Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultraminimal-Invasive Biomarker Detection with Mechanical Robustness Article Swipe
Yilin Cai
,
Shiyi Huang
,
Zhinan Zhang
,
Jiazheng Zhang
,
Xingyue Zhu
,
Xiaoxiang Chen
,
Xianting Ding
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.34133/2022/9869734
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.34133/2022/9869734
Microneedle permits transdermal biosensing and drug delivery with minor pain. However, accurate microneedle transdermal positioning with minimal skin deformation remains a significant technical challenge due to inhomogeneous skin topology and discontinuous force applied to the microneedle. Here, we introduce bioinspired rotation microneedles for in vivo accurate microneedle positioning as inspired by honeybees’ stingers. We demonstrate the benefits of rotation microneedles in alleviating skin resistance through finite element analysis, full-thickness porcine validations, and mathematical derivations of microneedle-skin interaction stress fields. The max penetration force was mitigated by up to 45.7% and the force attenuation rate increased to 2.73 times in the holding stage after penetration. A decrease in max skin deflection and a faster deformation recovery introduced by rotation microneedles implied a more precise penetration depth. Furthermore, we applied the rotation microneedles in psoriasis mice, a monogenic disorder animal model, for minimally invasive biological sample extraction and proinflammatory cytokine monitoring. An ultrasensitive detection method is realized by using only one microneedle to achieve cytokine mRNA level determination compared to commonly required biopsies or blood collection. Thus, rotation microneedles permit a simple, rapid, and ultraminimal-invasive method for subcutaneous trace biological sample acquisition and subsequent point-of-care diagnostics with minimal damage to both microneedles and skins.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.34133/2022/9869734
- https://downloads.spj.sciencemag.org/research/2022/9869734.pdf
- OA Status
- gold
- Cited By
- 19
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4220711777
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4220711777Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.34133/2022/9869734Digital Object Identifier
- Title
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Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultraminimal-Invasive Biomarker Detection with Mechanical RobustnessWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-01Full publication date if available
- Authors
-
Yilin Cai, Shiyi Huang, Zhinan Zhang, Jiazheng Zhang, Xingyue Zhu, Xiaoxiang Chen, Xianting DingList of authors in order
- Landing page
-
https://doi.org/10.34133/2022/9869734Publisher landing page
- PDF URL
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https://downloads.spj.sciencemag.org/research/2022/9869734.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://downloads.spj.sciencemag.org/research/2022/9869734.pdfDirect OA link when available
- Concepts
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Transdermal, Materials science, Biomedical engineering, Penetration (warfare), Medicine, Mathematics, Pharmacology, Operations researchTop concepts (fields/topics) attached by OpenAlex
- Cited by
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19Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 5, 2023: 7, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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51Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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