Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity Article Swipe
Rômulo Silva de Oliveira
,
Angela Shupe
,
Tim Johannes Krause
,
Timmy Richardo
,
Christina Ohland
,
Mahana Sabachvili
,
Kirsten Bucher
,
Jenny Hetzer
,
Sebastian Hörner
,
Daniel Dauch
,
Mathias Heikenwälder
,
Christoph Trautwein
,
Alexander N.R. Weber
,
Victoria Klepsch
,
Kathy D. McCoy
,
Lukas F. Mager
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.116223
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.116223
While several phylogenetically distinct bacterial taxa can predict responses to or improve cancer immunotherapies, the underlying mechanisms remain poorly understood. The use of microbes for microbial therapeutics is currently under intense research, yet safety and regulatory hurdles remain challenging. Thus, non-replicative bacterial-derived molecules or extracts provide promising alternatives. We have identified exopolysaccharides (EPSs) from two bacterial species-Bifidobacterium pseudolongum and Bifidobacterium pseudocatenulatum-that promote anti-tumor immunity. EPS improved Th1 T cell immunity, which was further boosted by the metabolite inosine. Mechanistically, EPS was sensed by dendritic cells in a Tlr2-MyD88-dependent manner, which induced interleukin (IL)-12 and tumor necrosis factor (TNF)-α. Both cytokines were required for T cell-dependent killing of tumor cells in murine colon cancer models. EPS stimulated IL-12 production through Toll-like receptor 2 (TLR2) in human dendritic cells and promoted cell death in patient-derived colon cancer organoids through immune cells. Collectively, our study identifies microbe-derived EPS as an adjuvant immunotherapy in cancer.
Related Topics
Concepts
Immunity
Biology
Tumor immunology
Immune system
Cancer research
Microbiology
Chemistry
Cell biology
Immunology
Immunotherapy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.celrep.2025.116223
- OA Status
- gold
- Cited By
- 1
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413883727
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413883727Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.celrep.2025.116223Digital Object Identifier
- Title
-
Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-01Full publication date if available
- Authors
-
Rômulo Silva de Oliveira, Angela Shupe, Tim Johannes Krause, Timmy Richardo, Christina Ohland, Mahana Sabachvili, Kirsten Bucher, Jenny Hetzer, Sebastian Hörner, Daniel Dauch, Mathias Heikenwälder, Christoph Trautwein, Alexander N.R. Weber, Victoria Klepsch, Kathy D. McCoy, Lukas F. MagerList of authors in order
- Landing page
-
https://doi.org/10.1016/j.celrep.2025.116223Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.celrep.2025.116223Direct OA link when available
- Concepts
-
Immunity, Biology, Tumor immunology, Immune system, Cancer research, Microbiology, Chemistry, Cell biology, Immunology, ImmunotherapyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4413883727 |
|---|---|
| doi | https://doi.org/10.1016/j.celrep.2025.116223 |
| ids.doi | https://doi.org/10.1016/j.celrep.2025.116223 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40892540 |
| ids.openalex | https://openalex.org/W4413883727 |
| fwci | 4.35106385 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D001644 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Bifidobacterium |
| mesh[2].qualifier_ui | Q000737 |
| mesh[2].descriptor_ui | D001644 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | chemistry |
| mesh[2].descriptor_name | Bifidobacterium |
| mesh[3].qualifier_ui | Q000494 |
| mesh[3].descriptor_ui | D011135 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | pharmacology |
| mesh[3].descriptor_name | Polysaccharides, Bacterial |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D006801 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Humans |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D051195 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Toll-Like Receptor 2 |
| mesh[6].qualifier_ui | Q000276 |
| mesh[6].descriptor_ui | D003713 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | immunology |
| mesh[6].descriptor_name | Dendritic Cells |
| mesh[7].qualifier_ui | Q000187 |
| mesh[7].descriptor_ui | D003713 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | drug effects |
| mesh[7].descriptor_name | Dendritic Cells |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D003713 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Dendritic Cells |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D051379 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Mice |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D018664 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Interleukin-12 |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008810 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Mice, Inbred C57BL |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D053594 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Myeloid Differentiation Factor 88 |
| mesh[13].qualifier_ui | Q000276 |
| mesh[13].descriptor_ui | D003110 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | immunology |
| mesh[13].descriptor_name | Colonic Neoplasms |
| mesh[14].qualifier_ui | Q000473 |
| mesh[14].descriptor_ui | D003110 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | pathology |
| mesh[14].descriptor_name | Colonic Neoplasms |
| mesh[15].qualifier_ui | Q000276 |
| mesh[15].descriptor_ui | D018417 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | immunology |
| mesh[15].descriptor_name | Th1 Cells |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D045744 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Cell Line, Tumor |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D014409 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Tumor Necrosis Factor-alpha |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D007167 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Immunotherapy |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D000818 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Animals |
| mesh[20].qualifier_ui | Q000378 |
| mesh[20].descriptor_ui | D001644 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | metabolism |
| mesh[20].descriptor_name | Bifidobacterium |
| mesh[21].qualifier_ui | Q000737 |
| mesh[21].descriptor_ui | D001644 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | chemistry |
| mesh[21].descriptor_name | Bifidobacterium |
| mesh[22].qualifier_ui | Q000494 |
| mesh[22].descriptor_ui | D011135 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | pharmacology |
| mesh[22].descriptor_name | Polysaccharides, Bacterial |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D006801 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Humans |
| mesh[24].qualifier_ui | Q000378 |
| mesh[24].descriptor_ui | D051195 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | metabolism |
| mesh[24].descriptor_name | Toll-Like Receptor 2 |
| mesh[25].qualifier_ui | Q000276 |
| mesh[25].descriptor_ui | D003713 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | immunology |
| mesh[25].descriptor_name | Dendritic Cells |
| mesh[26].qualifier_ui | Q000187 |
| mesh[26].descriptor_ui | D003713 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | drug effects |
| mesh[26].descriptor_name | Dendritic Cells |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D003713 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | Dendritic Cells |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D051379 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Mice |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D018664 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | Interleukin-12 |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D008810 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Mice, Inbred C57BL |
| mesh[31].qualifier_ui | Q000378 |
| mesh[31].descriptor_ui | D053594 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | metabolism |
| mesh[31].descriptor_name | Myeloid Differentiation Factor 88 |
| mesh[32].qualifier_ui | Q000276 |
| mesh[32].descriptor_ui | D003110 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | immunology |
| mesh[32].descriptor_name | Colonic Neoplasms |
| mesh[33].qualifier_ui | Q000473 |
| mesh[33].descriptor_ui | D003110 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | pathology |
| mesh[33].descriptor_name | Colonic Neoplasms |
| mesh[34].qualifier_ui | Q000276 |
| mesh[34].descriptor_ui | D018417 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | immunology |
| mesh[34].descriptor_name | Th1 Cells |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D045744 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Cell Line, Tumor |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D014409 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Tumor Necrosis Factor-alpha |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D007167 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Immunotherapy |
| type | article |
| title | Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity |
| biblio.issue | 9 |
| biblio.volume | 44 |
| biblio.last_page | 116223 |
| biblio.first_page | 116223 |
| topics[0].id | https://openalex.org/T12996 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9990000128746033 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1305 |
| topics[0].subfield.display_name | Biotechnology |
| topics[0].display_name | Cancer Research and Treatments |
| topics[1].id | https://openalex.org/T10066 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9975000023841858 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Gut microbiota and health |
| topics[2].id | https://openalex.org/T10141 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.9947999715805054 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1106 |
| topics[2].subfield.display_name | Food Science |
| topics[2].display_name | Probiotics and Fermented Foods |
| is_xpac | False |
| apc_list.value | 5200 |
| apc_list.currency | USD |
| apc_list.value_usd | 5200 |
| apc_paid.value | 5200 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 5200 |
| concepts[0].id | https://openalex.org/C2779341262 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7316946983337402 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q182581 |
| concepts[0].display_name | Immunity |
| concepts[1].id | https://openalex.org/C86803240 |
| concepts[1].level | 0 |
| concepts[1].score | 0.46103692054748535 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[1].display_name | Biology |
| concepts[2].id | https://openalex.org/C3017712846 |
| concepts[2].level | 4 |
| concepts[2].score | 0.43786484003067017 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q4891747 |
| concepts[2].display_name | Tumor immunology |
| concepts[3].id | https://openalex.org/C8891405 |
| concepts[3].level | 2 |
| concepts[3].score | 0.4336748421192169 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[3].display_name | Immune system |
| concepts[4].id | https://openalex.org/C502942594 |
| concepts[4].level | 1 |
| concepts[4].score | 0.3944246172904968 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[4].display_name | Cancer research |
| concepts[5].id | https://openalex.org/C89423630 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3878726065158844 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7193 |
| concepts[5].display_name | Microbiology |
| concepts[6].id | https://openalex.org/C185592680 |
| concepts[6].level | 0 |
| concepts[6].score | 0.3530419170856476 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[6].display_name | Chemistry |
| concepts[7].id | https://openalex.org/C95444343 |
| concepts[7].level | 1 |
| concepts[7].score | 0.3522093892097473 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[7].display_name | Cell biology |
| concepts[8].id | https://openalex.org/C203014093 |
| concepts[8].level | 1 |
| concepts[8].score | 0.2980327010154724 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[8].display_name | Immunology |
| concepts[9].id | https://openalex.org/C2777701055 |
| concepts[9].level | 3 |
| concepts[9].score | 0.18490657210350037 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1427096 |
| concepts[9].display_name | Immunotherapy |
| keywords[0].id | https://openalex.org/keywords/immunity |
| keywords[0].score | 0.7316946983337402 |
| keywords[0].display_name | Immunity |
| keywords[1].id | https://openalex.org/keywords/biology |
| keywords[1].score | 0.46103692054748535 |
| keywords[1].display_name | Biology |
| keywords[2].id | https://openalex.org/keywords/tumor-immunology |
| keywords[2].score | 0.43786484003067017 |
| keywords[2].display_name | Tumor immunology |
| keywords[3].id | https://openalex.org/keywords/immune-system |
| keywords[3].score | 0.4336748421192169 |
| keywords[3].display_name | Immune system |
| keywords[4].id | https://openalex.org/keywords/cancer-research |
| keywords[4].score | 0.3944246172904968 |
| keywords[4].display_name | Cancer research |
| keywords[5].id | https://openalex.org/keywords/microbiology |
| keywords[5].score | 0.3878726065158844 |
| keywords[5].display_name | Microbiology |
| keywords[6].id | https://openalex.org/keywords/chemistry |
| keywords[6].score | 0.3530419170856476 |
| keywords[6].display_name | Chemistry |
| keywords[7].id | https://openalex.org/keywords/cell-biology |
| keywords[7].score | 0.3522093892097473 |
| keywords[7].display_name | Cell biology |
| keywords[8].id | https://openalex.org/keywords/immunology |
| keywords[8].score | 0.2980327010154724 |
| keywords[8].display_name | Immunology |
| keywords[9].id | https://openalex.org/keywords/immunotherapy |
| keywords[9].score | 0.18490657210350037 |
| keywords[9].display_name | Immunotherapy |
| language | en |
| locations[0].id | doi:10.1016/j.celrep.2025.116223 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S169236886 |
| locations[0].source.issn | 2211-1247, 2639-1856 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2211-1247 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Cell Reports |
| locations[0].source.host_organization | https://openalex.org/P4310315673 |
| locations[0].source.host_organization_name | Cell Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315673 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cell Reports |
| locations[0].landing_page_url | https://doi.org/10.1016/j.celrep.2025.116223 |
| locations[1].id | pmid:40892540 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cell reports |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40892540 |
| locations[2].id | pmh:oai:doaj.org/article:8151e593495644b7bd8348349ff227ce |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Cell Reports, Vol 44, Iss 9, Pp 116223- (2025) |
| locations[2].landing_page_url | https://doaj.org/article/8151e593495644b7bd8348349ff227ce |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5080751827 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8853-9021 |
| authorships[0].author.display_name | Rômulo Silva de Oliveira |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[0].affiliations[0].raw_affiliation_string | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany. |
| authorships[0].institutions[0].id | https://openalex.org/I8087733 |
| authorships[0].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | University of Tübingen |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Rômulo Silva de Oliveira |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany. |
| authorships[1].author.id | https://openalex.org/A5018961212 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Angela Shupe |
| authorships[1].countries | CA |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I168635309 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. |
| authorships[1].institutions[0].id | https://openalex.org/I168635309 |
| authorships[1].institutions[0].ror | https://ror.org/03yjb2x39 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I168635309 |
| authorships[1].institutions[0].country_code | CA |
| authorships[1].institutions[0].display_name | University of Calgary |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Amy Shupe |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. |
| authorships[2].author.id | https://openalex.org/A5028953608 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Tim Johannes Krause |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[2].affiliations[0].raw_affiliation_string | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany. |
| authorships[2].institutions[0].id | https://openalex.org/I8087733 |
| authorships[2].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | University of Tübingen |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Tim Krause |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany. |
| authorships[3].author.id | https://openalex.org/A5058743801 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-4927-2715 |
| authorships[3].author.display_name | Timmy Richardo |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[3].affiliations[0].raw_affiliation_string | Institute of Immunology, Department of Innate Immunity, University of Tübingen, Tübingen, Germany. |
| authorships[3].institutions[0].id | https://openalex.org/I8087733 |
| authorships[3].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | University of Tübingen |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Timmy Richardo |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institute of Immunology, Department of Innate Immunity, University of Tübingen, Tübingen, Germany. |
| authorships[4].author.id | https://openalex.org/A5069286971 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-2854-8214 |
| authorships[4].author.display_name | Christina Ohland |
| authorships[4].countries | CA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I168635309 |
| authorships[4].affiliations[0].raw_affiliation_string | International Microbiome Centre, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. |
| authorships[4].institutions[0].id | https://openalex.org/I168635309 |
| authorships[4].institutions[0].ror | https://ror.org/03yjb2x39 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I168635309 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | University of Calgary |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Christina Ohland |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | International Microbiome Centre, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. |
| authorships[5].author.id | https://openalex.org/A5115831926 |
| authorships[5].author.orcid | https://orcid.org/0009-0000-9480-834X |
| authorships[5].author.display_name | Mahana Sabachvili |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[5].affiliations[0].raw_affiliation_string | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany. |
| authorships[5].institutions[0].id | https://openalex.org/I8087733 |
| authorships[5].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | University of Tübingen |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Mahana Sabachvili |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany. |
| authorships[6].author.id | https://openalex.org/A5016223449 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-4746-6337 |
| authorships[6].author.display_name | Kirsten Bucher |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[6].affiliations[0].raw_affiliation_string | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany. |
| authorships[6].institutions[0].id | https://openalex.org/I8087733 |
| authorships[6].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | University of Tübingen |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Kirsten Bucher |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany. |
| authorships[7].author.id | https://openalex.org/A5065565995 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Jenny Hetzer |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[7].affiliations[0].raw_affiliation_string | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany. |
| authorships[7].institutions[0].id | https://openalex.org/I8087733 |
| authorships[7].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | University of Tübingen |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Jenny Hetzer |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany. |
| authorships[8].author.id | https://openalex.org/A5044163250 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-8023-4258 |
| authorships[8].author.display_name | Sebastian Hörner |
| authorships[8].affiliations[0].raw_affiliation_string | German Cancer Consortium (DKTK), Partner Site Tübingen, a Partnership Between DKFZ and University Hospital Tübingen, Tübingen, Germany; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany. |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Sebastian Hörner |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | German Cancer Consortium (DKTK), Partner Site Tübingen, a Partnership Between DKFZ and University Hospital Tübingen, Tübingen, Germany; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany. |
| authorships[9].author.id | https://openalex.org/A5077726833 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-9805-5784 |
| authorships[9].author.display_name | Daniel Dauch |
| authorships[9].countries | DE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany. |
| authorships[9].institutions[0].id | https://openalex.org/I8087733 |
| authorships[9].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[9].institutions[0].country_code | DE |
| authorships[9].institutions[0].display_name | University of Tübingen |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Daniel Dauch |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany. |
| authorships[10].author.id | https://openalex.org/A5022155277 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-3135-2274 |
| authorships[10].author.display_name | Mathias Heikenwälder |
| authorships[10].countries | DE |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[10].affiliations[0].raw_affiliation_string | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany. |
| authorships[10].institutions[0].id | https://openalex.org/I8087733 |
| authorships[10].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[10].institutions[0].country_code | DE |
| authorships[10].institutions[0].display_name | University of Tübingen |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Mathias Heikenwälder |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany. |
| authorships[11].author.id | https://openalex.org/A5048032356 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-4672-6395 |
| authorships[11].author.display_name | Christoph Trautwein |
| authorships[11].countries | DE |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[11].affiliations[0].raw_affiliation_string | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University Hospital Tübingen, Tübingen, Germany. |
| authorships[11].institutions[0].id | https://openalex.org/I8087733 |
| authorships[11].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[11].institutions[0].country_code | DE |
| authorships[11].institutions[0].display_name | University of Tübingen |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Christoph Trautwein |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University Hospital Tübingen, Tübingen, Germany. |
| authorships[12].author.id | https://openalex.org/A5027231761 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-8627-7056 |
| authorships[12].author.display_name | Alexander N.R. Weber |
| authorships[12].countries | DE |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I8087733 |
| authorships[12].affiliations[0].raw_affiliation_string | Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany; Institute of Immunology, Department of Innate Immunity, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), Partner Site Tübingen, a Partnership Between DKFZ and University Hospital Tübingen, Tübingen, Germany; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany. |
| authorships[12].institutions[0].id | https://openalex.org/I8087733 |
| authorships[12].institutions[0].ror | https://ror.org/03a1kwz48 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I8087733 |
| authorships[12].institutions[0].country_code | DE |
| authorships[12].institutions[0].display_name | University of Tübingen |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Alexander N.R. Weber |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany; Institute of Immunology, Department of Innate Immunity, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), Partner Site Tübingen, a Partnership Between DKFZ and University Hospital Tübingen, Tübingen, Germany; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany. |
| authorships[13].author.id | https://openalex.org/A5020283727 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-4146-4664 |
| authorships[13].author.display_name | Victoria Klepsch |
| authorships[13].countries | AT |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I143397708, https://openalex.org/I190249584 |
| authorships[13].affiliations[0].raw_affiliation_string | Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria. |
| authorships[13].institutions[0].id | https://openalex.org/I143397708 |
| authorships[13].institutions[0].ror | https://ror.org/03pt86f80 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I143397708 |
| authorships[13].institutions[0].country_code | AT |
| authorships[13].institutions[0].display_name | Innsbruck Medical University |
| authorships[13].institutions[1].id | https://openalex.org/I190249584 |
| authorships[13].institutions[1].ror | https://ror.org/054pv6659 |
| authorships[13].institutions[1].type | education |
| authorships[13].institutions[1].lineage | https://openalex.org/I190249584 |
| authorships[13].institutions[1].country_code | AT |
| authorships[13].institutions[1].display_name | Universität Innsbruck |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Victoria Klepsch |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria. |
| authorships[14].author.id | https://openalex.org/A5039795688 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-3900-9227 |
| authorships[14].author.display_name | Kathy D. McCoy |
| authorships[14].countries | CA |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I168635309 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address: [email protected]. |
| authorships[14].institutions[0].id | https://openalex.org/I168635309 |
| authorships[14].institutions[0].ror | https://ror.org/03yjb2x39 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I168635309 |
| authorships[14].institutions[0].country_code | CA |
| authorships[14].institutions[0].display_name | University of Calgary |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Kathy D. McCoy |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address: [email protected]. |
| authorships[15].author.id | https://openalex.org/A5063318595 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-7426-2842 |
| authorships[15].author.display_name | Lukas F. Mager |
| authorships[15].countries | CA, DE |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I168635309, https://openalex.org/I8087733 |
| authorships[15].affiliations[0].raw_affiliation_string | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany; Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany. Electronic address: [email protected]. |
| authorships[15].institutions[0].id | https://openalex.org/I168635309 |
| authorships[15].institutions[0].ror | https://ror.org/03yjb2x39 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I168635309 |
| authorships[15].institutions[0].country_code | CA |
| authorships[15].institutions[0].display_name | University of Calgary |
| authorships[15].institutions[1].id | https://openalex.org/I8087733 |
| authorships[15].institutions[1].ror | https://ror.org/03a1kwz48 |
| authorships[15].institutions[1].type | education |
| authorships[15].institutions[1].lineage | https://openalex.org/I8087733 |
| authorships[15].institutions[1].country_code | DE |
| authorships[15].institutions[1].display_name | University of Tübingen |
| authorships[15].author_position | last |
| authorships[15].raw_author_name | Lukas F. Mager |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | M3 Research Center, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Department of Internal Medicine I, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany; Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; IFIT Cluster of Excellence EXC 2180 "Image Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany. Electronic address: [email protected]. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.celrep.2025.116223 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12996 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9990000128746033 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1305 |
| primary_topic.subfield.display_name | Biotechnology |
| primary_topic.display_name | Cancer Research and Treatments |
| related_works | https://openalex.org/W4240180367, https://openalex.org/W2357948923, https://openalex.org/W4313472242, https://openalex.org/W2332159055, https://openalex.org/W1832638316, https://openalex.org/W2030500189, https://openalex.org/W2084906504, https://openalex.org/W2419188526, https://openalex.org/W2144422987, https://openalex.org/W2018938924 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1016/j.celrep.2025.116223 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S169236886 |
| best_oa_location.source.issn | 2211-1247, 2639-1856 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2211-1247 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Cell Reports |
| best_oa_location.source.host_organization | https://openalex.org/P4310315673 |
| best_oa_location.source.host_organization_name | Cell Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310315673 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cell Reports |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.celrep.2025.116223 |
| primary_location.id | doi:10.1016/j.celrep.2025.116223 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S169236886 |
| primary_location.source.issn | 2211-1247, 2639-1856 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2211-1247 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Cell Reports |
| primary_location.source.host_organization | https://openalex.org/P4310315673 |
| primary_location.source.host_organization_name | Cell Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315673 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cell Reports |
| primary_location.landing_page_url | https://doi.org/10.1016/j.celrep.2025.116223 |
| publication_date | 2025-09-01 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4224865622, https://openalex.org/W3202401622, https://openalex.org/W4211199921, https://openalex.org/W4390058606, https://openalex.org/W2029904263, https://openalex.org/W1987390002, https://openalex.org/W2967681225, https://openalex.org/W1981600259, https://openalex.org/W2606228938, https://openalex.org/W2766903152, https://openalex.org/W2165456770, https://openalex.org/W2059128083, https://openalex.org/W2185075416, https://openalex.org/W4324044824, https://openalex.org/W2915010259, https://openalex.org/W2920009718, https://openalex.org/W4362664359, https://openalex.org/W4321480235, https://openalex.org/W3049052172, https://openalex.org/W3035535272, https://openalex.org/W4321601949, https://openalex.org/W4396664217, https://openalex.org/W2993201129, https://openalex.org/W2015760801, https://openalex.org/W1993121538, https://openalex.org/W2292980363, https://openalex.org/W3113227869, https://openalex.org/W4406472830, https://openalex.org/W2990988543, https://openalex.org/W4389899896, https://openalex.org/W2031643800, https://openalex.org/W3110484940, https://openalex.org/W2897131885, https://openalex.org/W4391741339, https://openalex.org/W4212790658, https://openalex.org/W3037239761, https://openalex.org/W3134658668, https://openalex.org/W2019010829, https://openalex.org/W2121385812, https://openalex.org/W4225329304, https://openalex.org/W4315782103 |
| referenced_works_count | 41 |
| abstract_inverted_index.2 | 121 |
| abstract_inverted_index.T | 67, 103 |
| abstract_inverted_index.a | 86 |
| abstract_inverted_index.We | 48 |
| abstract_inverted_index.an | 146 |
| abstract_inverted_index.as | 145 |
| abstract_inverted_index.by | 74, 82 |
| abstract_inverted_index.in | 85, 109, 123, 131, 149 |
| abstract_inverted_index.is | 27 |
| abstract_inverted_index.of | 22, 106 |
| abstract_inverted_index.or | 10, 43 |
| abstract_inverted_index.to | 9 |
| abstract_inverted_index.EPS | 64, 79, 114, 144 |
| abstract_inverted_index.Th1 | 66 |
| abstract_inverted_index.The | 20 |
| abstract_inverted_index.and | 34, 58, 93, 127 |
| abstract_inverted_index.can | 6 |
| abstract_inverted_index.for | 24, 102 |
| abstract_inverted_index.our | 140 |
| abstract_inverted_index.the | 14, 75 |
| abstract_inverted_index.two | 54 |
| abstract_inverted_index.use | 21 |
| abstract_inverted_index.was | 71, 80 |
| abstract_inverted_index.yet | 32 |
| abstract_inverted_index.Both | 98 |
| abstract_inverted_index.cell | 68, 129 |
| abstract_inverted_index.from | 53 |
| abstract_inverted_index.have | 49 |
| abstract_inverted_index.taxa | 5 |
| abstract_inverted_index.were | 100 |
| abstract_inverted_index.IL-12 | 116 |
| abstract_inverted_index.Thus, | 39 |
| abstract_inverted_index.While | 0 |
| abstract_inverted_index.cells | 84, 108, 126 |
| abstract_inverted_index.colon | 111, 133 |
| abstract_inverted_index.death | 130 |
| abstract_inverted_index.human | 124 |
| abstract_inverted_index.study | 141 |
| abstract_inverted_index.tumor | 94, 107 |
| abstract_inverted_index.under | 29 |
| abstract_inverted_index.which | 70, 89 |
| abstract_inverted_index.(EPSs) | 52 |
| abstract_inverted_index.(TLR2) | 122 |
| abstract_inverted_index.cancer | 12, 112, 134 |
| abstract_inverted_index.cells. | 138 |
| abstract_inverted_index.factor | 96 |
| abstract_inverted_index.immune | 137 |
| abstract_inverted_index.murine | 110 |
| abstract_inverted_index.poorly | 18 |
| abstract_inverted_index.remain | 17, 37 |
| abstract_inverted_index.safety | 33 |
| abstract_inverted_index.sensed | 81 |
| abstract_inverted_index.(IL)-12 | 92 |
| abstract_inverted_index.boosted | 73 |
| abstract_inverted_index.cancer. | 150 |
| abstract_inverted_index.further | 72 |
| abstract_inverted_index.hurdles | 36 |
| abstract_inverted_index.improve | 11 |
| abstract_inverted_index.induced | 90 |
| abstract_inverted_index.intense | 30 |
| abstract_inverted_index.killing | 105 |
| abstract_inverted_index.manner, | 88 |
| abstract_inverted_index.models. | 113 |
| abstract_inverted_index.predict | 7 |
| abstract_inverted_index.promote | 61 |
| abstract_inverted_index.provide | 45 |
| abstract_inverted_index.several | 1 |
| abstract_inverted_index.through | 118, 136 |
| abstract_inverted_index.adjuvant | 147 |
| abstract_inverted_index.distinct | 3 |
| abstract_inverted_index.extracts | 44 |
| abstract_inverted_index.improved | 65 |
| abstract_inverted_index.inosine. | 77 |
| abstract_inverted_index.microbes | 23 |
| abstract_inverted_index.necrosis | 95 |
| abstract_inverted_index.promoted | 128 |
| abstract_inverted_index.receptor | 120 |
| abstract_inverted_index.required | 101 |
| abstract_inverted_index.(TNF)-α. | 97 |
| abstract_inverted_index.Toll-like | 119 |
| abstract_inverted_index.bacterial | 4, 55 |
| abstract_inverted_index.currently | 28 |
| abstract_inverted_index.cytokines | 99 |
| abstract_inverted_index.dendritic | 83, 125 |
| abstract_inverted_index.immunity, | 69 |
| abstract_inverted_index.immunity. | 63 |
| abstract_inverted_index.microbial | 25 |
| abstract_inverted_index.molecules | 42 |
| abstract_inverted_index.organoids | 135 |
| abstract_inverted_index.promising | 46 |
| abstract_inverted_index.research, | 31 |
| abstract_inverted_index.responses | 8 |
| abstract_inverted_index.anti-tumor | 62 |
| abstract_inverted_index.identified | 50 |
| abstract_inverted_index.identifies | 142 |
| abstract_inverted_index.mechanisms | 16 |
| abstract_inverted_index.metabolite | 76 |
| abstract_inverted_index.production | 117 |
| abstract_inverted_index.regulatory | 35 |
| abstract_inverted_index.stimulated | 115 |
| abstract_inverted_index.underlying | 15 |
| abstract_inverted_index.interleukin | 91 |
| abstract_inverted_index.understood. | 19 |
| abstract_inverted_index.challenging. | 38 |
| abstract_inverted_index.pseudolongum | 57 |
| abstract_inverted_index.therapeutics | 26 |
| abstract_inverted_index.Collectively, | 139 |
| abstract_inverted_index.alternatives. | 47 |
| abstract_inverted_index.immunotherapy | 148 |
| abstract_inverted_index.cell-dependent | 104 |
| abstract_inverted_index.Bifidobacterium | 59 |
| abstract_inverted_index.microbe-derived | 143 |
| abstract_inverted_index.non-replicative | 40 |
| abstract_inverted_index.patient-derived | 132 |
| abstract_inverted_index.Mechanistically, | 78 |
| abstract_inverted_index.immunotherapies, | 13 |
| abstract_inverted_index.phylogenetically | 2 |
| abstract_inverted_index.bacterial-derived | 41 |
| abstract_inverted_index.exopolysaccharides | 51 |
| abstract_inverted_index.Tlr2-MyD88-dependent | 87 |
| abstract_inverted_index.pseudocatenulatum-that | 60 |
| abstract_inverted_index.species-Bifidobacterium | 56 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 16 |
| citation_normalized_percentile.value | 0.90695033 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |