Human Brain Mapping • Vol 46 • No 9
Big Data, Small Bias: Harmonizing Diffusion <scp>MRI</scp> ‐Based Structural Connectomes to Mitigate Site‐Related Bias in Data Integration
June 2025 • Rui Sherry Shen, Drew Parker, Andrew A. Chen, Benjamin E. Yerys, Birkan Tunç, Timothy P. L. Roberts, Russell T. Shinohara, Ragini Verma
ABSTRACT Diffusion MRI‐based structural connectomes are increasingly used to investigate brain connectivity changes associated with various disorders. However, small sample sizes in individual studies, along with highly heterogeneous disorder‐related manifestations, underscore the need to pool datasets across multiple studies to be able to identify coherent and generalizable connectivity patterns linked to these disorders. Yet, combining datasets introduces site‐related differences due to variations in scanner har…