Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks Article Swipe
Abdou Akkouche
,
Emma Kneuss
,
Susanne Bornelöv
,
Yoan Renaud
,
Evelyn L. Eastwood
,
Jasper van Lopik
,
Nathalie Gueguen
,
Mingxuan Jiang
,
Pau Creixell
,
Stéphanie Maupetit‐Mehouas
,
Anna Sobieszek
,
Yifan Gui
,
Benjamin Czech Nicholson
,
Émilie Brasset
,
Gregory J. Hannon
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41594-025-01584-8
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41594-025-01584-8
Animal germ cells deploy a specialized small RNA-based silencing system, called the PIWI-interacting RNA (piRNA) pathway, to prevent unwanted expression of transposable elements (TEs) and maintain genome integrity. In Drosophila melanogaster germ cells, the majority of piRNA populations originate from dual-strand piRNA clusters, genomic regions highly enriched in TE fragments, via an elaborate machinery centered on the Heterochromatin Protein 1 homolog, Rhino. Although Rhino binds to peptides carrying tri-methylated H3K9 in vitro, it is not fully understood why in vivo only a fraction of H3K9me3-decorated heterochromatin is occupied by Rhino. Recent work revealed that Rhino is recruited to a subset of piRNA clusters by Kipferl. Here we identify a Kipferl-independent mode of Rhino recruitment that, in addition to the previously established role of H3K9me3, also depends on the histone H3 lysine 27 methyltransferase Enhancer of Zeste. At Kipferl-independent sites, we find that Rhino specifically binds to loci marked by both H3K9me3 and H3K27me3 via its chromodomain. Although the exact mechanism of how Rhino binding is influenced by dual histone modifications remains unclear from a structural and biochemical perspective, our work suggests that combinatorial modifications may regulate the specificity of chromatin-binding protein interactions. These findings provide an enhanced understanding of how Rhino targets piRNA source loci, highlighting the sophisticated epigenetic landscape governing TE silencing in Drosophila germ cells.
Related Topics
Concepts
Piwi-interacting RNA
Chromodomain
Biology
Heterochromatin protein 1
Heterochromatin
Chromatin
Genetics
Histone
Epigenetics
Drosophila melanogaster
Enhancer
Argonaute
Cell biology
Transposable element
RNA
Genome
RNA interference
Gene expression
Gene
Helicase
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41594-025-01584-8
- https://www.nature.com/articles/s41594-025-01584-8.pdf
- OA Status
- hybrid
- Cited By
- 2
- References
- 84
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411382232
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4411382232Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41594-025-01584-8Digital Object Identifier
- Title
-
Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marksWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-17Full publication date if available
- Authors
-
Abdou Akkouche, Emma Kneuss, Susanne Bornelöv, Yoan Renaud, Evelyn L. Eastwood, Jasper van Lopik, Nathalie Gueguen, Mingxuan Jiang, Pau Creixell, Stéphanie Maupetit‐Mehouas, Anna Sobieszek, Yifan Gui, Benjamin Czech Nicholson, Émilie Brasset, Gregory J. HannonList of authors in order
- Landing page
-
https://doi.org/10.1038/s41594-025-01584-8Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41594-025-01584-8.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41594-025-01584-8.pdfDirect OA link when available
- Concepts
-
Piwi-interacting RNA, Chromodomain, Biology, Heterochromatin protein 1, Heterochromatin, Chromatin, Genetics, Histone, Epigenetics, Drosophila melanogaster, Enhancer, Argonaute, Cell biology, Transposable element, RNA, Genome, RNA interference, Gene expression, Gene, HelicaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
84Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| institutions_distinct_count | 15 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.6299999952316284 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.95785131 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |