Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides Article Swipe
Hamada Saad
,
Thomas Majer
,
Keshab Bhattarai
,
Sarah Lampe
,
Dinh Thanh Nguyen
,
Markus Krämer
,
Jan Straetener
,
Heike Brötz‐Oesterhelt
,
Douglas A. Mitchell
,
Harald Gross
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.03.06.531328
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.03.06.531328
Lasso peptides are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) that feature an isopeptide bond and a distinct lariat fold. A growing number of secondary modifications have been described that further decorate lasso peptide scaffolds. Using genome mining, we have discovered a pair of lasso peptide biosynthetic gene clusters (BGCs) that include cytochrome P450 genes. Here, we report the structural characterization of two unique examples of (C-N) biaryl-containing lasso peptides. Nocapeptin A, from Nocardia terpenica, is tailored with Trp-Tyr crosslink while longipepetin A, from Longimycelium tulufanense, features Trp-Trp linkage. Besides the unusual bicyclic frame, longipepetin A receives an S-methylation by a new Met methyltransferase resulting in unprecedented sulfonium-bearing RiPP. Our bioinformatic survey revealed P450(s) and further maturating enzyme(s)-containing lasso BGCs awaiting future characterization.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.03.06.531328
- https://www.biorxiv.org/content/biorxiv/early/2023/03/06/2023.03.06.531328.full.pdf
- OA Status
- green
- Cited By
- 3
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4323663031
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4323663031Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.03.06.531328Digital Object Identifier
- Title
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Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso PeptidesWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-06Full publication date if available
- Authors
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Hamada Saad, Thomas Majer, Keshab Bhattarai, Sarah Lampe, Dinh Thanh Nguyen, Markus Krämer, Jan Straetener, Heike Brötz‐Oesterhelt, Douglas A. Mitchell, Harald GrossList of authors in order
- Landing page
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https://doi.org/10.1101/2023.03.06.531328Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2023/03/06/2023.03.06.531328.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2023/03/06/2023.03.06.531328.full.pdfDirect OA link when available
- Concepts
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Lasso (programming language), Computational biology, Drug discovery, Computer science, Bioinformatics, Chemistry, Biology, World Wide WebTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2024: 1, 2023: 2Per-year citation counts (last 5 years)
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49Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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