Bcl2-dependent antineoplastic effects of Calotropis procera root extract against canine mammary tumor cells. Article Swipe
Reza Vahidi
,
Elham Abbasloo
,
Shahabeddin Safi
,
Mahshid Bolourchian
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.30466/vrf.2019.101114.2418
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.30466/vrf.2019.101114.2418
There has been a prevailing trend in the application of herbal medicine as cancer therapeutics. Calotropis procera is an ayurvedic plant applied to ameliorate various illnesses. There is no report on the anti-tumor effects of the root of the plant on canine tumors, although it has been used for the treatment of various diseases in human medicine. The objective of the present study was to investigate the antitumor potential of ethanolic root extract of C. procera against canine mammary tumor cell line (CF41-Mg). MTT, western blot, and flow cytometry assays were carried out to evaluate the possible cytotoxicity and apoptosis induction of the extract. MTT results showed that the extract had a potent cytotoxic activity in a dose-dependent manner with an IC50 of 9.00 μg mL-1. Based on the results of flow cytometry and western blotting, IC50 concentration of the extract induced significant apoptosis in the studied cell line, possibly through down-regulation of Bcl-2 expression. The results of the present study clearly indicated that the root extract of C. procera had promising anti-cancer activity and could be considered as a candidate for the treatment of mammary tumors.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/34345386
- OA Status
- green
- Cited By
- 9
- References
- 24
- Related Works
- 20
- OpenAlex ID
- https://openalex.org/W3181068413
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3181068413Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.30466/vrf.2019.101114.2418Digital Object Identifier
- Title
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Bcl2-dependent antineoplastic effects of Calotropis procera root extract against canine mammary tumor cells.Work title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-01Full publication date if available
- Authors
-
Reza Vahidi, Elham Abbasloo, Shahabeddin Safi, Mahshid BolourchianList of authors in order
- Landing page
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https://pubmed.ncbi.nlm.nih.gov/34345386Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/8328247Direct OA link when available
- Concepts
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Calotropis procera, Procera, Apoptosis, Cytotoxicity, Flow cytometry, MTT assay, Traditional medicine, MCF-7, Pharmacology, Cell culture, Western blot, IC50, Cancer, Biology, Medicine, In vitro, Immunology, Cancer cell, Botany, Biochemistry, Internal medicine, Human breast, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
- Citations by year (recent)
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2024: 3, 2023: 2, 2022: 4Per-year citation counts (last 5 years)
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24Number of works referenced by this work
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20Other works algorithmically related by OpenAlex
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