Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana , Plasmodium falciparum , and Trypanosoma cruzi Article Swipe
Carolina Proaño‐Bolaños
,
Giovanna Morán-Marcillo
,
Nina Espinosa de los Monteros‐Silva
,
Sebastián Bermúdez-Puga
,
Mateo Alejandro Salazar
,
Ailín Blasco-Zúñiga
,
Sebastián A. Cuesta
,
Carolina Molina
,
Franklin Espinosa
,
Lorena Meneses
,
Patricio Rojas‐Silva
,
Sonia Zapata
,
Fabián E. Saénz
,
Miryan Rivera I.
,
Jaime A. Costales
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.03339-23
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.03339-23
Chagas disease, leishmaniasis, and malaria are major parasitic diseases disproportionately affecting the underprivileged population in developing nations. Finding new, alternative anti-parasitic compounds to treat these diseases is crucial because of the limited number of options currently available, the side effects they cause, the need for long treatment courses, and the emergence of drug-resistant parasites. Anti-microbial peptides (AMPs) derived from amphibian skin secretions are small bioactive molecules capable of lysing the cell membrane of pathogens while having low toxicity against human cells. Here, we report the anti-parasitic activity of five AMPs derived from skin secretions of three Ecuadorian frogs: cruzioseptin-1, cruzioseptin-4 (CZS-4), and cruzioseptin-16 from Cruziohyla calcarifer ; dermaseptin-SP2 from Agalychnis spurrelli ; and pictuseptin-1 from Boana picturata . These five AMPs were chemically synthesized. Initially, the hemolytic activity of CZS-4 and its minimal inhibitory concentration against Escherichia coli , Staphylococcus aureus , and Candida albicans were determined. Subsequently, the cytotoxicity of the synthetic AMPs against mammalian cells and their anti-parasitic activity against Leishmania mexicana promastigotes, erythrocytic stages of Plasmodium falciparum and mammalian stages of Trypanosoma cruzi were evaluated in vitro . The five AMPs displayed activity against the pathogens studied, with different levels of cytotoxicity against mammalian cells. In silico molecular docking analysis suggests this bioactivity may occur via pore formation in the plasma membrane, resulting in microbial lysis. CZS-4 displayed anti-bacterial, anti-fungal, and anti-parasitic activities with low cytotoxicity against mammalian cells. Further studies about this promising AMP are required to gain a better understanding of its activity. IMPORTANCE Chagas disease, malaria, and leishmaniasis are major tropical diseases that cause extensive morbidity and mortality, for which available treatment options are unsatisfactory because of limited efficacy and side effects. Frog skin secretions contain molecules with anti-microbial properties known as anti-microbial peptides. We synthesized five peptides derived from the skin secretions of different species of tropical frogs and tested them against cultures of the causative agents of these three diseases, parasites known as Trypanosoma cruzi , Plasmodium falciparum , and Leishmania mexicana . All the different synthetic peptides studied showed activity against one of more of the parasites. Peptide cruzioseptin-4 is of special interest since it displayed intense activity against parasites while being innocuous against cultured mammalian cells, which indicates it does not simply hold general toxic properties; rather, its activity is specific against the parasites.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/spectrum.03339-23
- OA Status
- gold
- Cited By
- 5
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400686116
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4400686116Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/spectrum.03339-23Digital Object Identifier
- Title
-
Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana , Plasmodium falciparum , and Trypanosoma cruziWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-07-16Full publication date if available
- Authors
-
Carolina Proaño‐Bolaños, Giovanna Morán-Marcillo, Nina Espinosa de los Monteros‐Silva, Sebastián Bermúdez-Puga, Mateo Alejandro Salazar, Ailín Blasco-Zúñiga, Sebastián A. Cuesta, Carolina Molina, Franklin Espinosa, Lorena Meneses, Patricio Rojas‐Silva, Sonia Zapata, Fabián E. Saénz, Miryan Rivera I., Jaime A. CostalesList of authors in order
- Landing page
-
https://doi.org/10.1128/spectrum.03339-23Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1128/spectrum.03339-23Direct OA link when available
- Concepts
-
Trypanosoma cruzi, Leishmania mexicana, Plasmodium falciparum, Biology, Leishmania, Protozoa, Trypanosoma, Parasite hosting, Virology, Microbiology, Immunology, Malaria, World Wide Web, Computer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5Per-year citation counts (last 5 years)
- References (count)
-
61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4400686116 |
|---|---|
| doi | https://doi.org/10.1128/spectrum.03339-23 |
| ids.doi | https://doi.org/10.1128/spectrum.03339-23 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39012112 |
| ids.openalex | https://openalex.org/W4400686116 |
| fwci | 6.72883065 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000187 |
| mesh[1].descriptor_ui | D014349 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | drug effects |
| mesh[1].descriptor_name | Trypanosoma cruzi |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D001001 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Anura |
| mesh[3].qualifier_ui | Q000187 |
| mesh[3].descriptor_ui | D010963 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | drug effects |
| mesh[3].descriptor_name | Plasmodium falciparum |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D006801 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Humans |
| mesh[5].qualifier_ui | Q000187 |
| mesh[5].descriptor_ui | D007894 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | drug effects |
| mesh[5].descriptor_name | Leishmania mexicana |
| mesh[6].qualifier_ui | Q000469 |
| mesh[6].descriptor_ui | D012867 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | parasitology |
| mesh[6].descriptor_name | Skin |
| mesh[7].qualifier_ui | Q000187 |
| mesh[7].descriptor_ui | D012867 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | drug effects |
| mesh[7].descriptor_name | Skin |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D008826 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Microbial Sensitivity Tests |
| mesh[9].qualifier_ui | Q000494 |
| mesh[9].descriptor_ui | D023181 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | pharmacology |
| mesh[9].descriptor_name | Antimicrobial Cationic Peptides |
| mesh[10].qualifier_ui | Q000737 |
| mesh[10].descriptor_ui | D023181 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | chemistry |
| mesh[10].descriptor_name | Antimicrobial Cationic Peptides |
| mesh[11].qualifier_ui | Q000494 |
| mesh[11].descriptor_ui | D000089882 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | pharmacology |
| mesh[11].descriptor_name | Antimicrobial Peptides |
| mesh[12].qualifier_ui | Q000737 |
| mesh[12].descriptor_ui | D000089882 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | chemistry |
| mesh[12].descriptor_name | Antimicrobial Peptides |
| mesh[13].qualifier_ui | Q000494 |
| mesh[13].descriptor_ui | D029845 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | pharmacology |
| mesh[13].descriptor_name | Amphibian Proteins |
| mesh[14].qualifier_ui | Q000737 |
| mesh[14].descriptor_ui | D029845 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | chemistry |
| mesh[14].descriptor_name | Amphibian Proteins |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D004484 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Ecuador |
| mesh[16].qualifier_ui | Q000188 |
| mesh[16].descriptor_ui | D014355 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | drug therapy |
| mesh[16].descriptor_name | Chagas Disease |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D000818 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Animals |
| mesh[18].qualifier_ui | Q000187 |
| mesh[18].descriptor_ui | D014349 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | drug effects |
| mesh[18].descriptor_name | Trypanosoma cruzi |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D001001 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Anura |
| mesh[20].qualifier_ui | Q000187 |
| mesh[20].descriptor_ui | D010963 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | drug effects |
| mesh[20].descriptor_name | Plasmodium falciparum |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D006801 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Humans |
| mesh[22].qualifier_ui | Q000187 |
| mesh[22].descriptor_ui | D007894 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | drug effects |
| mesh[22].descriptor_name | Leishmania mexicana |
| mesh[23].qualifier_ui | Q000469 |
| mesh[23].descriptor_ui | D012867 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | parasitology |
| mesh[23].descriptor_name | Skin |
| mesh[24].qualifier_ui | Q000187 |
| mesh[24].descriptor_ui | D012867 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | drug effects |
| mesh[24].descriptor_name | Skin |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D008826 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Microbial Sensitivity Tests |
| mesh[26].qualifier_ui | Q000494 |
| mesh[26].descriptor_ui | D023181 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | pharmacology |
| mesh[26].descriptor_name | Antimicrobial Cationic Peptides |
| mesh[27].qualifier_ui | Q000737 |
| mesh[27].descriptor_ui | D023181 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | chemistry |
| mesh[27].descriptor_name | Antimicrobial Cationic Peptides |
| mesh[28].qualifier_ui | Q000494 |
| mesh[28].descriptor_ui | D000089882 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | pharmacology |
| mesh[28].descriptor_name | Antimicrobial Peptides |
| mesh[29].qualifier_ui | Q000737 |
| mesh[29].descriptor_ui | D000089882 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | chemistry |
| mesh[29].descriptor_name | Antimicrobial Peptides |
| mesh[30].qualifier_ui | Q000494 |
| mesh[30].descriptor_ui | D029845 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | pharmacology |
| mesh[30].descriptor_name | Amphibian Proteins |
| mesh[31].qualifier_ui | Q000737 |
| mesh[31].descriptor_ui | D029845 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | chemistry |
| mesh[31].descriptor_name | Amphibian Proteins |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D004484 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Ecuador |
| mesh[33].qualifier_ui | Q000188 |
| mesh[33].descriptor_ui | D014355 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | drug therapy |
| mesh[33].descriptor_name | Chagas Disease |
| type | article |
| title | Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana , Plasmodium falciparum , and Trypanosoma cruzi |
| biblio.issue | 8 |
| biblio.volume | 12 |
| biblio.last_page | e0333923 |
| biblio.first_page | e0333923 |
| grants[0].funder | https://openalex.org/F4320318862 |
| grants[0].award_id | CEPRA XV-2021-10 |
| grants[0].funder_display_name | Corporación Ecuatoriana para el Desarrollo de la Investigación y la Academia |
| grants[1].funder | https://openalex.org/F4320327255 |
| grants[1].award_id | 044-UIO-2023 |
| grants[1].funder_display_name | Pontificia Universidad Católica del Ecuador |
| topics[0].id | https://openalex.org/T10823 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2739 |
| topics[0].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[0].display_name | Research on Leishmaniasis Studies |
| topics[1].id | https://openalex.org/T10890 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9955999851226807 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2713 |
| topics[1].subfield.display_name | Epidemiology |
| topics[1].display_name | Trypanosoma species research and implications |
| topics[2].id | https://openalex.org/T11065 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.9789000153541565 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1110 |
| topics[2].subfield.display_name | Plant Science |
| topics[2].display_name | Insect Pest Control Strategies |
| funders[0].id | https://openalex.org/F4320318862 |
| funders[0].ror | |
| funders[0].display_name | Corporación Ecuatoriana para el Desarrollo de la Investigación y la Academia |
| funders[1].id | https://openalex.org/F4320327255 |
| funders[1].ror | https://ror.org/02qztda51 |
| funders[1].display_name | Pontificia Universidad Católica del Ecuador |
| is_xpac | False |
| apc_list.value | 2500 |
| apc_list.currency | USD |
| apc_list.value_usd | 2500 |
| apc_paid.value | 2500 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2500 |
| concepts[0].id | https://openalex.org/C2777625466 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8595477938652039 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q150162 |
| concepts[0].display_name | Trypanosoma cruzi |
| concepts[1].id | https://openalex.org/C2781371782 |
| concepts[1].level | 4 |
| concepts[1].score | 0.7974308133125305 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2493771 |
| concepts[1].display_name | Leishmania mexicana |
| concepts[2].id | https://openalex.org/C2778371730 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6514722108840942 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q311383 |
| concepts[2].display_name | Plasmodium falciparum |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.6265147924423218 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C2781092759 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5991818904876709 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q524818 |
| concepts[4].display_name | Leishmania |
| concepts[5].id | https://openalex.org/C2778566189 |
| concepts[5].level | 2 |
| concepts[5].score | 0.583854615688324 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q101274 |
| concepts[5].display_name | Protozoa |
| concepts[6].id | https://openalex.org/C2779549974 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4931585192680359 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q541987 |
| concepts[6].display_name | Trypanosoma |
| concepts[7].id | https://openalex.org/C71928629 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4791821241378784 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q804206 |
| concepts[7].display_name | Parasite hosting |
| concepts[8].id | https://openalex.org/C159047783 |
| concepts[8].level | 1 |
| concepts[8].score | 0.44452357292175293 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[8].display_name | Virology |
| concepts[9].id | https://openalex.org/C89423630 |
| concepts[9].level | 1 |
| concepts[9].score | 0.39148637652397156 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7193 |
| concepts[9].display_name | Microbiology |
| concepts[10].id | https://openalex.org/C203014093 |
| concepts[10].level | 1 |
| concepts[10].score | 0.27144360542297363 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[10].display_name | Immunology |
| concepts[11].id | https://openalex.org/C2778048844 |
| concepts[11].level | 2 |
| concepts[11].score | 0.22728806734085083 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q12156 |
| concepts[11].display_name | Malaria |
| concepts[12].id | https://openalex.org/C136764020 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q466 |
| concepts[12].display_name | World Wide Web |
| concepts[13].id | https://openalex.org/C41008148 |
| concepts[13].level | 0 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[13].display_name | Computer science |
| keywords[0].id | https://openalex.org/keywords/trypanosoma-cruzi |
| keywords[0].score | 0.8595477938652039 |
| keywords[0].display_name | Trypanosoma cruzi |
| keywords[1].id | https://openalex.org/keywords/leishmania-mexicana |
| keywords[1].score | 0.7974308133125305 |
| keywords[1].display_name | Leishmania mexicana |
| keywords[2].id | https://openalex.org/keywords/plasmodium-falciparum |
| keywords[2].score | 0.6514722108840942 |
| keywords[2].display_name | Plasmodium falciparum |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.6265147924423218 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/leishmania |
| keywords[4].score | 0.5991818904876709 |
| keywords[4].display_name | Leishmania |
| keywords[5].id | https://openalex.org/keywords/protozoa |
| keywords[5].score | 0.583854615688324 |
| keywords[5].display_name | Protozoa |
| keywords[6].id | https://openalex.org/keywords/trypanosoma |
| keywords[6].score | 0.4931585192680359 |
| keywords[6].display_name | Trypanosoma |
| keywords[7].id | https://openalex.org/keywords/parasite-hosting |
| keywords[7].score | 0.4791821241378784 |
| keywords[7].display_name | Parasite hosting |
| keywords[8].id | https://openalex.org/keywords/virology |
| keywords[8].score | 0.44452357292175293 |
| keywords[8].display_name | Virology |
| keywords[9].id | https://openalex.org/keywords/microbiology |
| keywords[9].score | 0.39148637652397156 |
| keywords[9].display_name | Microbiology |
| keywords[10].id | https://openalex.org/keywords/immunology |
| keywords[10].score | 0.27144360542297363 |
| keywords[10].display_name | Immunology |
| keywords[11].id | https://openalex.org/keywords/malaria |
| keywords[11].score | 0.22728806734085083 |
| keywords[11].display_name | Malaria |
| language | en |
| locations[0].id | doi:10.1128/spectrum.03339-23 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2764766708 |
| locations[0].source.issn | 2165-0497 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2165-0497 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Microbiology Spectrum |
| locations[0].source.host_organization | https://openalex.org/P4310320263 |
| locations[0].source.host_organization_name | American Society for Microbiology |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320263 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Microbiology Spectrum |
| locations[0].landing_page_url | https://doi.org/10.1128/spectrum.03339-23 |
| locations[1].id | pmid:39012112 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Microbiology spectrum |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39012112 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11302733 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Microbiol Spectr |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11302733 |
| locations[3].id | pmh:oai:doaj.org/article:8c6f724342844de3b832b9d3c9f6bf05 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Microbiology Spectrum, Vol 12, Iss 8 (2024) |
| locations[3].landing_page_url | https://doaj.org/article/8c6f724342844de3b832b9d3c9f6bf05 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5091227903 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-9279-1038 |
| authorships[0].author.display_name | Carolina Proaño‐Bolaños |
| authorships[0].countries | EC |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210161473 |
| authorships[0].affiliations[0].raw_affiliation_string | Biomolecules Discovery Group, Laboratory of Molecular Biology and Biochemistry, Universidad Regional Amazónica Ikiam, Tena, Ecuador |
| authorships[0].institutions[0].id | https://openalex.org/I4210161473 |
| authorships[0].institutions[0].ror | https://ror.org/05xedqd83 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210161473 |
| authorships[0].institutions[0].country_code | EC |
| authorships[0].institutions[0].display_name | Universidad Regional Amazónica IKIAM |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Carolina Proaño-Bolaños |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Biomolecules Discovery Group, Laboratory of Molecular Biology and Biochemistry, Universidad Regional Amazónica Ikiam, Tena, Ecuador |
| authorships[1].author.id | https://openalex.org/A5061864368 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Giovanna Morán-Marcillo |
| authorships[1].countries | EC |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210161473 |
| authorships[1].affiliations[0].raw_affiliation_string | Biomolecules Discovery Group, Laboratory of Molecular Biology and Biochemistry, Universidad Regional Amazónica Ikiam, Tena, Ecuador |
| authorships[1].institutions[0].id | https://openalex.org/I4210161473 |
| authorships[1].institutions[0].ror | https://ror.org/05xedqd83 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210161473 |
| authorships[1].institutions[0].country_code | EC |
| authorships[1].institutions[0].display_name | Universidad Regional Amazónica IKIAM |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Giovanna Morán-Marcillo |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Biomolecules Discovery Group, Laboratory of Molecular Biology and Biochemistry, Universidad Regional Amazónica Ikiam, Tena, Ecuador |
| authorships[2].author.id | https://openalex.org/A5034118723 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-7503-1165 |
| authorships[2].author.display_name | Nina Espinosa de los Monteros‐Silva |
| authorships[2].countries | EC |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210161473 |
| authorships[2].affiliations[0].raw_affiliation_string | Biomolecules Discovery Group, Laboratory of Molecular Biology and Biochemistry, Universidad Regional Amazónica Ikiam, Tena, Ecuador |
| authorships[2].institutions[0].id | https://openalex.org/I4210161473 |
| authorships[2].institutions[0].ror | https://ror.org/05xedqd83 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210161473 |
| authorships[2].institutions[0].country_code | EC |
| authorships[2].institutions[0].display_name | Universidad Regional Amazónica IKIAM |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Nina Espinosa de los Monteros-Silva |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Biomolecules Discovery Group, Laboratory of Molecular Biology and Biochemistry, Universidad Regional Amazónica Ikiam, Tena, Ecuador |
| authorships[3].author.id | https://openalex.org/A5045916729 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-7356-8655 |
| authorships[3].author.display_name | Sebastián Bermúdez-Puga |
| authorships[3].countries | BR, EC |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I17974374 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biochemical-Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I4210161473 |
| authorships[3].affiliations[1].raw_affiliation_string | Biomolecules Discovery Group, Laboratory of Molecular Biology and Biochemistry, Universidad Regional Amazónica Ikiam, Tena, Ecuador |
| authorships[3].institutions[0].id | https://openalex.org/I17974374 |
| authorships[3].institutions[0].ror | https://ror.org/036rp1748 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I17974374 |
| authorships[3].institutions[0].country_code | BR |
| authorships[3].institutions[0].display_name | Universidade de São Paulo |
| authorships[3].institutions[1].id | https://openalex.org/I4210161473 |
| authorships[3].institutions[1].ror | https://ror.org/05xedqd83 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210161473 |
| authorships[3].institutions[1].country_code | EC |
| authorships[3].institutions[1].display_name | Universidad Regional Amazónica IKIAM |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Sebastián Bermúdez-Puga |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Biomolecules Discovery Group, Laboratory of Molecular Biology and Biochemistry, Universidad Regional Amazónica Ikiam, Tena, Ecuador, Department of Biochemical-Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil |
| authorships[4].author.id | https://openalex.org/A5057187537 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1225-7140 |
| authorships[4].author.display_name | Mateo Alejandro Salazar |
| authorships[4].countries | EC |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I39398033 |
| authorships[4].affiliations[0].raw_affiliation_string | Laboratorio de Investigación en Citogenética y Biomoléculas de Anfibios (LICBA), Centro de Investigación para la Salud en América Latina (CISeAL), Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I39398033 |
| authorships[4].affiliations[1].raw_affiliation_string | Centro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[4].institutions[0].id | https://openalex.org/I39398033 |
| authorships[4].institutions[0].ror | https://ror.org/02qztda51 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I39398033 |
| authorships[4].institutions[0].country_code | EC |
| authorships[4].institutions[0].display_name | Pontificia Universidad Católica del Ecuador |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Mateo A. Salazar |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Centro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Ecuador, Laboratorio de Investigación en Citogenética y Biomoléculas de Anfibios (LICBA), Centro de Investigación para la Salud en América Latina (CISeAL), Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[5].author.id | https://openalex.org/A5086432299 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-7318-2795 |
| authorships[5].author.display_name | Ailín Blasco-Zúñiga |
| authorships[5].countries | EC |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I39398033 |
| authorships[5].affiliations[0].raw_affiliation_string | Laboratorio de Investigación en Citogenética y Biomoléculas de Anfibios (LICBA), Centro de Investigación para la Salud en América Latina (CISeAL), Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[5].institutions[0].id | https://openalex.org/I39398033 |
| authorships[5].institutions[0].ror | https://ror.org/02qztda51 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I39398033 |
| authorships[5].institutions[0].country_code | EC |
| authorships[5].institutions[0].display_name | Pontificia Universidad Católica del Ecuador |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Ailín Blasco-Zúñiga |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Laboratorio de Investigación en Citogenética y Biomoléculas de Anfibios (LICBA), Centro de Investigación para la Salud en América Latina (CISeAL), Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[6].author.id | https://openalex.org/A5066714744 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-8035-6220 |
| authorships[6].author.display_name | Sebastián A. Cuesta |
| authorships[6].countries | EC |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I39398033 |
| authorships[6].affiliations[0].raw_affiliation_string | Laboratorio de Química Computacional, Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[6].institutions[0].id | https://openalex.org/I39398033 |
| authorships[6].institutions[0].ror | https://ror.org/02qztda51 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I39398033 |
| authorships[6].institutions[0].country_code | EC |
| authorships[6].institutions[0].display_name | Pontificia Universidad Católica del Ecuador |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Sebastián Cuesta |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Laboratorio de Química Computacional, Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[7].author.id | https://openalex.org/A5111334890 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Carolina Molina |
| authorships[7].countries | EC |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I69094615 |
| authorships[7].affiliations[0].raw_affiliation_string | Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador |
| authorships[7].institutions[0].id | https://openalex.org/I69094615 |
| authorships[7].institutions[0].ror | https://ror.org/01r2c3v86 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I69094615 |
| authorships[7].institutions[0].country_code | EC |
| authorships[7].institutions[0].display_name | Universidad San Francisco de Quito |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Carolina Molina |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador |
| authorships[8].author.id | https://openalex.org/A5091527092 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-9905-1785 |
| authorships[8].author.display_name | Franklin Espinosa |
| authorships[8].countries | EC |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I69094615 |
| authorships[8].affiliations[0].raw_affiliation_string | Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador |
| authorships[8].institutions[0].id | https://openalex.org/I69094615 |
| authorships[8].institutions[0].ror | https://ror.org/01r2c3v86 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I69094615 |
| authorships[8].institutions[0].country_code | EC |
| authorships[8].institutions[0].display_name | Universidad San Francisco de Quito |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Franklin Espinosa |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador |
| authorships[9].author.id | https://openalex.org/A5032959201 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-1517-5247 |
| authorships[9].author.display_name | Lorena Meneses |
| authorships[9].countries | EC |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I39398033 |
| authorships[9].affiliations[0].raw_affiliation_string | Laboratorio de Química Computacional, Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[9].institutions[0].id | https://openalex.org/I39398033 |
| authorships[9].institutions[0].ror | https://ror.org/02qztda51 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I39398033 |
| authorships[9].institutions[0].country_code | EC |
| authorships[9].institutions[0].display_name | Pontificia Universidad Católica del Ecuador |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Lorena Meneses |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Laboratorio de Química Computacional, Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[10].author.id | https://openalex.org/A5047125307 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9611-3661 |
| authorships[10].author.display_name | Patricio Rojas‐Silva |
| authorships[10].countries | EC |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I69094615 |
| authorships[10].affiliations[0].raw_affiliation_string | Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador |
| authorships[10].institutions[0].id | https://openalex.org/I69094615 |
| authorships[10].institutions[0].ror | https://ror.org/01r2c3v86 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I69094615 |
| authorships[10].institutions[0].country_code | EC |
| authorships[10].institutions[0].display_name | Universidad San Francisco de Quito |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Patricio Rojas-Silva |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador |
| authorships[11].author.id | https://openalex.org/A5048971840 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-0499-1262 |
| authorships[11].author.display_name | Sonia Zapata |
| authorships[11].countries | EC |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I69094615 |
| authorships[11].affiliations[0].raw_affiliation_string | Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador |
| authorships[11].institutions[0].id | https://openalex.org/I69094615 |
| authorships[11].institutions[0].ror | https://ror.org/01r2c3v86 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I69094615 |
| authorships[11].institutions[0].country_code | EC |
| authorships[11].institutions[0].display_name | Universidad San Francisco de Quito |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Sonia Zapata Mena |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador |
| authorships[12].author.id | https://openalex.org/A5059495408 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-6460-5373 |
| authorships[12].author.display_name | Fabián E. Saénz |
| authorships[12].countries | EC |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I39398033 |
| authorships[12].affiliations[0].raw_affiliation_string | Centro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[12].institutions[0].id | https://openalex.org/I39398033 |
| authorships[12].institutions[0].ror | https://ror.org/02qztda51 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I39398033 |
| authorships[12].institutions[0].country_code | EC |
| authorships[12].institutions[0].display_name | Pontificia Universidad Católica del Ecuador |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Fabián E. Sáenz |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Centro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[13].author.id | https://openalex.org/A5111258854 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | Miryan Rivera I. |
| authorships[13].countries | EC |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I39398033 |
| authorships[13].affiliations[0].raw_affiliation_string | Laboratorio de Investigación en Citogenética y Biomoléculas de Anfibios (LICBA), Centro de Investigación para la Salud en América Latina (CISeAL), Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[13].institutions[0].id | https://openalex.org/I39398033 |
| authorships[13].institutions[0].ror | https://ror.org/02qztda51 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I39398033 |
| authorships[13].institutions[0].country_code | EC |
| authorships[13].institutions[0].display_name | Pontificia Universidad Católica del Ecuador |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Miryan Rivera I. |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Laboratorio de Investigación en Citogenética y Biomoléculas de Anfibios (LICBA), Centro de Investigación para la Salud en América Latina (CISeAL), Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[14].author.id | https://openalex.org/A5057047319 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-9418-6640 |
| authorships[14].author.display_name | Jaime A. Costales |
| authorships[14].countries | EC |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I39398033 |
| authorships[14].affiliations[0].raw_affiliation_string | Centro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| authorships[14].institutions[0].id | https://openalex.org/I39398033 |
| authorships[14].institutions[0].ror | https://ror.org/02qztda51 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I39398033 |
| authorships[14].institutions[0].country_code | EC |
| authorships[14].institutions[0].display_name | Pontificia Universidad Católica del Ecuador |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Jaime A. Costales |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Centro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Ecuador |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1128/spectrum.03339-23 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2024-07-17T00:00:00 |
| display_name | Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana , Plasmodium falciparum , and Trypanosoma cruzi |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10823 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2739 |
| primary_topic.subfield.display_name | Public Health, Environmental and Occupational Health |
| primary_topic.display_name | Research on Leishmaniasis Studies |
| related_works | https://openalex.org/W2946783001, https://openalex.org/W1689351549, https://openalex.org/W2056027193, https://openalex.org/W2209456429, https://openalex.org/W2042142194, https://openalex.org/W2331820052, https://openalex.org/W1526361444, https://openalex.org/W4388325001, https://openalex.org/W2068637301, https://openalex.org/W2585378430 |
| cited_by_count | 5 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1128/spectrum.03339-23 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764766708 |
| best_oa_location.source.issn | 2165-0497 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2165-0497 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Microbiology Spectrum |
| best_oa_location.source.host_organization | https://openalex.org/P4310320263 |
| best_oa_location.source.host_organization_name | American Society for Microbiology |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320263 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Microbiology Spectrum |
| best_oa_location.landing_page_url | https://doi.org/10.1128/spectrum.03339-23 |
| primary_location.id | doi:10.1128/spectrum.03339-23 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2764766708 |
| primary_location.source.issn | 2165-0497 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2165-0497 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Microbiology Spectrum |
| primary_location.source.host_organization | https://openalex.org/P4310320263 |
| primary_location.source.host_organization_name | American Society for Microbiology |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320263 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Microbiology Spectrum |
| primary_location.landing_page_url | https://doi.org/10.1128/spectrum.03339-23 |
| publication_date | 2024-07-16 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2954792327, https://openalex.org/W4211073781, https://openalex.org/W2725449842, https://openalex.org/W3110066267, https://openalex.org/W2689455564, https://openalex.org/W2075874382, https://openalex.org/W2157230858, https://openalex.org/W3176042341, https://openalex.org/W2763660888, https://openalex.org/W2618705397, https://openalex.org/W2942281207, https://openalex.org/W3137057920, https://openalex.org/W4310565462, https://openalex.org/W4211099777, https://openalex.org/W2072375986, https://openalex.org/W3180326162, https://openalex.org/W2108305786, https://openalex.org/W3087439566, https://openalex.org/W2073406729, https://openalex.org/W2025085131, https://openalex.org/W2152653048, https://openalex.org/W2103832463, https://openalex.org/W1978260666, https://openalex.org/W1987992920, https://openalex.org/W2030394100, https://openalex.org/W4281678061, https://openalex.org/W3157225480, https://openalex.org/W2439167311, https://openalex.org/W2982693797, https://openalex.org/W3084981380, https://openalex.org/W2171765967, https://openalex.org/W1969503178, https://openalex.org/W2007511846, https://openalex.org/W2032980181, https://openalex.org/W2584811688, https://openalex.org/W2012834249, https://openalex.org/W1984150500, https://openalex.org/W2114818342, https://openalex.org/W2058743119, https://openalex.org/W2807363837, https://openalex.org/W2055043387, https://openalex.org/W2799524357, https://openalex.org/W2117484859, https://openalex.org/W1536886974, https://openalex.org/W2119993590, https://openalex.org/W2029476353, https://openalex.org/W2153187042, https://openalex.org/W2118817344, https://openalex.org/W2075231437, https://openalex.org/W2134967712, https://openalex.org/W3048097141, https://openalex.org/W2034237547, https://openalex.org/W2164725520, https://openalex.org/W2082060764, https://openalex.org/W1690540890, https://openalex.org/W2045775089, https://openalex.org/W2088823726, https://openalex.org/W4214683148, https://openalex.org/W2278666748, https://openalex.org/W2314372796, https://openalex.org/W4220912136 |
| referenced_works_count | 61 |
| abstract_inverted_index., | 139, 142, 324, 327 |
| abstract_inverted_index.. | 118, 181, 331 |
| abstract_inverted_index.; | 107, 112 |
| abstract_inverted_index.a | 243 |
| abstract_inverted_index.In | 199 |
| abstract_inverted_index.We | 291 |
| abstract_inverted_index.as | 288, 321 |
| abstract_inverted_index.in | 15, 179, 212, 217 |
| abstract_inverted_index.is | 27, 349, 380 |
| abstract_inverted_index.it | 354, 369 |
| abstract_inverted_index.of | 30, 34, 52, 68, 73, 88, 95, 129, 151, 168, 174, 194, 246, 273, 300, 303, 311, 315, 342, 344, 350 |
| abstract_inverted_index.to | 23, 241 |
| abstract_inverted_index.we | 83 |
| abstract_inverted_index.AMP | 238 |
| abstract_inverted_index.All | 332 |
| abstract_inverted_index.The | 182 |
| abstract_inverted_index.and | 4, 49, 102, 113, 131, 143, 158, 171, 224, 253, 263, 276, 306, 328 |
| abstract_inverted_index.are | 6, 63, 239, 255, 270 |
| abstract_inverted_index.for | 45, 265 |
| abstract_inverted_index.its | 132, 247, 378 |
| abstract_inverted_index.low | 77, 228 |
| abstract_inverted_index.may | 207 |
| abstract_inverted_index.not | 371 |
| abstract_inverted_index.one | 341 |
| abstract_inverted_index.the | 12, 31, 38, 43, 50, 70, 85, 126, 149, 152, 188, 213, 297, 312, 333, 345, 383 |
| abstract_inverted_index.via | 209 |
| abstract_inverted_index.AMPs | 90, 121, 154, 184 |
| abstract_inverted_index.Frog | 279 |
| abstract_inverted_index.cell | 71 |
| abstract_inverted_index.coli | 138 |
| abstract_inverted_index.does | 370 |
| abstract_inverted_index.five | 89, 120, 183, 293 |
| abstract_inverted_index.from | 59, 92, 104, 109, 115, 296 |
| abstract_inverted_index.gain | 242 |
| abstract_inverted_index.hold | 373 |
| abstract_inverted_index.long | 46 |
| abstract_inverted_index.more | 343 |
| abstract_inverted_index.need | 44 |
| abstract_inverted_index.new, | 19 |
| abstract_inverted_index.pore | 210 |
| abstract_inverted_index.side | 39, 277 |
| abstract_inverted_index.skin | 61, 93, 280, 298 |
| abstract_inverted_index.that | 259 |
| abstract_inverted_index.them | 308 |
| abstract_inverted_index.they | 41 |
| abstract_inverted_index.this | 205, 236 |
| abstract_inverted_index.were | 122, 146, 177 |
| abstract_inverted_index.with | 191, 227, 284 |
| abstract_inverted_index.Boana | 116 |
| abstract_inverted_index.CZS-4 | 130, 220 |
| abstract_inverted_index.Here, | 82 |
| abstract_inverted_index.These | 119 |
| abstract_inverted_index.about | 235 |
| abstract_inverted_index.being | 361 |
| abstract_inverted_index.cause | 260 |
| abstract_inverted_index.cells | 157 |
| abstract_inverted_index.cruzi | 176, 323 |
| abstract_inverted_index.frogs | 305 |
| abstract_inverted_index.human | 80 |
| abstract_inverted_index.known | 287, 320 |
| abstract_inverted_index.major | 7, 256 |
| abstract_inverted_index.occur | 208 |
| abstract_inverted_index.since | 353 |
| abstract_inverted_index.small | 64 |
| abstract_inverted_index.their | 159 |
| abstract_inverted_index.these | 25, 316 |
| abstract_inverted_index.three | 96, 317 |
| abstract_inverted_index.toxic | 375 |
| abstract_inverted_index.treat | 24 |
| abstract_inverted_index.vitro | 180 |
| abstract_inverted_index.which | 266, 367 |
| abstract_inverted_index.while | 75, 360 |
| abstract_inverted_index.(AMPs) | 57 |
| abstract_inverted_index.Chagas | 1, 250 |
| abstract_inverted_index.agents | 314 |
| abstract_inverted_index.aureus | 141 |
| abstract_inverted_index.better | 244 |
| abstract_inverted_index.cause, | 42 |
| abstract_inverted_index.cells, | 366 |
| abstract_inverted_index.cells. | 81, 198, 232 |
| abstract_inverted_index.frogs: | 98 |
| abstract_inverted_index.having | 76 |
| abstract_inverted_index.levels | 193 |
| abstract_inverted_index.lysing | 69 |
| abstract_inverted_index.lysis. | 219 |
| abstract_inverted_index.number | 33 |
| abstract_inverted_index.plasma | 214 |
| abstract_inverted_index.report | 84 |
| abstract_inverted_index.showed | 338 |
| abstract_inverted_index.silico | 200 |
| abstract_inverted_index.simply | 372 |
| abstract_inverted_index.stages | 167, 173 |
| abstract_inverted_index.tested | 307 |
| abstract_inverted_index.Candida | 144 |
| abstract_inverted_index.Finding | 18 |
| abstract_inverted_index.Further | 233 |
| abstract_inverted_index.Peptide | 347 |
| abstract_inverted_index.against | 79, 136, 155, 162, 187, 196, 230, 309, 340, 358, 363, 382 |
| abstract_inverted_index.because | 29, 272 |
| abstract_inverted_index.capable | 67 |
| abstract_inverted_index.contain | 282 |
| abstract_inverted_index.crucial | 28 |
| abstract_inverted_index.derived | 58, 91, 295 |
| abstract_inverted_index.docking | 202 |
| abstract_inverted_index.effects | 40 |
| abstract_inverted_index.general | 374 |
| abstract_inverted_index.intense | 356 |
| abstract_inverted_index.limited | 32, 274 |
| abstract_inverted_index.malaria | 5 |
| abstract_inverted_index.minimal | 133 |
| abstract_inverted_index.options | 35, 269 |
| abstract_inverted_index.rather, | 377 |
| abstract_inverted_index.special | 351 |
| abstract_inverted_index.species | 302 |
| abstract_inverted_index.studied | 337 |
| abstract_inverted_index.studies | 234 |
| abstract_inverted_index.(CZS-4), | 101 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.activity | 87, 128, 161, 186, 339, 357, 379 |
| abstract_inverted_index.albicans | 145 |
| abstract_inverted_index.analysis | 203 |
| abstract_inverted_index.courses, | 48 |
| abstract_inverted_index.cultured | 364 |
| abstract_inverted_index.cultures | 310 |
| abstract_inverted_index.disease, | 2, 251 |
| abstract_inverted_index.diseases | 9, 26, 258 |
| abstract_inverted_index.effects. | 278 |
| abstract_inverted_index.efficacy | 275 |
| abstract_inverted_index.interest | 352 |
| abstract_inverted_index.malaria, | 252 |
| abstract_inverted_index.membrane | 72 |
| abstract_inverted_index.mexicana | 164, 330 |
| abstract_inverted_index.nations. | 17 |
| abstract_inverted_index.peptides | 56, 294, 336 |
| abstract_inverted_index.required | 240 |
| abstract_inverted_index.specific | 381 |
| abstract_inverted_index.studied, | 190 |
| abstract_inverted_index.suggests | 204 |
| abstract_inverted_index.toxicity | 78 |
| abstract_inverted_index.tropical | 257, 304 |
| abstract_inverted_index.activity. | 248 |
| abstract_inverted_index.affecting | 11 |
| abstract_inverted_index.amphibian | 60 |
| abstract_inverted_index.available | 267 |
| abstract_inverted_index.bioactive | 65 |
| abstract_inverted_index.causative | 313 |
| abstract_inverted_index.compounds | 22 |
| abstract_inverted_index.currently | 36 |
| abstract_inverted_index.different | 192, 301, 334 |
| abstract_inverted_index.diseases, | 318 |
| abstract_inverted_index.displayed | 185, 221, 355 |
| abstract_inverted_index.emergence | 51 |
| abstract_inverted_index.evaluated | 178 |
| abstract_inverted_index.extensive | 261 |
| abstract_inverted_index.formation | 211 |
| abstract_inverted_index.hemolytic | 127 |
| abstract_inverted_index.indicates | 368 |
| abstract_inverted_index.innocuous | 362 |
| abstract_inverted_index.mammalian | 156, 172, 197, 231, 365 |
| abstract_inverted_index.membrane, | 215 |
| abstract_inverted_index.microbial | 218 |
| abstract_inverted_index.molecular | 201 |
| abstract_inverted_index.molecules | 66, 283 |
| abstract_inverted_index.morbidity | 262 |
| abstract_inverted_index.parasites | 319, 359 |
| abstract_inverted_index.parasitic | 8 |
| abstract_inverted_index.pathogens | 74, 189 |
| abstract_inverted_index.peptides. | 290 |
| abstract_inverted_index.picturata | 117 |
| abstract_inverted_index.promising | 237 |
| abstract_inverted_index.resulting | 216 |
| abstract_inverted_index.spurrelli | 111 |
| abstract_inverted_index.synthetic | 153, 335 |
| abstract_inverted_index.treatment | 47, 268 |
| abstract_inverted_index.Agalychnis | 110 |
| abstract_inverted_index.Cruziohyla | 105 |
| abstract_inverted_index.Ecuadorian | 97 |
| abstract_inverted_index.IMPORTANCE | 249 |
| abstract_inverted_index.Initially, | 125 |
| abstract_inverted_index.Leishmania | 163, 329 |
| abstract_inverted_index.Plasmodium | 169, 325 |
| abstract_inverted_index.activities | 226 |
| abstract_inverted_index.available, | 37 |
| abstract_inverted_index.calcarifer | 106 |
| abstract_inverted_index.chemically | 123 |
| abstract_inverted_index.developing | 16 |
| abstract_inverted_index.falciparum | 170, 326 |
| abstract_inverted_index.inhibitory | 134 |
| abstract_inverted_index.mortality, | 264 |
| abstract_inverted_index.parasites. | 54, 346, 384 |
| abstract_inverted_index.population | 14 |
| abstract_inverted_index.properties | 286 |
| abstract_inverted_index.secretions | 62, 94, 281, 299 |
| abstract_inverted_index.Escherichia | 137 |
| abstract_inverted_index.Trypanosoma | 175, 322 |
| abstract_inverted_index.alternative | 20 |
| abstract_inverted_index.bioactivity | 206 |
| abstract_inverted_index.determined. | 147 |
| abstract_inverted_index.properties; | 376 |
| abstract_inverted_index.synthesized | 292 |
| abstract_inverted_index.anti-fungal, | 223 |
| abstract_inverted_index.cytotoxicity | 150, 195, 229 |
| abstract_inverted_index.erythrocytic | 166 |
| abstract_inverted_index.synthesized. | 124 |
| abstract_inverted_index.Subsequently, | 148 |
| abstract_inverted_index.concentration | 135 |
| abstract_inverted_index.leishmaniasis | 254 |
| abstract_inverted_index.pictuseptin-1 | 114 |
| abstract_inverted_index.understanding | 245 |
| abstract_inverted_index.Anti-microbial | 55 |
| abstract_inverted_index.Staphylococcus | 140 |
| abstract_inverted_index.anti-microbial | 285, 289 |
| abstract_inverted_index.anti-parasitic | 21, 86, 160, 225 |
| abstract_inverted_index.cruzioseptin-4 | 100, 348 |
| abstract_inverted_index.drug-resistant | 53 |
| abstract_inverted_index.leishmaniasis, | 3 |
| abstract_inverted_index.promastigotes, | 165 |
| abstract_inverted_index.unsatisfactory | 271 |
| abstract_inverted_index.anti-bacterial, | 222 |
| abstract_inverted_index.cruzioseptin-1, | 99 |
| abstract_inverted_index.cruzioseptin-16 | 103 |
| abstract_inverted_index.dermaseptin-SP2 | 108 |
| abstract_inverted_index.underprivileged | 13 |
| abstract_inverted_index.disproportionately | 10 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 15 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/17 |
| sustainable_development_goals[0].score | 0.5199999809265137 |
| sustainable_development_goals[0].display_name | Partnerships for the goals |
| citation_normalized_percentile.value | 0.93150936 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |