Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9 Article Swipe
Jinjun Wu
,
Hanyong Peng
,
Xiufen Lu
,
Maode Lai
,
Hongquan Zhang
,
X. Chris Le
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/ange.202014162
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/ange.202014162
Protein coronae formed with nanoparticles confer several useful properties. However, the non‐specific nature of protein corona formation makes it difficult to deliver specific proteins for therapeutic applications. Herein, we report on the construction of a new type of protein corona, termed binding‐mediated protein corona. This new corona enables the efficient and controllable delivery of functional proteins, which is otherwise challenging for conventional protein coronae. We show the design and delivery of the ribonucleoprotein corona for the CRISPR/Cas9 system. Successful gene editing in human cell lines (Hela and HEK293) demonstrates the efficient delivery, high stability, low cytotoxicity, and well‐controlled activity of the Cas9‐guide RNA ribonucleoprotein. The binding‐mediated protein corona strategy opens up new opportunities for therapeutic protein delivery.
Related Topics
Concepts
Ribonucleoprotein
CRISPR
Cas9
HeLa
Corona (planetary geology)
Chemistry
HEK 293 cells
Cell biology
Gene delivery
RNA
Computational biology
Biophysics
Nanotechnology
Cell
Gene
Biology
Genetic enhancement
Biochemistry
Materials science
Venus
Astrobiology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/ange.202014162
- OA Status
- hybrid
- Cited By
- 3
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4233109317
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4233109317Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/ange.202014162Digital Object Identifier
- Title
-
Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-24Full publication date if available
- Authors
-
Jinjun Wu, Hanyong Peng, Xiufen Lu, Maode Lai, Hongquan Zhang, X. Chris LeList of authors in order
- Landing page
-
https://doi.org/10.1002/ange.202014162Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1002/ange.202014162Direct OA link when available
- Concepts
-
Ribonucleoprotein, CRISPR, Cas9, HeLa, Corona (planetary geology), Chemistry, HEK 293 cells, Cell biology, Gene delivery, RNA, Computational biology, Biophysics, Nanotechnology, Cell, Gene, Biology, Genetic enhancement, Biochemistry, Materials science, Venus, AstrobiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4233109317 |
|---|---|
| doi | https://doi.org/10.1002/ange.202014162 |
| ids.doi | https://doi.org/10.1002/ange.202014162 |
| ids.openalex | https://openalex.org/W4233109317 |
| fwci | 0.0 |
| type | article |
| title | Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9 |
| biblio.issue | 20 |
| biblio.volume | 133 |
| biblio.last_page | 11209 |
| biblio.first_page | 11204 |
| grants[0].funder | https://openalex.org/F4320314105 |
| grants[0].award_id | |
| grants[0].funder_display_name | Government of Alberta |
| grants[1].funder | https://openalex.org/F4320320994 |
| grants[1].award_id | |
| grants[1].funder_display_name | Canada Research Chairs |
| grants[2].funder | https://openalex.org/F4320325651 |
| grants[2].award_id | |
| grants[2].funder_display_name | Alberta Innovates |
| grants[3].funder | https://openalex.org/F4320334506 |
| grants[3].award_id | |
| grants[3].funder_display_name | Canadian Institutes of Health Research |
| grants[4].funder | https://openalex.org/F4320334593 |
| grants[4].award_id | |
| grants[4].funder_display_name | Natural Sciences and Engineering Research Council of Canada |
| topics[0].id | https://openalex.org/T10725 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | RNA Interference and Gene Delivery |
| topics[1].id | https://openalex.org/T10207 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9995999932289124 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Advanced biosensing and bioanalysis techniques |
| topics[2].id | https://openalex.org/T10063 |
| topics[2].field.id | https://openalex.org/fields/25 |
| topics[2].field.display_name | Materials Science |
| topics[2].score | 0.9939000010490417 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2502 |
| topics[2].subfield.display_name | Biomaterials |
| topics[2].display_name | Nanoparticle-Based Drug Delivery |
| funders[0].id | https://openalex.org/F4320314105 |
| funders[0].ror | https://ror.org/006b2g567 |
| funders[0].display_name | Government of Alberta |
| funders[1].id | https://openalex.org/F4320320994 |
| funders[1].ror | https://ror.org/0517h6h17 |
| funders[1].display_name | Canada Research Chairs |
| funders[2].id | https://openalex.org/F4320325651 |
| funders[2].ror | |
| funders[2].display_name | Alberta Innovates |
| funders[3].id | https://openalex.org/F4320334506 |
| funders[3].ror | https://ror.org/01gavpb45 |
| funders[3].display_name | Canadian Institutes of Health Research |
| funders[4].id | https://openalex.org/F4320334593 |
| funders[4].ror | https://ror.org/01h531d29 |
| funders[4].display_name | Natural Sciences and Engineering Research Council of Canada |
| is_xpac | False |
| apc_list.value | 5250 |
| apc_list.currency | USD |
| apc_list.value_usd | 5250 |
| apc_paid.value | 5250 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 5250 |
| concepts[0].id | https://openalex.org/C75934600 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8674247860908508 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q419245 |
| concepts[0].display_name | Ribonucleoprotein |
| concepts[1].id | https://openalex.org/C98108389 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7918908596038818 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q412563 |
| concepts[1].display_name | CRISPR |
| concepts[2].id | https://openalex.org/C132455925 |
| concepts[2].level | 4 |
| concepts[2].score | 0.7359471321105957 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q16965677 |
| concepts[2].display_name | Cas9 |
| concepts[3].id | https://openalex.org/C2777366897 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6070238351821899 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q847482 |
| concepts[3].display_name | HeLa |
| concepts[4].id | https://openalex.org/C2776779350 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5445024371147156 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1134503 |
| concepts[4].display_name | Corona (planetary geology) |
| concepts[5].id | https://openalex.org/C185592680 |
| concepts[5].level | 0 |
| concepts[5].score | 0.5242878794670105 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[5].display_name | Chemistry |
| concepts[6].id | https://openalex.org/C174510640 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4981374740600586 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q489618 |
| concepts[6].display_name | HEK 293 cells |
| concepts[7].id | https://openalex.org/C95444343 |
| concepts[7].level | 1 |
| concepts[7].score | 0.47276952862739563 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[7].display_name | Cell biology |
| concepts[8].id | https://openalex.org/C135983454 |
| concepts[8].level | 4 |
| concepts[8].score | 0.44854727387428284 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q2790163 |
| concepts[8].display_name | Gene delivery |
| concepts[9].id | https://openalex.org/C67705224 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4336891174316406 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11053 |
| concepts[9].display_name | RNA |
| concepts[10].id | https://openalex.org/C70721500 |
| concepts[10].level | 1 |
| concepts[10].score | 0.40469008684158325 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[10].display_name | Computational biology |
| concepts[11].id | https://openalex.org/C12554922 |
| concepts[11].level | 1 |
| concepts[11].score | 0.4016062319278717 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7100 |
| concepts[11].display_name | Biophysics |
| concepts[12].id | https://openalex.org/C171250308 |
| concepts[12].level | 1 |
| concepts[12].score | 0.37678930163383484 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11468 |
| concepts[12].display_name | Nanotechnology |
| concepts[13].id | https://openalex.org/C1491633281 |
| concepts[13].level | 2 |
| concepts[13].score | 0.29863816499710083 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7868 |
| concepts[13].display_name | Cell |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.27883270382881165 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| concepts[15].id | https://openalex.org/C86803240 |
| concepts[15].level | 0 |
| concepts[15].score | 0.2785792648792267 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[15].display_name | Biology |
| concepts[16].id | https://openalex.org/C111599444 |
| concepts[16].level | 3 |
| concepts[16].score | 0.20192033052444458 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q213901 |
| concepts[16].display_name | Genetic enhancement |
| concepts[17].id | https://openalex.org/C55493867 |
| concepts[17].level | 1 |
| concepts[17].score | 0.174536794424057 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[17].display_name | Biochemistry |
| concepts[18].id | https://openalex.org/C192562407 |
| concepts[18].level | 0 |
| concepts[18].score | 0.12221217155456543 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[18].display_name | Materials science |
| concepts[19].id | https://openalex.org/C2779900269 |
| concepts[19].level | 2 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q1408724 |
| concepts[19].display_name | Venus |
| concepts[20].id | https://openalex.org/C87355193 |
| concepts[20].level | 1 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q411 |
| concepts[20].display_name | Astrobiology |
| keywords[0].id | https://openalex.org/keywords/ribonucleoprotein |
| keywords[0].score | 0.8674247860908508 |
| keywords[0].display_name | Ribonucleoprotein |
| keywords[1].id | https://openalex.org/keywords/crispr |
| keywords[1].score | 0.7918908596038818 |
| keywords[1].display_name | CRISPR |
| keywords[2].id | https://openalex.org/keywords/cas9 |
| keywords[2].score | 0.7359471321105957 |
| keywords[2].display_name | Cas9 |
| keywords[3].id | https://openalex.org/keywords/hela |
| keywords[3].score | 0.6070238351821899 |
| keywords[3].display_name | HeLa |
| keywords[4].id | https://openalex.org/keywords/corona |
| keywords[4].score | 0.5445024371147156 |
| keywords[4].display_name | Corona (planetary geology) |
| keywords[5].id | https://openalex.org/keywords/chemistry |
| keywords[5].score | 0.5242878794670105 |
| keywords[5].display_name | Chemistry |
| keywords[6].id | https://openalex.org/keywords/hek-293-cells |
| keywords[6].score | 0.4981374740600586 |
| keywords[6].display_name | HEK 293 cells |
| keywords[7].id | https://openalex.org/keywords/cell-biology |
| keywords[7].score | 0.47276952862739563 |
| keywords[7].display_name | Cell biology |
| keywords[8].id | https://openalex.org/keywords/gene-delivery |
| keywords[8].score | 0.44854727387428284 |
| keywords[8].display_name | Gene delivery |
| keywords[9].id | https://openalex.org/keywords/rna |
| keywords[9].score | 0.4336891174316406 |
| keywords[9].display_name | RNA |
| keywords[10].id | https://openalex.org/keywords/computational-biology |
| keywords[10].score | 0.40469008684158325 |
| keywords[10].display_name | Computational biology |
| keywords[11].id | https://openalex.org/keywords/biophysics |
| keywords[11].score | 0.4016062319278717 |
| keywords[11].display_name | Biophysics |
| keywords[12].id | https://openalex.org/keywords/nanotechnology |
| keywords[12].score | 0.37678930163383484 |
| keywords[12].display_name | Nanotechnology |
| keywords[13].id | https://openalex.org/keywords/cell |
| keywords[13].score | 0.29863816499710083 |
| keywords[13].display_name | Cell |
| keywords[14].id | https://openalex.org/keywords/gene |
| keywords[14].score | 0.27883270382881165 |
| keywords[14].display_name | Gene |
| keywords[15].id | https://openalex.org/keywords/biology |
| keywords[15].score | 0.2785792648792267 |
| keywords[15].display_name | Biology |
| keywords[16].id | https://openalex.org/keywords/genetic-enhancement |
| keywords[16].score | 0.20192033052444458 |
| keywords[16].display_name | Genetic enhancement |
| keywords[17].id | https://openalex.org/keywords/biochemistry |
| keywords[17].score | 0.174536794424057 |
| keywords[17].display_name | Biochemistry |
| keywords[18].id | https://openalex.org/keywords/materials-science |
| keywords[18].score | 0.12221217155456543 |
| keywords[18].display_name | Materials science |
| language | en |
| locations[0].id | doi:10.1002/ange.202014162 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210200754 |
| locations[0].source.issn | 0044-8249, 1521-3757 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0044-8249 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Angewandte Chemie |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Angewandte Chemie |
| locations[0].landing_page_url | https://doi.org/10.1002/ange.202014162 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5016379696 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2379-1162 |
| authorships[0].author.display_name | Jinjun Wu |
| authorships[0].countries | CA |
| authorships[0].affiliations[0].raw_affiliation_string | These authors contributed equally to this work. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I154425047 |
| authorships[0].affiliations[1].raw_affiliation_string | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada |
| authorships[0].institutions[0].id | https://openalex.org/I154425047 |
| authorships[0].institutions[0].ror | https://ror.org/0160cpw27 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I154425047 |
| authorships[0].institutions[0].country_code | CA |
| authorships[0].institutions[0].display_name | University of Alberta |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jinjun Wu |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada, These authors contributed equally to this work. |
| authorships[1].author.id | https://openalex.org/A5071428253 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-7079-0827 |
| authorships[1].author.display_name | Hanyong Peng |
| authorships[1].countries | CA |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I154425047 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada |
| authorships[1].affiliations[1].raw_affiliation_string | These authors contributed equally to this work. |
| authorships[1].institutions[0].id | https://openalex.org/I154425047 |
| authorships[1].institutions[0].ror | https://ror.org/0160cpw27 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I154425047 |
| authorships[1].institutions[0].country_code | CA |
| authorships[1].institutions[0].display_name | University of Alberta |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Hanyong Peng |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada, These authors contributed equally to this work. |
| authorships[2].author.id | https://openalex.org/A5103096345 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6954-5143 |
| authorships[2].author.display_name | Xiufen Lu |
| authorships[2].countries | CA |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I154425047 |
| authorships[2].affiliations[0].raw_affiliation_string | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada |
| authorships[2].institutions[0].id | https://openalex.org/I154425047 |
| authorships[2].institutions[0].ror | https://ror.org/0160cpw27 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I154425047 |
| authorships[2].institutions[0].country_code | CA |
| authorships[2].institutions[0].display_name | University of Alberta |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Xiufen Lu |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada |
| authorships[3].author.id | https://openalex.org/A5040198181 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-4636-0223 |
| authorships[3].author.display_name | Maode Lai |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I76130692 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058 China |
| authorships[3].institutions[0].id | https://openalex.org/I76130692 |
| authorships[3].institutions[0].ror | https://ror.org/00a2xv884 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I76130692 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Zhejiang University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Maode Lai |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058 China |
| authorships[4].author.id | https://openalex.org/A5100707241 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-1088-9862 |
| authorships[4].author.display_name | Hongquan Zhang |
| authorships[4].countries | CA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I154425047 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada |
| authorships[4].institutions[0].id | https://openalex.org/I154425047 |
| authorships[4].institutions[0].ror | https://ror.org/0160cpw27 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I154425047 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | University of Alberta |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Hongquan Zhang |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada |
| authorships[5].author.id | https://openalex.org/A5039488721 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-7690-6701 |
| authorships[5].author.display_name | X. Chris Le |
| authorships[5].countries | CA |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I154425047 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada |
| authorships[5].institutions[0].id | https://openalex.org/I154425047 |
| authorships[5].institutions[0].ror | https://ror.org/0160cpw27 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I154425047 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | University of Alberta |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | X. Chris Le |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1002/ange.202014162 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9 |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10725 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | RNA Interference and Gene Delivery |
| related_works | https://openalex.org/W2581151188, https://openalex.org/W2942622860, https://openalex.org/W4297201610, https://openalex.org/W4229853727, https://openalex.org/W2999105079, https://openalex.org/W4200108880, https://openalex.org/W2908238701, https://openalex.org/W4200063435, https://openalex.org/W4255082801, https://openalex.org/W2562768587 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1002/ange.202014162 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210200754 |
| best_oa_location.source.issn | 0044-8249, 1521-3757 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0044-8249 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Angewandte Chemie |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Angewandte Chemie |
| best_oa_location.landing_page_url | https://doi.org/10.1002/ange.202014162 |
| primary_location.id | doi:10.1002/ange.202014162 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210200754 |
| primary_location.source.issn | 0044-8249, 1521-3757 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0044-8249 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Angewandte Chemie |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Angewandte Chemie |
| primary_location.landing_page_url | https://doi.org/10.1002/ange.202014162 |
| publication_date | 2020-12-24 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2057910069, https://openalex.org/W2773580742, https://openalex.org/W2605342716, https://openalex.org/W2110634891, https://openalex.org/W2158558808, https://openalex.org/W2157016784, https://openalex.org/W2019637120, https://openalex.org/W2006165138, https://openalex.org/W2757272801, https://openalex.org/W2898317973, https://openalex.org/W2807815519, https://openalex.org/W1973831032, https://openalex.org/W1990796256, https://openalex.org/W2334316877, https://openalex.org/W1996396874, https://openalex.org/W2553731867, https://openalex.org/W2321389840, https://openalex.org/W1966172363, https://openalex.org/W2332055943, https://openalex.org/W3083833107, https://openalex.org/W2125123295, https://openalex.org/W2067769271, https://openalex.org/W2788997515, https://openalex.org/W2073217307, https://openalex.org/W2947834670, https://openalex.org/W2759402071, https://openalex.org/W2581151188, https://openalex.org/W2810249184, https://openalex.org/W2779247349, https://openalex.org/W4229872765, https://openalex.org/W2088793182, https://openalex.org/W2589818318, https://openalex.org/W2995940501, https://openalex.org/W2971097067, https://openalex.org/W1981923877, https://openalex.org/W2790949710, https://openalex.org/W1987911559, https://openalex.org/W2064715286, https://openalex.org/W2511233179, https://openalex.org/W4251173290, https://openalex.org/W2919028532, https://openalex.org/W4247623237, https://openalex.org/W3045621348, https://openalex.org/W4229646087, https://openalex.org/W3011610702, https://openalex.org/W4230021594, https://openalex.org/W1989353246, https://openalex.org/W2021538200, https://openalex.org/W1994357966, https://openalex.org/W2974386912, https://openalex.org/W2755806464, https://openalex.org/W2089974427 |
| referenced_works_count | 52 |
| abstract_inverted_index.a | 35 |
| abstract_inverted_index.We | 65 |
| abstract_inverted_index.in | 82 |
| abstract_inverted_index.is | 58 |
| abstract_inverted_index.it | 19 |
| abstract_inverted_index.of | 14, 34, 38, 54, 71, 100 |
| abstract_inverted_index.on | 31 |
| abstract_inverted_index.to | 21 |
| abstract_inverted_index.up | 111 |
| abstract_inverted_index.we | 29 |
| abstract_inverted_index.RNA | 103 |
| abstract_inverted_index.The | 105 |
| abstract_inverted_index.and | 51, 69, 87, 97 |
| abstract_inverted_index.for | 25, 61, 75, 114 |
| abstract_inverted_index.low | 95 |
| abstract_inverted_index.new | 36, 46, 112 |
| abstract_inverted_index.the | 11, 32, 49, 67, 72, 76, 90, 101 |
| abstract_inverted_index.This | 45 |
| abstract_inverted_index.cell | 84 |
| abstract_inverted_index.gene | 80 |
| abstract_inverted_index.high | 93 |
| abstract_inverted_index.show | 66 |
| abstract_inverted_index.type | 37 |
| abstract_inverted_index.with | 4 |
| abstract_inverted_index.(Hela | 86 |
| abstract_inverted_index.human | 83 |
| abstract_inverted_index.lines | 85 |
| abstract_inverted_index.makes | 18 |
| abstract_inverted_index.opens | 110 |
| abstract_inverted_index.which | 57 |
| abstract_inverted_index.confer | 6 |
| abstract_inverted_index.corona | 16, 47, 74, 108 |
| abstract_inverted_index.design | 68 |
| abstract_inverted_index.formed | 3 |
| abstract_inverted_index.nature | 13 |
| abstract_inverted_index.report | 30 |
| abstract_inverted_index.termed | 41 |
| abstract_inverted_index.useful | 8 |
| abstract_inverted_index.HEK293) | 88 |
| abstract_inverted_index.Herein, | 28 |
| abstract_inverted_index.Protein | 1 |
| abstract_inverted_index.corona, | 40 |
| abstract_inverted_index.corona. | 44 |
| abstract_inverted_index.coronae | 2 |
| abstract_inverted_index.deliver | 22 |
| abstract_inverted_index.editing | 81 |
| abstract_inverted_index.enables | 48 |
| abstract_inverted_index.protein | 15, 39, 43, 63, 107, 116 |
| abstract_inverted_index.several | 7 |
| abstract_inverted_index.system. | 78 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 10 |
| abstract_inverted_index.activity | 99 |
| abstract_inverted_index.coronae. | 64 |
| abstract_inverted_index.delivery | 53, 70 |
| abstract_inverted_index.proteins | 24 |
| abstract_inverted_index.specific | 23 |
| abstract_inverted_index.strategy | 109 |
| abstract_inverted_index.delivery, | 92 |
| abstract_inverted_index.delivery. | 117 |
| abstract_inverted_index.difficult | 20 |
| abstract_inverted_index.efficient | 50, 91 |
| abstract_inverted_index.formation | 17 |
| abstract_inverted_index.otherwise | 59 |
| abstract_inverted_index.proteins, | 56 |
| abstract_inverted_index.Successful | 79 |
| abstract_inverted_index.functional | 55 |
| abstract_inverted_index.stability, | 94 |
| abstract_inverted_index.CRISPR/Cas9 | 77 |
| abstract_inverted_index.challenging | 60 |
| abstract_inverted_index.properties. | 9 |
| abstract_inverted_index.therapeutic | 26, 115 |
| abstract_inverted_index.Cas9‐guide | 102 |
| abstract_inverted_index.construction | 33 |
| abstract_inverted_index.controllable | 52 |
| abstract_inverted_index.conventional | 62 |
| abstract_inverted_index.demonstrates | 89 |
| abstract_inverted_index.applications. | 27 |
| abstract_inverted_index.cytotoxicity, | 96 |
| abstract_inverted_index.nanoparticles | 5 |
| abstract_inverted_index.opportunities | 113 |
| abstract_inverted_index.non‐specific | 12 |
| abstract_inverted_index.ribonucleoprotein | 73 |
| abstract_inverted_index.well‐controlled | 98 |
| abstract_inverted_index.binding‐mediated | 42, 106 |
| abstract_inverted_index.ribonucleoprotein. | 104 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5100707241, https://openalex.org/A5039488721 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I154425047 |
| citation_normalized_percentile.value | 0.18239448 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |