Beyond Discrete Classifications: A Computational Approach to the Continuum of Cognition and Behavior in Children Article Swipe
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.04.14.25325835
Psychiatry is undergoing a shift toward precision medicine, demanding personalized approaches that capture the complexity of cognition and behavior. Here, we introduce a novel referential of four robust, replicable, and generalizable cognitive and behavioral profiles. These were derived from the most prominent pediatric cohort (n=10,843) and validated in two independent cohorts (n=195 and n=271). We demonstrate the profiles’ longitudinal stability and consistency with clinical diagnoses while exposing critical discrepancies across parent-reported, youth-reported, and expert-derived diagnoses. Beyond validation, we showcase the real-world utility of our approach by linking profiles to environmental factors, revealing associations between parental influences and youths’ cognition and behavior. Our fuzzy profiling framework moves beyond discrete classification, offering a powerful tool to refine psychiatric evaluation and intervention. We provide an open-source framework, enabling researchers and clinicians to fast-track implementation and foster a data-driven, domain-based approach to diagnosis. Our findings advocate for broadening the scope of psychiatric assessment.
Related Topics
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.04.14.25325835
- https://www.medrxiv.org/content/medrxiv/early/2025/04/16/2025.04.14.25325835.full.pdf
- OA Status
- green
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409585399
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409585399Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.04.14.25325835Digital Object Identifier
- Title
-
Beyond Discrete Classifications: A Computational Approach to the Continuum of Cognition and Behavior in ChildrenWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-16Full publication date if available
- Authors
-
Anthony Gagnon, Virginie Gillet, Anne-Sandrine Desautels, Jean‐François Lepage, Andrea Baccarelli, Jonathan Posner, Maxime Descoteaux, Marie A. Brunet, Larissa TakserList of authors in order
- Landing page
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https://doi.org/10.1101/2025.04.14.25325835Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2025/04/16/2025.04.14.25325835.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2025/04/16/2025.04.14.25325835.full.pdfDirect OA link when available
- Concepts
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Cognition, Medical diagnosis, Consistency (knowledge bases), Psychology, Cognitive psychology, Computer science, Clinical psychology, Artificial intelligence, Psychiatry, Medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.fuzzy | 103 |
| abstract_inverted_index.moves | 106 |
| abstract_inverted_index.novel | 24 |
| abstract_inverted_index.scope | 146 |
| abstract_inverted_index.shift | 5 |
| abstract_inverted_index.while | 66 |
| abstract_inverted_index.(n=195 | 52 |
| abstract_inverted_index.Beyond | 76 |
| abstract_inverted_index.across | 70 |
| abstract_inverted_index.beyond | 107 |
| abstract_inverted_index.cohort | 44 |
| abstract_inverted_index.foster | 133 |
| abstract_inverted_index.refine | 115 |
| abstract_inverted_index.toward | 6 |
| abstract_inverted_index.between | 94 |
| abstract_inverted_index.capture | 13 |
| abstract_inverted_index.cohorts | 51 |
| abstract_inverted_index.derived | 38 |
| abstract_inverted_index.linking | 87 |
| abstract_inverted_index.n=271). | 54 |
| abstract_inverted_index.provide | 121 |
| abstract_inverted_index.robust, | 28 |
| abstract_inverted_index.utility | 82 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.advocate | 142 |
| abstract_inverted_index.approach | 85, 137 |
| abstract_inverted_index.clinical | 64 |
| abstract_inverted_index.critical | 68 |
| abstract_inverted_index.discrete | 108 |
| abstract_inverted_index.enabling | 125 |
| abstract_inverted_index.exposing | 67 |
| abstract_inverted_index.factors, | 91 |
| abstract_inverted_index.findings | 141 |
| abstract_inverted_index.offering | 110 |
| abstract_inverted_index.parental | 95 |
| abstract_inverted_index.powerful | 112 |
| abstract_inverted_index.profiles | 88 |
| abstract_inverted_index.showcase | 79 |
| abstract_inverted_index.behavior. | 19, 101 |
| abstract_inverted_index.cognition | 17, 99 |
| abstract_inverted_index.cognitive | 32 |
| abstract_inverted_index.demanding | 9 |
| abstract_inverted_index.diagnoses | 65 |
| abstract_inverted_index.framework | 105 |
| abstract_inverted_index.introduce | 22 |
| abstract_inverted_index.medicine, | 8 |
| abstract_inverted_index.pediatric | 43 |
| abstract_inverted_index.precision | 7 |
| abstract_inverted_index.profiles. | 35 |
| abstract_inverted_index.profiling | 104 |
| abstract_inverted_index.prominent | 42 |
| abstract_inverted_index.revealing | 92 |
| abstract_inverted_index.stability | 60 |
| abstract_inverted_index.validated | 47 |
| abstract_inverted_index.youths’ | 98 |
| abstract_inverted_index.(n=10,843) | 45 |
| abstract_inverted_index.Psychiatry | 1 |
| abstract_inverted_index.approaches | 11 |
| abstract_inverted_index.behavioral | 34 |
| abstract_inverted_index.broadening | 144 |
| abstract_inverted_index.clinicians | 128 |
| abstract_inverted_index.complexity | 15 |
| abstract_inverted_index.diagnoses. | 75 |
| abstract_inverted_index.diagnosis. | 139 |
| abstract_inverted_index.evaluation | 117 |
| abstract_inverted_index.fast-track | 130 |
| abstract_inverted_index.framework, | 124 |
| abstract_inverted_index.influences | 96 |
| abstract_inverted_index.real-world | 81 |
| abstract_inverted_index.undergoing | 3 |
| abstract_inverted_index.assessment. | 149 |
| abstract_inverted_index.consistency | 62 |
| abstract_inverted_index.demonstrate | 56 |
| abstract_inverted_index.independent | 50 |
| abstract_inverted_index.open-source | 123 |
| abstract_inverted_index.profiles’ | 58 |
| abstract_inverted_index.psychiatric | 116, 148 |
| abstract_inverted_index.referential | 25 |
| abstract_inverted_index.replicable, | 29 |
| abstract_inverted_index.researchers | 126 |
| abstract_inverted_index.validation, | 77 |
| abstract_inverted_index.associations | 93 |
| abstract_inverted_index.data-driven, | 135 |
| abstract_inverted_index.domain-based | 136 |
| abstract_inverted_index.longitudinal | 59 |
| abstract_inverted_index.personalized | 10 |
| abstract_inverted_index.discrepancies | 69 |
| abstract_inverted_index.environmental | 90 |
| abstract_inverted_index.generalizable | 31 |
| abstract_inverted_index.intervention. | 119 |
| abstract_inverted_index.expert-derived | 74 |
| abstract_inverted_index.implementation | 131 |
| abstract_inverted_index.classification, | 109 |
| abstract_inverted_index.youth-reported, | 72 |
| abstract_inverted_index.parent-reported, | 71 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.13835327 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |