Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor Article Swipe
Tauqeer Hussain Mallhi
,
Momina Shahid
,
Kanwal Rehman
,
Yusra Habib Khan
,
Abdullah Salah Alanazi
,
Nasser Hadal Alotaibi
,
Muhammad Sajid Hamid Akash
,
Muhammad Hammad Butt
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/metabo13020251
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/metabo13020251
Myocardial infarction (MI) is a cardiovascular disease that occurs due to the blockage of the coronary artery. Subsequently, cardiac muscles receive a lower oxygen supply, which leads to the death of cardiac muscles. The etiology of MI is linked to various environmental, occupational, and genetic factors. Various studies have been conducted on the polymorphism of genes involved in MI. Previous studies have shown that different variants of the methylene tetrahydrofolate reductase (MTHFR) gene are involved in causing MI by altering the metabolism of folate and homocysteine. However, the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor still needs to be investigated. This study recruited 300 participants who were divided into three groups, i.e., the control, MI, and MI-DM. The blood samples collected from the study participants were subjected to various biochemical tests and their clinical parameters were monitored. MTHFR C677T (rs1801133) genotyping was performed by Tetra ARMS PCR using predetermined primers. The MTHFR C677T (rs1801133) polymorphism was associated with MI in the presence of DM as a risk factor among the participants. The MTHFR C677T (rs1801133) T/T homozygous genotype was found to be significant among MI patients in the presence of DM as a risk factor.
Related Topics
Concepts
Methylenetetrahydrofolate reductase
Medicine
Myocardial infarction
Internal medicine
Homocysteine
Genotyping
Diabetes mellitus
Risk factor
Genotype
Single-nucleotide polymorphism
Gastroenterology
Cardiology
Endocrinology
Genetics
Biology
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/metabo13020251
- https://www.mdpi.com/2218-1989/13/2/251/pdf?version=1675941476
- OA Status
- gold
- Cited By
- 11
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4319981989
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4319981989Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/metabo13020251Digital Object Identifier
- Title
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Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk FactorWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-02-09Full publication date if available
- Authors
-
Tauqeer Hussain Mallhi, Momina Shahid, Kanwal Rehman, Yusra Habib Khan, Abdullah Salah Alanazi, Nasser Hadal Alotaibi, Muhammad Sajid Hamid Akash, Muhammad Hammad ButtList of authors in order
- Landing page
-
https://doi.org/10.3390/metabo13020251Publisher landing page
- PDF URL
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https://www.mdpi.com/2218-1989/13/2/251/pdf?version=1675941476Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2218-1989/13/2/251/pdf?version=1675941476Direct OA link when available
- Concepts
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Methylenetetrahydrofolate reductase, Medicine, Myocardial infarction, Internal medicine, Homocysteine, Genotyping, Diabetes mellitus, Risk factor, Genotype, Single-nucleotide polymorphism, Gastroenterology, Cardiology, Endocrinology, Genetics, Biology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 6, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
64Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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