Bioinformatics screening and verification of ischemic stroke-related key genes and drug prediction Article Swipe
Shuai Jiang
,
Zhanhui Liu
,
Xianzhong Zhang
,
Rui Zhang
,
Bo Sun
,
Chao Gao
,
Pengfei Hou
,
Meirong Sun
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4149/gpb_2024023
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4149/gpb_2024023
Stroke is one of the major causes of disability and death worldwide. The lack of effective medical treatment for stroke heightens the need for new therapeutic targets. In this study, we obtained two microarray data sets from the Gene Expression Omnibus (GEO) database and identified differential genes (DEGs) between MCAO and control groups. Then, enrichment analysis of the DEGs was performed using DAVID and Metascape. The results show 27 DEGs shared between the two datasets. The functional enrichment analysis showed that these genes are mainly enriched in immune response, complement and coagulation cascades, apoptotic processes. The four hub genes (C1qc, Fcgr2b, C1qb, and Cd14) were screened out using the Cytoscape. Next, real-time PCR and Western blot analysis showed that expression of C1q and CD14 increased at 14 days after tMCAO. Furthermore, we took eight small molecule compounds with the lowest score using Cmap and studied their background characteristics. These results are built on a meta-analysis of data, which are generally accessible from the online space. Finally, we evaluated the protective effect of the rolipram through behavior tests after tMCAO, and results showed that the rolipram significantly attenuated neurobehavioral dysfunction at 14 days after brain ischemia. The present results provide novel insights into the biological process and potential therapeutic drugs involved in stroke.
Related Topics
Concepts
Stroke (engine)
Gene
Computational biology
Gene expression
Microarray
Microarray analysis techniques
Medicine
Bioinformatics
Biology
Genetics
Mechanical engineering
Engineering
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4149/gpb_2024023
- OA Status
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- Cited By
- 1
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401595841
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401595841Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4149/gpb_2024023Digital Object Identifier
- Title
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Bioinformatics screening and verification of ischemic stroke-related key genes and drug predictionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-01Full publication date if available
- Authors
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Shuai Jiang, Zhanhui Liu, Xianzhong Zhang, Rui Zhang, Bo Sun, Chao Gao, Pengfei Hou, Meirong SunList of authors in order
- Landing page
-
https://doi.org/10.4149/gpb_2024023Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.4149/gpb_2024023Direct OA link when available
- Concepts
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Stroke (engine), Gene, Computational biology, Gene expression, Microarray, Microarray analysis techniques, Medicine, Bioinformatics, Biology, Genetics, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- Related works (count)
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10Other works algorithmically related by OpenAlex
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