Benzodiazepine Use and Risk of Dementia in the Elderly Population: A Systematic Review and Meta-Analysis Article Swipe
Md. Mohaimenul Islam
,
Usman Iqbal
,
Bruno Walther
,
Suleman Atique
,
Navneet Kumar Dubey
,
Phung‐Anh Nguyen
,
Tahmina Nasrin Poly
,
Jakir Hossain Bhuiyan Masud
,
Yu‐Chuan Li
,
Shabbir Syed-Abdul
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1159/000454881
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1159/000454881
Background: Benzodiazepines are a widely used medication in developed countries, particularly among elderly patients. However, benzodiazepines are known to affect memory and cognition and might thus enhance the risk of dementia. The objective of this review is to synthesize evidence from observational studies that evaluated the association between benzodiazepines use and dementia risk. Summary: We performed a systematic review and meta-analysis of controlled observational studies to evaluate the risk of benzodiazepines use on dementia outcome. All control observational studies that compared dementia outcome in patients with benzodiazepine use with a control group were included. We calculated pooled ORs using a random-effects model. Ten studies (of 3,696 studies identified) were included in the systematic review, of which 8 studies were included in random-effects meta-analysis and sensitivity analyses. Odds of dementia were 78% higher in those who used benzodiazepines compared with those who did not use benzodiazepines (OR 1.78; 95% CI 1.33-2.38). In subgroup analysis, the higher association was still found in the studies from Asia (OR 2.40; 95% CI 1.66-3.47) whereas a moderate association was observed in the studies from North America and Europe (OR 1.49; 95% CI 1.34-1.65 and OR 1.43; 95% CI 1.16-1.75). Also, diabetics, hypertension, cardiac disease, and statin drugs were associated with increased risk of dementia but negative association was observed in the case of body mass index. There was significant statistical and clinical heterogeneity among studies for the main analysis and most of the sensitivity analyses. There was significant statistical and clinical heterogeneity among the studies for the main analysis and most of the sensitivity analyses. Key Messages: Our results suggest that benzodiazepine use is significantly associated with dementia risk. However, observational studies cannot clarify whether the observed epidemiologic association is a causal effect or the result of some unmeasured confounding variable. Therefore, more research is needed.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1159/000454881
- https://www.karger.com/Article/Pdf/454881
- OA Status
- bronze
- Cited By
- 205
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2564453682
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2564453682Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1159/000454881Digital Object Identifier
- Title
-
Benzodiazepine Use and Risk of Dementia in the Elderly Population: A Systematic Review and Meta-AnalysisWork title
- Type
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reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-01-01Full publication date if available
- Authors
-
Md. Mohaimenul Islam, Usman Iqbal, Bruno Walther, Suleman Atique, Navneet Kumar Dubey, Phung‐Anh Nguyen, Tahmina Nasrin Poly, Jakir Hossain Bhuiyan Masud, Yu‐Chuan Li, Shabbir Syed-AbdulList of authors in order
- Landing page
-
https://doi.org/10.1159/000454881Publisher landing page
- PDF URL
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https://www.karger.com/Article/Pdf/454881Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.karger.com/Article/Pdf/454881Direct OA link when available
- Concepts
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Medicine, Dementia, Meta-analysis, Population, Systematic review, Benzodiazepine, MEDLINE, Gerontology, Psychiatry, Environmental health, Disease, Internal medicine, Law, Political science, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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205Total citation count in OpenAlex
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2025: 10, 2024: 14, 2023: 18, 2022: 37, 2021: 40Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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