Beyond the VSG Layer: Exploring the Role of Intrinsic Disorder in the Invariant Surface Glycoproteins of African Trypanosomes Article Swipe
Hagen Sülzen
,
Alexander N. Volkov
,
Rob Geens
,
Farnaz Zahedifard
,
Benoı̂t Stijlemans
,
Martin Zoltner
,
Stefan Magez
,
Yann G.‐J. Sterckx
,
Sebastian Zoll
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.12.18.572128
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.12.18.572128
In the bloodstream of mammalian hosts, African trypanosomes face the challenge of protecting their invariant surface receptors from immune detection. This crucial role is fulfilled by a dense, glycosylated protein layer composed of variant surface glycoproteins (VSGs), which undergo antigenic variation and provide a physical barrier that shields the underlying invariant surface glycoproteins (ISGs). The protective shield’s limited permeability comes at the cost of restricted access to the extracellular host environment, raising questions regarding the specific function of the ISG repertoire. In this study, we employ an integrative structural biology approach to show that intrinsically disordered membrane-proximal regions are a common feature of members of the ISG superfamily, conferring the ability to switch between compact and elongated conformers. While the folded, membrane-distal ectodomain is buried within the VSG layer for compact conformers, their elongated counterparts would enable the extension beyond it. This dynamic behavior enables ISGs to maintain a low immunogenic footprint while still allowing them to engage with the host environment when necessary. Our findings add further evidence to a dynamic molecular organization of trypanosome surface antigens wherein intrinsic disorder underpins the characteristics of a highly flexible ISG proteome to circumvent the constraints imposed by the VSG coat.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.12.18.572128
- OA Status
- green
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389912368
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4389912368Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2023.12.18.572128Digital Object Identifier
- Title
-
Beyond the VSG Layer: Exploring the Role of Intrinsic Disorder in the Invariant Surface Glycoproteins of African TrypanosomesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-18Full publication date if available
- Authors
-
Hagen Sülzen, Alexander N. Volkov, Rob Geens, Farnaz Zahedifard, Benoı̂t Stijlemans, Martin Zoltner, Stefan Magez, Yann G.‐J. Sterckx, Sebastian ZollList of authors in order
- Landing page
-
https://doi.org/10.1101/2023.12.18.572128Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1101/2023.12.18.572128Direct OA link when available
- Concepts
-
Ectodomain, Glycoprotein, Biology, Antigenic variation, Cell biology, Epitope, Antigen, Proteome, Computational biology, Receptor, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4389912368 |
|---|---|
| doi | https://doi.org/10.1101/2023.12.18.572128 |
| ids.doi | https://doi.org/10.1101/2023.12.18.572128 |
| ids.openalex | https://openalex.org/W4389912368 |
| fwci | |
| type | preprint |
| title | Beyond the VSG Layer: Exploring the Role of Intrinsic Disorder in the Invariant Surface Glycoproteins of African Trypanosomes |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10890 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Trypanosoma species research and implications |
| topics[1].id | https://openalex.org/T10823 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9976999759674072 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2739 |
| topics[1].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[1].display_name | Research on Leishmaniasis Studies |
| topics[2].id | https://openalex.org/T10993 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9952999949455261 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Complement system in diseases |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C1009742 |
| concepts[0].level | 3 |
| concepts[0].score | 0.9269407391548157 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q5333998 |
| concepts[0].display_name | Ectodomain |
| concepts[1].id | https://openalex.org/C108625454 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7099241018295288 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q187126 |
| concepts[1].display_name | Glycoprotein |
| concepts[2].id | https://openalex.org/C86803240 |
| concepts[2].level | 0 |
| concepts[2].score | 0.6428319215774536 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[2].display_name | Biology |
| concepts[3].id | https://openalex.org/C191942190 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5531220436096191 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q4774739 |
| concepts[3].display_name | Antigenic variation |
| concepts[4].id | https://openalex.org/C95444343 |
| concepts[4].level | 1 |
| concepts[4].score | 0.49636703729629517 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[4].display_name | Cell biology |
| concepts[5].id | https://openalex.org/C195616568 |
| concepts[5].level | 3 |
| concepts[5].score | 0.4545246660709381 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q128711 |
| concepts[5].display_name | Epitope |
| concepts[6].id | https://openalex.org/C147483822 |
| concepts[6].level | 2 |
| concepts[6].score | 0.42494720220565796 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q103537 |
| concepts[6].display_name | Antigen |
| concepts[7].id | https://openalex.org/C104397665 |
| concepts[7].level | 2 |
| concepts[7].score | 0.42023661732673645 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q860947 |
| concepts[7].display_name | Proteome |
| concepts[8].id | https://openalex.org/C70721500 |
| concepts[8].level | 1 |
| concepts[8].score | 0.35003310441970825 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[8].display_name | Computational biology |
| concepts[9].id | https://openalex.org/C170493617 |
| concepts[9].level | 2 |
| concepts[9].score | 0.3365878462791443 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[9].display_name | Receptor |
| concepts[10].id | https://openalex.org/C54355233 |
| concepts[10].level | 1 |
| concepts[10].score | 0.28795334696769714 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[10].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/ectodomain |
| keywords[0].score | 0.9269407391548157 |
| keywords[0].display_name | Ectodomain |
| keywords[1].id | https://openalex.org/keywords/glycoprotein |
| keywords[1].score | 0.7099241018295288 |
| keywords[1].display_name | Glycoprotein |
| keywords[2].id | https://openalex.org/keywords/biology |
| keywords[2].score | 0.6428319215774536 |
| keywords[2].display_name | Biology |
| keywords[3].id | https://openalex.org/keywords/antigenic-variation |
| keywords[3].score | 0.5531220436096191 |
| keywords[3].display_name | Antigenic variation |
| keywords[4].id | https://openalex.org/keywords/cell-biology |
| keywords[4].score | 0.49636703729629517 |
| keywords[4].display_name | Cell biology |
| keywords[5].id | https://openalex.org/keywords/epitope |
| keywords[5].score | 0.4545246660709381 |
| keywords[5].display_name | Epitope |
| keywords[6].id | https://openalex.org/keywords/antigen |
| keywords[6].score | 0.42494720220565796 |
| keywords[6].display_name | Antigen |
| keywords[7].id | https://openalex.org/keywords/proteome |
| keywords[7].score | 0.42023661732673645 |
| keywords[7].display_name | Proteome |
| keywords[8].id | https://openalex.org/keywords/computational-biology |
| keywords[8].score | 0.35003310441970825 |
| keywords[8].display_name | Computational biology |
| keywords[9].id | https://openalex.org/keywords/receptor |
| keywords[9].score | 0.3365878462791443 |
| keywords[9].display_name | Receptor |
| keywords[10].id | https://openalex.org/keywords/genetics |
| keywords[10].score | 0.28795334696769714 |
| keywords[10].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.1101/2023.12.18.572128 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2023.12.18.572128 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5045085520 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7636-700X |
| authorships[0].author.display_name | Hagen Sülzen |
| authorships[0].countries | CZ |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210145889 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti 542/2, 6000, Prague, Czech Republic |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I21250087 |
| authorships[0].affiliations[1].raw_affiliation_string | Faculty of Science, Charles University, Albertov 6, 1800, Prague , Czech Republic |
| authorships[0].institutions[0].id | https://openalex.org/I21250087 |
| authorships[0].institutions[0].ror | https://ror.org/024d6js02 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I21250087 |
| authorships[0].institutions[0].country_code | CZ |
| authorships[0].institutions[0].display_name | Charles University |
| authorships[0].institutions[1].id | https://openalex.org/I4210145889 |
| authorships[0].institutions[1].ror | https://ror.org/04nfjn472 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I202391551, https://openalex.org/I4210145889 |
| authorships[0].institutions[1].country_code | CZ |
| authorships[0].institutions[1].display_name | Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Hagen Sülzen |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Faculty of Science, Charles University, Albertov 6, 1800, Prague , Czech Republic, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti 542/2, 6000, Prague, Czech Republic |
| authorships[1].author.id | https://openalex.org/A5089965799 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-0103-059X |
| authorships[1].author.display_name | Alexander N. Volkov |
| authorships[1].countries | BE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210140355 |
| authorships[1].affiliations[0].raw_affiliation_string | VIB-VUB Center for Structural Biology, Flemish Institute of Biotechnology (VIB), Pleinlaan 2, 1050 Brussels, Belgium |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I13469542 |
| authorships[1].affiliations[1].raw_affiliation_string | Jean Jeener NMR Centre, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium |
| authorships[1].institutions[0].id | https://openalex.org/I4210140355 |
| authorships[1].institutions[0].ror | https://ror.org/03e84cm85 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I13469542, https://openalex.org/I2802017950, https://openalex.org/I4210140355 |
| authorships[1].institutions[0].country_code | BE |
| authorships[1].institutions[0].display_name | VIB-VUB Center for Structural Biology |
| authorships[1].institutions[1].id | https://openalex.org/I13469542 |
| authorships[1].institutions[1].ror | https://ror.org/006e5kg04 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I13469542 |
| authorships[1].institutions[1].country_code | BE |
| authorships[1].institutions[1].display_name | Vrije Universiteit Brussel |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Alexander N. Volkov |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Jean Jeener NMR Centre, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium, VIB-VUB Center for Structural Biology, Flemish Institute of Biotechnology (VIB), Pleinlaan 2, 1050 Brussels, Belgium |
| authorships[2].author.id | https://openalex.org/A5093442124 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Rob Geens |
| authorships[2].countries | BE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210140355 |
| authorships[2].affiliations[0].raw_affiliation_string | VIB-VUB Center for Structural Biology, Flemish Institute of Biotechnology (VIB), Pleinlaan 2, 1050 Brussels, Belgium |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I149213910 |
| authorships[2].affiliations[1].raw_affiliation_string | Laboratory of Medical Biochemistry (LMB) and the Infla-Med Center of Excellence, Department of Pharmaceutical Sciences, Universiteit of Antwerp, B-2610 Wilrijk, Belgium |
| authorships[2].institutions[0].id | https://openalex.org/I149213910 |
| authorships[2].institutions[0].ror | https://ror.org/008x57b05 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I149213910 |
| authorships[2].institutions[0].country_code | BE |
| authorships[2].institutions[0].display_name | University of Antwerp |
| authorships[2].institutions[1].id | https://openalex.org/I4210140355 |
| authorships[2].institutions[1].ror | https://ror.org/03e84cm85 |
| authorships[2].institutions[1].type | facility |
| authorships[2].institutions[1].lineage | https://openalex.org/I13469542, https://openalex.org/I2802017950, https://openalex.org/I4210140355 |
| authorships[2].institutions[1].country_code | BE |
| authorships[2].institutions[1].display_name | VIB-VUB Center for Structural Biology |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Rob Geens |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Laboratory of Medical Biochemistry (LMB) and the Infla-Med Center of Excellence, Department of Pharmaceutical Sciences, Universiteit of Antwerp, B-2610 Wilrijk, Belgium, VIB-VUB Center for Structural Biology, Flemish Institute of Biotechnology (VIB), Pleinlaan 2, 1050 Brussels, Belgium |
| authorships[3].author.id | https://openalex.org/A5080484958 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-3553-0939 |
| authorships[3].author.display_name | Farnaz Zahedifard |
| authorships[3].countries | CZ |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I21250087 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Parasitology, Faculty of Science, Charles University in Prague, Biocev, 25250 Vestec, Czech Republic |
| authorships[3].institutions[0].id | https://openalex.org/I21250087 |
| authorships[3].institutions[0].ror | https://ror.org/024d6js02 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I21250087 |
| authorships[3].institutions[0].country_code | CZ |
| authorships[3].institutions[0].display_name | Charles University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Farnaz Zahedifard |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Parasitology, Faculty of Science, Charles University in Prague, Biocev, 25250 Vestec, Czech Republic |
| authorships[4].author.id | https://openalex.org/A5054193594 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-0082-9751 |
| authorships[4].author.display_name | Benoı̂t Stijlemans |
| authorships[4].countries | BE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I13469542 |
| authorships[4].affiliations[0].raw_affiliation_string | Brussels Center for Immunology (BCIM), Department of Bioengineering Sciences, Vrije Universiteit Brussel, B-1050 Brussels, Belgium |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I4210139803 |
| authorships[4].affiliations[1].raw_affiliation_string | Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, B-1050 Brussels, Belgium |
| authorships[4].institutions[0].id | https://openalex.org/I4210139803 |
| authorships[4].institutions[0].ror | https://ror.org/04q4ydz28 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I2802017950, https://openalex.org/I32597200, https://openalex.org/I4210139803 |
| authorships[4].institutions[0].country_code | BE |
| authorships[4].institutions[0].display_name | VIB-UGent Center for Inflammation Research |
| authorships[4].institutions[1].id | https://openalex.org/I13469542 |
| authorships[4].institutions[1].ror | https://ror.org/006e5kg04 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I13469542 |
| authorships[4].institutions[1].country_code | BE |
| authorships[4].institutions[1].display_name | Vrije Universiteit Brussel |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Benoit Stijlemans |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Brussels Center for Immunology (BCIM), Department of Bioengineering Sciences, Vrije Universiteit Brussel, B-1050 Brussels, Belgium, Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, B-1050 Brussels, Belgium |
| authorships[5].author.id | https://openalex.org/A5067004044 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-0214-285X |
| authorships[5].author.display_name | Martin Zoltner |
| authorships[5].countries | CZ |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I21250087 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Parasitology, Faculty of Science, Charles University in Prague, Biocev, 25250 Vestec, Czech Republic |
| authorships[5].institutions[0].id | https://openalex.org/I21250087 |
| authorships[5].institutions[0].ror | https://ror.org/024d6js02 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I21250087 |
| authorships[5].institutions[0].country_code | CZ |
| authorships[5].institutions[0].display_name | Charles University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Martin Zoltner |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Parasitology, Faculty of Science, Charles University in Prague, Biocev, 25250 Vestec, Czech Republic |
| authorships[6].author.id | https://openalex.org/A5035905258 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-3760-7968 |
| authorships[6].author.display_name | Stefan Magez |
| authorships[6].countries | BE, KR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I13469542 |
| authorships[6].affiliations[0].raw_affiliation_string | Brussels Center for Immunology (BCIM), Department of Bioengineering Sciences, Vrije Universiteit Brussel, B-1050 Brussels, Belgium |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I32597200 |
| authorships[6].affiliations[1].raw_affiliation_string | Department of Biochemistry and Microbiology, Ghent University, B-000 Gent, Belgium |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I4210132857 |
| authorships[6].affiliations[2].raw_affiliation_string | Laboratory for Biomedical Research, Department of Molecular Biotechnology, Environment Technology and Food Technology, Ghent University Global Campus, Incheon 406-840, South Korea |
| authorships[6].institutions[0].id | https://openalex.org/I32597200 |
| authorships[6].institutions[0].ror | https://ror.org/00cv9y106 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I32597200 |
| authorships[6].institutions[0].country_code | BE |
| authorships[6].institutions[0].display_name | Ghent University |
| authorships[6].institutions[1].id | https://openalex.org/I13469542 |
| authorships[6].institutions[1].ror | https://ror.org/006e5kg04 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I13469542 |
| authorships[6].institutions[1].country_code | BE |
| authorships[6].institutions[1].display_name | Vrije Universiteit Brussel |
| authorships[6].institutions[2].id | https://openalex.org/I4210132857 |
| authorships[6].institutions[2].ror | https://ror.org/041bygf77 |
| authorships[6].institutions[2].type | education |
| authorships[6].institutions[2].lineage | https://openalex.org/I32597200, https://openalex.org/I4210132857 |
| authorships[6].institutions[2].country_code | KR |
| authorships[6].institutions[2].display_name | Ghent University Global Campus |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Stefan Magez |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Brussels Center for Immunology (BCIM), Department of Bioengineering Sciences, Vrije Universiteit Brussel, B-1050 Brussels, Belgium, Department of Biochemistry and Microbiology, Ghent University, B-000 Gent, Belgium, Laboratory for Biomedical Research, Department of Molecular Biotechnology, Environment Technology and Food Technology, Ghent University Global Campus, Incheon 406-840, South Korea |
| authorships[7].author.id | https://openalex.org/A5051546583 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7420-0983 |
| authorships[7].author.display_name | Yann G.‐J. Sterckx |
| authorships[7].countries | BE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I149213910 |
| authorships[7].affiliations[0].raw_affiliation_string | Laboratory of Medical Biochemistry (LMB) and the Infla-Med Center of Excellence, Department of Pharmaceutical Sciences, Universiteit of Antwerp, B-2610 Wilrijk, Belgium |
| authorships[7].institutions[0].id | https://openalex.org/I149213910 |
| authorships[7].institutions[0].ror | https://ror.org/008x57b05 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I149213910 |
| authorships[7].institutions[0].country_code | BE |
| authorships[7].institutions[0].display_name | University of Antwerp |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Yann G.-J. Sterckx |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Laboratory of Medical Biochemistry (LMB) and the Infla-Med Center of Excellence, Department of Pharmaceutical Sciences, Universiteit of Antwerp, B-2610 Wilrijk, Belgium |
| authorships[8].author.id | https://openalex.org/A5083443139 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-5376-9698 |
| authorships[8].author.display_name | Sebastian Zoll |
| authorships[8].countries | CZ |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210145889 |
| authorships[8].affiliations[0].raw_affiliation_string | Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti 542/2, 6000, Prague, Czech Republic |
| authorships[8].institutions[0].id | https://openalex.org/I4210145889 |
| authorships[8].institutions[0].ror | https://ror.org/04nfjn472 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I202391551, https://openalex.org/I4210145889 |
| authorships[8].institutions[0].country_code | CZ |
| authorships[8].institutions[0].display_name | Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Sebastian Zoll |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti 542/2, 6000, Prague, Czech Republic |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1101/2023.12.18.572128 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Beyond the VSG Layer: Exploring the Role of Intrinsic Disorder in the Invariant Surface Glycoproteins of African Trypanosomes |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10890 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Trypanosoma species research and implications |
| related_works | https://openalex.org/W2046666360, https://openalex.org/W4405878288, https://openalex.org/W1995181927, https://openalex.org/W1978000202, https://openalex.org/W4307966890, https://openalex.org/W3119217360, https://openalex.org/W2318532368, https://openalex.org/W2013466762, https://openalex.org/W2070496308, https://openalex.org/W2317287878 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2023.12.18.572128 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2023.12.18.572128 |
| primary_location.id | doi:10.1101/2023.12.18.572128 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2023.12.18.572128 |
| publication_date | 2023-12-18 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W1997323235, https://openalex.org/W1560190501, https://openalex.org/W2800215167, https://openalex.org/W2046042613, https://openalex.org/W2073270418, https://openalex.org/W4293503604, https://openalex.org/W4367181522, https://openalex.org/W2899045680, https://openalex.org/W2873994807, https://openalex.org/W2074701664, https://openalex.org/W2903103803, https://openalex.org/W2237583164, https://openalex.org/W2593479908, https://openalex.org/W1578142238, https://openalex.org/W1996860074, https://openalex.org/W1575045684, https://openalex.org/W2014407054, https://openalex.org/W2754868622, https://openalex.org/W2123840180, https://openalex.org/W2028356785, https://openalex.org/W1506602661, https://openalex.org/W2129065810, https://openalex.org/W2025277548, https://openalex.org/W4387016849, https://openalex.org/W2094421748, https://openalex.org/W3195203392, https://openalex.org/W2143381397, https://openalex.org/W4361255794, https://openalex.org/W4320489363, https://openalex.org/W4220696131, https://openalex.org/W2084692275, https://openalex.org/W3212400300, https://openalex.org/W4313332450, https://openalex.org/W2070395446, https://openalex.org/W2781364521, https://openalex.org/W2753348948, https://openalex.org/W3109413273, https://openalex.org/W3177828909, https://openalex.org/W3202105508, https://openalex.org/W2148557238, https://openalex.org/W2061506539, https://openalex.org/W2346627216, https://openalex.org/W4387164156, https://openalex.org/W4386356999, https://openalex.org/W4308688290, https://openalex.org/W2094077114, https://openalex.org/W2004242436, https://openalex.org/W3183475563, https://openalex.org/W2955168413, https://openalex.org/W3186179742, https://openalex.org/W4385683583, https://openalex.org/W4387113560, https://openalex.org/W4387934645, https://openalex.org/W2054068963, https://openalex.org/W3209368428, https://openalex.org/W2060007690, https://openalex.org/W2069590064, https://openalex.org/W2118118022, https://openalex.org/W2035989713, https://openalex.org/W3106000014 |
| referenced_works_count | 60 |
| abstract_inverted_index.a | 27, 44, 100, 149, 171, 186 |
| abstract_inverted_index.In | 1, 82 |
| abstract_inverted_index.an | 87 |
| abstract_inverted_index.at | 61 |
| abstract_inverted_index.by | 26, 196 |
| abstract_inverted_index.is | 24, 124 |
| abstract_inverted_index.of | 4, 12, 33, 64, 78, 103, 105, 175, 185 |
| abstract_inverted_index.to | 67, 92, 112, 147, 157, 170, 191 |
| abstract_inverted_index.we | 85 |
| abstract_inverted_index.ISG | 80, 107, 189 |
| abstract_inverted_index.Our | 165 |
| abstract_inverted_index.The | 55 |
| abstract_inverted_index.VSG | 128, 198 |
| abstract_inverted_index.add | 167 |
| abstract_inverted_index.and | 42, 116 |
| abstract_inverted_index.are | 99 |
| abstract_inverted_index.for | 130 |
| abstract_inverted_index.it. | 141 |
| abstract_inverted_index.low | 150 |
| abstract_inverted_index.the | 2, 10, 49, 62, 68, 75, 79, 106, 110, 120, 127, 138, 160, 183, 193, 197 |
| abstract_inverted_index.ISGs | 146 |
| abstract_inverted_index.This | 21, 142 |
| abstract_inverted_index.cost | 63 |
| abstract_inverted_index.face | 9 |
| abstract_inverted_index.from | 18 |
| abstract_inverted_index.host | 70, 161 |
| abstract_inverted_index.role | 23 |
| abstract_inverted_index.show | 93 |
| abstract_inverted_index.that | 47, 94 |
| abstract_inverted_index.them | 156 |
| abstract_inverted_index.this | 83 |
| abstract_inverted_index.when | 163 |
| abstract_inverted_index.with | 159 |
| abstract_inverted_index.While | 119 |
| abstract_inverted_index.coat. | 199 |
| abstract_inverted_index.comes | 60 |
| abstract_inverted_index.layer | 31, 129 |
| abstract_inverted_index.still | 154 |
| abstract_inverted_index.their | 14, 133 |
| abstract_inverted_index.which | 38 |
| abstract_inverted_index.while | 153 |
| abstract_inverted_index.would | 136 |
| abstract_inverted_index.access | 66 |
| abstract_inverted_index.beyond | 140 |
| abstract_inverted_index.buried | 125 |
| abstract_inverted_index.common | 101 |
| abstract_inverted_index.dense, | 28 |
| abstract_inverted_index.employ | 86 |
| abstract_inverted_index.enable | 137 |
| abstract_inverted_index.engage | 158 |
| abstract_inverted_index.highly | 187 |
| abstract_inverted_index.hosts, | 6 |
| abstract_inverted_index.immune | 19 |
| abstract_inverted_index.study, | 84 |
| abstract_inverted_index.switch | 113 |
| abstract_inverted_index.within | 126 |
| abstract_inverted_index.(ISGs). | 54 |
| abstract_inverted_index.(VSGs), | 37 |
| abstract_inverted_index.African | 7 |
| abstract_inverted_index.ability | 111 |
| abstract_inverted_index.barrier | 46 |
| abstract_inverted_index.between | 114 |
| abstract_inverted_index.biology | 90 |
| abstract_inverted_index.compact | 115, 131 |
| abstract_inverted_index.crucial | 22 |
| abstract_inverted_index.dynamic | 143, 172 |
| abstract_inverted_index.enables | 145 |
| abstract_inverted_index.feature | 102 |
| abstract_inverted_index.folded, | 121 |
| abstract_inverted_index.further | 168 |
| abstract_inverted_index.imposed | 195 |
| abstract_inverted_index.limited | 58 |
| abstract_inverted_index.members | 104 |
| abstract_inverted_index.protein | 30 |
| abstract_inverted_index.provide | 43 |
| abstract_inverted_index.raising | 72 |
| abstract_inverted_index.regions | 98 |
| abstract_inverted_index.shields | 48 |
| abstract_inverted_index.surface | 16, 35, 52, 177 |
| abstract_inverted_index.undergo | 39 |
| abstract_inverted_index.variant | 34 |
| abstract_inverted_index.wherein | 179 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.allowing | 155 |
| abstract_inverted_index.antigens | 178 |
| abstract_inverted_index.approach | 91 |
| abstract_inverted_index.behavior | 144 |
| abstract_inverted_index.composed | 32 |
| abstract_inverted_index.disorder | 181 |
| abstract_inverted_index.evidence | 169 |
| abstract_inverted_index.findings | 166 |
| abstract_inverted_index.flexible | 188 |
| abstract_inverted_index.function | 77 |
| abstract_inverted_index.maintain | 148 |
| abstract_inverted_index.physical | 45 |
| abstract_inverted_index.proteome | 190 |
| abstract_inverted_index.specific | 76 |
| abstract_inverted_index.antigenic | 40 |
| abstract_inverted_index.challenge | 11 |
| abstract_inverted_index.elongated | 117, 134 |
| abstract_inverted_index.extension | 139 |
| abstract_inverted_index.footprint | 152 |
| abstract_inverted_index.fulfilled | 25 |
| abstract_inverted_index.intrinsic | 180 |
| abstract_inverted_index.invariant | 15, 51 |
| abstract_inverted_index.mammalian | 5 |
| abstract_inverted_index.molecular | 173 |
| abstract_inverted_index.questions | 73 |
| abstract_inverted_index.receptors | 17 |
| abstract_inverted_index.regarding | 74 |
| abstract_inverted_index.underpins | 182 |
| abstract_inverted_index.variation | 41 |
| abstract_inverted_index.circumvent | 192 |
| abstract_inverted_index.conferring | 109 |
| abstract_inverted_index.detection. | 20 |
| abstract_inverted_index.disordered | 96 |
| abstract_inverted_index.ectodomain | 123 |
| abstract_inverted_index.necessary. | 164 |
| abstract_inverted_index.protecting | 13 |
| abstract_inverted_index.protective | 56 |
| abstract_inverted_index.restricted | 65 |
| abstract_inverted_index.shield’s | 57 |
| abstract_inverted_index.structural | 89 |
| abstract_inverted_index.underlying | 50 |
| abstract_inverted_index.bloodstream | 3 |
| abstract_inverted_index.conformers, | 132 |
| abstract_inverted_index.conformers. | 118 |
| abstract_inverted_index.constraints | 194 |
| abstract_inverted_index.environment | 162 |
| abstract_inverted_index.immunogenic | 151 |
| abstract_inverted_index.integrative | 88 |
| abstract_inverted_index.repertoire. | 81 |
| abstract_inverted_index.trypanosome | 176 |
| abstract_inverted_index.counterparts | 135 |
| abstract_inverted_index.environment, | 71 |
| abstract_inverted_index.glycosylated | 29 |
| abstract_inverted_index.organization | 174 |
| abstract_inverted_index.permeability | 59 |
| abstract_inverted_index.superfamily, | 108 |
| abstract_inverted_index.trypanosomes | 8 |
| abstract_inverted_index.extracellular | 69 |
| abstract_inverted_index.glycoproteins | 36, 53 |
| abstract_inverted_index.intrinsically | 95 |
| abstract_inverted_index.characteristics | 184 |
| abstract_inverted_index.membrane-distal | 122 |
| abstract_inverted_index.membrane-proximal | 97 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5083443139, https://openalex.org/A5051546583 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I149213910, https://openalex.org/I4210145889 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.5600000023841858 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.34885736 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |