Beyond cellulose: pharmaceutical potential for bioactive plant polysaccharides in treating disease and gut dysbiosis Article Swipe
Yuanlin Niu
,
Wei Liu
,
Xueni Fan
,
Dongxu Wen
,
Dan Wu
,
Hongzhuang Wang
,
Zhenjiang Liu
,
Bin Li
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2023.1183130
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2023.1183130
Polysaccharides derived from plants, algae, or fungi serve as the major components of some human diets. Polysaccharides have been shown to exhibit diverse biological activities in improving human health, and have also been proposed to function as potent modulators of gut microbiota composition, thus playing a bi-directional regulatory role in host health. Here, we review a variety of polysaccharide structures potentially linked to biological functions, and cover current research progress in characterizing their pharmaceutical effects in various disease models, including antioxidant, anticoagulant, anti-inflammatory, immunomodulatory, hypoglycemic, and antimicrobial activities. We also highlight the effects of polysaccharides on modulating gut microbiota via enrichment for beneficial taxa and suppression of potential pathogens, leading to increased microbial expression of carbohydrate-active enzymes and enhanced short chain fatty acid production. This review also discusses polysaccharide-mediated improvements in gut function by influencing interleukin and hormone secretion in host intestinal epithelial cells.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2023.1183130
- https://www.frontiersin.org/articles/10.3389/fmicb.2023.1183130/pdf
- OA Status
- gold
- Cited By
- 14
- References
- 135
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4377942984
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4377942984Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2023.1183130Digital Object Identifier
- Title
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Beyond cellulose: pharmaceutical potential for bioactive plant polysaccharides in treating disease and gut dysbiosisWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-24Full publication date if available
- Authors
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Yuanlin Niu, Wei Liu, Xueni Fan, Dongxu Wen, Dan Wu, Hongzhuang Wang, Zhenjiang Liu, Bin LiList of authors in order
- Landing page
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https://doi.org/10.3389/fmicb.2023.1183130Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fmicb.2023.1183130/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fmicb.2023.1183130/pdfDirect OA link when available
- Concepts
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Gut flora, Polysaccharide, Biology, Dysbiosis, Antimicrobial, Secretion, Function (biology), Biochemistry, Microbiology, Cell biologyTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 9, 2024: 4, 2023: 1Per-year citation counts (last 5 years)
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135Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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