Bi-directional command of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum Article Swipe
Sybren F. de Kloet
,
Bastiaan Bruinsma
,
Huub Terra
,
Tim S. Heistek
,
Emma M. J. Passchier
,
Alexandra van den Berg
,
Antonio Luchicchi
,
Rogier Min
,
Tommy Pattij
,
Huibert D. Mansvelder
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-88545/v1
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-88545/v1
The medial prefrontal cortex (mPFC) steers goal-directed actions and withholds inappropriate behavior. Dorsal and ventral mPFC (dmPFC/vmPFC) circuits have distinct roles in cognitive control, but underlying mechanisms are poorly understood. In this study, we provide anatomical, behavioral, and neurophysiological evidence for distinct roles of four distinct prefrontal projection populations in behavior. We used neuroanatomical tracing techniques, chemogenetics and fiber photometry in freely behaving rats, and in vitro electrophysiology to characterize dmPFC and vmPFC outputs to distinct thalamic and striatal subdomains and show that they have dissociable roles in cognitive control. We identify four spatially segregated projection neuron populations in the mPFC. Chemogenetic silencing shows that dmPFC and vmPFC projections to lateral and medial mediodorsal thalamus subregions oppositely regulate cognitive control. In addition, superficial and deep layer dmPFC neurons projecting to striatum and thalamus divergently regulate cognitive control. Using fiber photometry, we show that these projections distinctly encode behavior. Finally, we show that postsynaptic striatal and thalamic neurons differentially process synaptic inputs from dmPFC and vmPFC, highlighting mechanisms that potentially amplify distinct pathways underlying cognitive control of behavior. Collectively, we show that mPFC output circuits targeting anatomically and functionally distinct striatal and thalamic subregions encode bidirectional command of cognitive control.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-88545/v1
- OA Status
- green
- Cited By
- 2
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4214647442
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4214647442Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-88545/v1Digital Object Identifier
- Title
-
Bi-directional command of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatumWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-10-21Full publication date if available
- Authors
-
Sybren F. de Kloet, Bastiaan Bruinsma, Huub Terra, Tim S. Heistek, Emma M. J. Passchier, Alexandra van den Berg, Antonio Luchicchi, Rogier Min, Tommy Pattij, Huibert D. MansvelderList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-88545/v1Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.21203/rs.3.rs-88545/v1Direct OA link when available
- Concepts
-
Striatum, Thalamus, Neuroscience, Prefrontal cortex, Cognition, Psychology, Cognitive psychology, Computer science, DopamineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1Per-year citation counts (last 5 years)
- Related works (count)
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10Other works algorithmically related by OpenAlex
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