Bioactivity Assessment and Untargeted Metabolomics of the Mediterranean Sea Pen Pennatula phosphorea Article Swipe
Silvia Scarpato
,
Daniel Venturi
,
Fortunato Palma Esposito
,
Maria Cristina Mangano
,
Gianluca Sarà
,
Francesco Margiotta
,
Ester Pagano
,
María Cruz Miraglia
,
Enrico Sangiovanni
,
Mercedes Garcia‐Gil
,
Lorenzo Di Cesare Mannelli
,
Carla Ghelardini
,
Mario Dell’Agli
,
Angelo A. Izzo
,
Paola Nieri
,
Donatella de Pascale
,
Gerardo Della Sala
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/md23050218
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/md23050218
Octocorals have proven to be a prolific source of bioactive natural products, exhibiting a wide spectrum of pharmacological activities. Among octocorals, Pennatulaceans, commonly known as sea pens, are among the most dominant soft coral species living in benthic communities. Nonetheless, reports on bioactivity and chemical investigations of this genus are scarce. This prompted us to shed light on the pharmacological potential of the extracts of the sea pen Pennatula phosphorea, Linneus 1758, and gain an overview of its metabolome. Crude octocoral extracts, obtained with a modified Kupchan extraction protocol, were assessed for their bioactivity potential, revealing the hexanic extract to exert anti-inflammatory effects and interesting protective properties in an in vitro model of sarcopenia and in auditory HEI-OC1 cisplatin-treated cells, while the chloroformic extract was active in reducing A375 melanoma cell viability in a concentration-dependent manner. An untargeted metabolomic analysis unveiled that P. phosphorea collects a wide array of glycerophospholipids and phosphosphingolipids belonging to the ceramide phosphoinositol class, which were exclusive or more abundant in the hexanic extract. Their proven anti-inflammatory and cytoprotective effects could demonstrate the activity shown by the P. phosphorea hexanic extract. In addition, a group of prostaglandins, eluted mainly in the chloroformic extract, were putatively annotated. Since prostanoids from marine origin have been demonstrated to exert cytotoxic and anti-proliferative properties against various cancer cell lines, the presence of PGs in the P. phosphorea chloroform extract could justify its anti-melanoma activity. This is the first report on the presence of glycerophospholipids, phosphosphingolipids, and prostaglandins, along with the identification of novel congeners, in sea pens.
Related Topics
Concepts
Biology
Metabolome
Glycerophospholipids
Phytochemical
Metabolomics
Traditional medicine
Biochemistry
Bioinformatics
Medicine
Phospholipid
Membrane
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/md23050218
- https://www.mdpi.com/1660-3397/23/5/218/pdf?version=1747826969
- OA Status
- gold
- Cited By
- 1
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410564351
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410564351Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/md23050218Digital Object Identifier
- Title
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Bioactivity Assessment and Untargeted Metabolomics of the Mediterranean Sea Pen Pennatula phosphoreaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-05-21Full publication date if available
- Authors
-
Silvia Scarpato, Daniel Venturi, Fortunato Palma Esposito, Maria Cristina Mangano, Gianluca Sarà, Francesco Margiotta, Ester Pagano, María Cruz Miraglia, Enrico Sangiovanni, Mercedes Garcia‐Gil, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Mario Dell’Agli, Angelo A. Izzo, Paola Nieri, Donatella de Pascale, Gerardo Della SalaList of authors in order
- Landing page
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https://doi.org/10.3390/md23050218Publisher landing page
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https://www.mdpi.com/1660-3397/23/5/218/pdf?version=1747826969Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1660-3397/23/5/218/pdf?version=1747826969Direct OA link when available
- Concepts
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Biology, Metabolome, Glycerophospholipids, Phytochemical, Metabolomics, Traditional medicine, Biochemistry, Bioinformatics, Medicine, Phospholipid, MembraneTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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92Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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