gout remission criteria and simplified gout remission criteria (without the patient reported outcomes) was analyzed. Logistic regression models were used to evaluate predictors of gout remission in year 2. Results The preliminary gout remission criteria were fulfilled in 11 of 97 participants (11%) at year 1 and 21 of 92 participants (23%) at year 2. The simplified criteria were fulfilled in 26 of 97 participants (27%) in year 1 and 40 of 92 participants (44%) in year 2. In multivariable regression models, baseline DECT monosodium urate crystal volume was the only significant independent predictor of gout remission at year 2, using either criteria. Each 1‐cm 3 increase in the baseline DECT monosodium urate crystal volume decreased the odds of fulfilling the 2016 preliminary gout remission criteria (odds ratio [OR] 0.65, 95% confidence interval [CI] 0.46–0.93; P = 0.02) and the simplified gout remission criteria (OR 0.57, 95% CI 0.41–0.78; P < 0.001). Conclusion In people with erosive gout on urate‐lowering therapy, higher baseline DECT monosodium urate crystal volume is associated with lower odds of gout remission after two years of treatment, defined by either the preliminary gout remission criteria or simplified gout remission criteria.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/acr.25414
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acr.25414
- OA Status
- hybrid
- Cited By
- 10
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401552623
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401552623Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/acr.25414Digital Object Identifier
- Title
-
Baseline Dual‐Energy Computed Tomography Urate Volume Predicts Fulfillment of Gout Remission After Two Years of Urate‐Lowering TherapyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-13Full publication date if available
- Authors
-
Adwoa Dansoa Tabi‐Amponsah, Sarah Stewart, Greg Gamble, Anthony Doyle, Karen Billington, Chang‐Nam Son, Kieran Latto, Lisa K. Stamp, William J. Taylor, Anne Horne, Nicola DalbethList of authors in order
- Landing page
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https://doi.org/10.1002/acr.25414Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acr.25414Direct link to full text PDF
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acr.25414Direct OA link when available
- Concepts
-
Gout, Medicine, Hyperuricemia, Internal medicine, Uric acid, Randomized controlled trial, Logistic regression, Odds ratio, Gastroenterology, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.interval | 209 |
| abstract_inverted_index.reported | 88 |
| abstract_inverted_index.therapy, | 237 |
| abstract_inverted_index.therapy. | 18 |
| abstract_inverted_index.Objective | 0 |
| abstract_inverted_index.according | 72 |
| abstract_inverted_index.achieving | 69 |
| abstract_inverted_index.analyzed. | 91 |
| abstract_inverted_index.baseline. | 64 |
| abstract_inverted_index.criteria. | 179, 270 |
| abstract_inverted_index.decreased | 192 |
| abstract_inverted_index.fulfilled | 113, 136 |
| abstract_inverted_index.outcomes) | 89 |
| abstract_inverted_index.predictor | 170 |
| abstract_inverted_index.receiving | 16 |
| abstract_inverted_index.remission | 10, 71, 78, 83, 102, 110, 173, 201, 219, 252, 264, 269 |
| abstract_inverted_index.variables | 6 |
| abstract_inverted_index.Conclusion | 229 |
| abstract_inverted_index.associated | 246 |
| abstract_inverted_index.confidence | 208 |
| abstract_inverted_index.fulfilling | 196 |
| abstract_inverted_index.monosodium | 161, 188, 241 |
| abstract_inverted_index.predictors | 99 |
| abstract_inverted_index.proportion | 66 |
| abstract_inverted_index.randomized | 34 |
| abstract_inverted_index.regression | 93, 157 |
| abstract_inverted_index.simplified | 81, 133, 217, 267 |
| abstract_inverted_index.therapies. | 49 |
| abstract_inverted_index.tomography | 55 |
| abstract_inverted_index.treatment, | 257 |
| abstract_inverted_index.independent | 169 |
| abstract_inverted_index.preliminary | 76, 108, 199, 262 |
| abstract_inverted_index.significant | 168 |
| abstract_inverted_index.two‐year, | 25 |
| abstract_inverted_index.0.41–0.78; | 225 |
| abstract_inverted_index.0.46–0.93; | 211 |
| abstract_inverted_index.participants | 51, 68, 118, 127, 141, 150 |
| abstract_inverted_index.dual‐energy | 53 |
| abstract_inverted_index.multivariable | 156 |
| abstract_inverted_index.double‐masked | 26 |
| abstract_inverted_index.urate‐lowering | 17, 48, 236 |
| abstract_inverted_index.randomized‐controlled | 27 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5086285989 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I154130895 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/7 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Affordable and clean energy |
| citation_normalized_percentile.value | 0.95880068 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |