Biochemical determinants of thrombin generation in a general population with arterial and venous disease background Article Swipe
Pauline C.S. van Paridon
,
Marina Panova‐Noeva
,
René van Oerle
,
Andreas Schulz
,
Jürgen H. Prochaska
,
Natalie Arnold
,
Irene Schmidtmann
,
Manfred E. Beutel
,
Norbert Pfeiffer
,
Thomas Münzel
,
Karl J. Lackner
,
Hugo Ten Cate
,
Philipp S. Wild
,
Henri M.H. Spronk
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1303017/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1303017/v1
Background: The current study aims to identify the biochemical determinants of plasma thrombin generation in a large population-based study by comparing individuals with a history of arterial or venous thrombosis to cardiovascular healthy individuals. Methods: This study comprised 502 individuals with a history of arterial disease, 195 with history of venous thrombosis and 1402 cardiovascular healthy individuals (reference sample) from the population-based Gutenberg Health Study (GHS). Calibrated Automated Thrombography was assessed and coagulation factors were measured by means of BCS XP Systems. To assess the biochemical determinants of TG variables, a multiple linear regression analysis, adjusted for age, sex and antithrombotic therapy, was conducted. Results: The lag time was mainly positively associated with the natural coagulant and anti-coagulant factors in the reference sample, i.e. higher factors result in a longer lag time. The same determinants were negative for individuals with a history of arterial or venous thrombosis, with a 10 times higher effect size. ETP was predominantly positively determined by factor II, VIII, X and IX in all subsamples. However, the effect sizes of the reported associations were 4 times higher for the arterial and venous subsamples in comparison to the reference sample. Conclusion: This large-scale analysis demonstrated a stronger effect of the coagulant and natural anti-coagulant factors on the thrombin potential in individuals with a history of arterial or venous thrombosis as compared to healthy individuals, which implicates sustained alterations in the plasma coagulome in subjects with a history of thrombotic vascular disease, despite intake of antithrombotic therapy.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-1303017/v1
- https://www.researchsquare.com/article/rs-1303017/latest.pdf
- OA Status
- green
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210863156
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4210863156Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-1303017/v1Digital Object Identifier
- Title
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Biochemical determinants of thrombin generation in a general population with arterial and venous disease backgroundWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-02-09Full publication date if available
- Authors
-
Pauline C.S. van Paridon, Marina Panova‐Noeva, René van Oerle, Andreas Schulz, Jürgen H. Prochaska, Natalie Arnold, Irene Schmidtmann, Manfred E. Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J. Lackner, Hugo Ten Cate, Philipp S. Wild, Henri M.H. SpronkList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-1303017/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-1303017/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-1303017/latest.pdfDirect OA link when available
- Concepts
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Antithrombotic, Medicine, Venous thrombosis, Thrombosis, Population, Internal medicine, Coagulation, Cardiology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
- References (count)
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18Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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