Bioengineering of the Optimized Biosynthesis of Commercially Vital Carotenoids- Techno-Advanced Applications Article Swipe
Ishrat Perveen
,
Naaz Abbas
,
Bakhtawar Bukhari
,
Yasar Saleem
,
Sania Mazhar
,
Shaista Nawaz
,
Quratulain Syed
,
Syed Hussain Imam Abidi
,
Sana Riaz
,
Fatima Akram
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.54393/pbmj.v6i12.995
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.54393/pbmj.v6i12.995
Beta-carotene, a carotenoid found in plants, fungi, and algae, is a crucial antioxidant and anti-cancer agent. It is primarily derived from plants, algae, and microbes, but this method has drawbacks like high costs and low productivity. The growing demand for carotenoids has led to large-scale industrial manufacturing. However, extracting and synthesizing these chemicals can be costly and technical. Microbial synthesis offers a cost-effective alternative. Synthetic biology and metabolic engineering technologies have been used in various studies for the optimization of pathways for the overproduction of carotenoids. Four metabolic components are involved in carotenoid biosynthesis, central carbon (C), isoprene supplement, and cofactor metabolism. Metabolic engineering is a potential solution to enhance β-carotene production. This article explores the biochemical routes, methods used by natural microbial species, and metabolic engineering potential of microbial organisms for β-carotenoids production. Currently, Escherichia coli, certain euglena and yeast species are the primary microorganisms used in metabolic engineering, offering minimal environmental impact, cost-effective manufacturing, and high yield.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.54393/pbmj.v6i12.995
- https://pakistanbmj.com/journal/index.php/pbmj/article/download/995/751
- OA Status
- diamond
- Cited By
- 1
- References
- 88
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390651080
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390651080Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.54393/pbmj.v6i12.995Digital Object Identifier
- Title
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Bioengineering of the Optimized Biosynthesis of Commercially Vital Carotenoids- Techno-Advanced ApplicationsWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-31Full publication date if available
- Authors
-
Ishrat Perveen, Naaz Abbas, Bakhtawar Bukhari, Yasar Saleem, Sania Mazhar, Shaista Nawaz, Quratulain Syed, Syed Hussain Imam Abidi, Sana Riaz, Fatima AkramList of authors in order
- Landing page
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https://doi.org/10.54393/pbmj.v6i12.995Publisher landing page
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https://pakistanbmj.com/journal/index.php/pbmj/article/download/995/751Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://pakistanbmj.com/journal/index.php/pbmj/article/download/995/751Direct OA link when available
- Concepts
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Metabolic engineering, Carotenoid, Bioprocess, Biology, Microorganism, Synthetic biology, Biotechnology, Yeast, Biochemistry, Biochemical engineering, Bacteria, Engineering, Computational biology, Enzyme, Genetics, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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88Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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