Beet supplementation mitigates post-exercise inflammation Article Swipe
David C. Nieman
,
Camila A. Sakaguchi
,
James C. Williams
,
Fayaj A. Mulani
,
Patil Shivprasad Suresh
,
Ashraf M. Omar
,
Qibin Zhang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fnut.2024.1408804
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fnut.2024.1408804
Objectives This study investigated the efficacy of a mixed beet-based supplement (BEET) versus placebo (PL) in countering inflammation during recovery from 2.25 h of intensive cycling in 20 male and female cyclists. A multi-omics approach was used that included untargeted proteomics and a targeted oxylipin panel. Methods A randomized, placebo-controlled, double-blind, crossover design was used with two 2-week supplementation periods and a 2-week washout period. Supplementation periods were followed by a 2.25 h cycling bout at close to 70%VO 2max . The BEET supplement provided 212 mg of nitrates per day, 200 mg caffeine from green tea extract, 44 mg vitamin C from Camu Camu berry, B-vitamins from quinoa sprouts (40% Daily Value for thiamin, riboflavin, niacin, and vitamin B6), and 2.5 g of a mushroom blend containing Cordyceps sinensis and Inonotus obliquus. Six blood samples were collected before and after supplementation (overnight fasted state), immediately post-exercise, and at 1.5 h-, 3 h-, and 24 h-post-exercise. Results The 2.25 h cycling bout increased plasma levels of 41 of 67 oxylipins detected. BEET supplementation significantly increased plasma nitrate (NO 3 − ) and nitrite (NO 2 − ) (sum, NO 3 − + NO 2 − ) concentrations (interaction effect, p < 0.001) and two anti-inflammatory oxylipins [18-hydroxyeicosapentaenoic acid (18-HEPE) and 4-hydroxy-docosahexanoic acid (4-HDoHE)]. The untargeted proteomics analysis identified 616 proteins (458 across all times points), and 2-way ANOVA revealed a cluster of 45 proteins that were decreased and a cluster of 21 that were increased in the BEET versus PL trials. Functional enrichment supported significant BEET-related reductions in inflammation-related proteins including several proteins related to complement activation, the acute phase response, and immune cell adhesion, migration, and differentiation. Discussion Intake of a BEET-based supplement during a 2-week period was linked to higher plasma levels of NO 3 − + NO 2 − , elevated post-exercise levels of two anti-inflammatory oxylipins, and a significant decrease in a cluster of proteins involved in complement activation and inflammation. These data support that 2-weeks intake of nitrate from a mixed beet-based supplement moderated protein biomarkers of exercise-induced inflammation in athletes.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnut.2024.1408804
- https://www.frontiersin.org/articles/10.3389/fnut.2024.1408804/pdf?isPublishedV2=False
- OA Status
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- Cited By
- 5
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399186613
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4399186613Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnut.2024.1408804Digital Object Identifier
- Title
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Beet supplementation mitigates post-exercise inflammationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-30Full publication date if available
- Authors
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David C. Nieman, Camila A. Sakaguchi, James C. Williams, Fayaj A. Mulani, Patil Shivprasad Suresh, Ashraf M. Omar, Qibin ZhangList of authors in order
- Landing page
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https://doi.org/10.3389/fnut.2024.1408804Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fnut.2024.1408804/pdf?isPublishedV2=FalseDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fnut.2024.1408804/pdf?isPublishedV2=FalseDirect OA link when available
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Riboflavin, Crossover study, Placebo, Vitamin, Chemistry, Animal science, Food science, Nutraceutical, Internal medicine, Medicine, Biochemistry, Biology, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 3, 2024: 2Per-year citation counts (last 5 years)
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55Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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