arXiv (Cornell University)
Bayesian Sample Size Calculations for SMART Studies
August 2021 • Armando Turchetta, Erica E. M. Moodie, David A. Stephens, Sylvie Lambert
In the management of most chronic conditions characterized by the lack of universally effective treatments, adaptive treatment strategies (ATSs) have been growing in popularity as they offer a more individualized approach, and sequential multiple assignment randomized trials (SMARTs) have gained attention as the most suitable clinical trial design to formalize the study of these strategies. While the number of SMARTs has increased in recent years, their design has remained limited to the frequentist setting, which…