Baseline prognostic factors and statistic model to predict early virological response in lamivudine-treated patients with chronic hepatitis B. Article Swipe
Rui Zhou
,
Fan Pan
,
Chun Lin
,
Xiuquan Lin
,
Haibing Gao
,
Shuiwen Huang
,
Zuxiong Huang
,
Yong Lin
,
Chen Pan
,
Yuanping Zhou
·
YOU?
·
· 2015
· Open Access
·
YOU?
·
· 2015
· Open Access
·
Lamivudine is a potent nucleoside analogue used in treating chronic hepatitis B (CHB). However, resistance to the drug remains a problem. We analyzed all lamivudine recipients in this trial to determine the baseline characteristics and a model to predict early virological response reflecting the long-term effect of lamivudine. In this prospective trial, 230 patients who had not treated with nucleotide analogue with chronic HBV infection were assigned to receive 100 mg of lamivudine once daily for 24 weeks at least. All patients were followed up every 2 week. Cox proportional hazard regression model analyses were employed to evaluate baseline variables and to develop a statistical model. Female (P = 0.042), baseline higher serum aspartate aminotransferase (AST) (P = 0.002), and lower level of HBV-DNA (P = 0.016) were identified to be associated with higher possibility of early virological response. A model was established based on these variables to calculate the risk scores (R) for CHB patients. R > -0.45 suggested early virological response to lamivudine. The model was validated among an independent set of 40 patients. The gender as well as baseline AST and HBV-DNA levels can predict early virological response. The model provides a better tool for response prediction based on the three prognostic factors.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/26770562
- OA Status
- green
- Cited By
- 3
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2413463798
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2413463798Canonical identifier for this work in OpenAlex
- Title
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Baseline prognostic factors and statistic model to predict early virological response in lamivudine-treated patients with chronic hepatitis B.Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
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2015-01-01Full publication date if available
- Authors
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Rui Zhou, Fan Pan, Chun Lin, Xiuquan Lin, Haibing Gao, Shuiwen Huang, Zuxiong Huang, Yong Lin, Chen Pan, Yuanping ZhouList of authors in order
- Landing page
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https://pubmed.ncbi.nlm.nih.gov/26770562Publisher landing page
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/4694462Direct OA link when available
- Concepts
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Lamivudine, Medicine, Internal medicine, Proportional hazards model, Hazard ratio, Chronic hepatitis, Nucleoside analogue, Gastroenterology, Hepatitis B, Immunology, Nucleoside, Confidence interval, Virus, Chemistry, StereochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2018: 2, 2017: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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