Biological sex, sex steroids and sex chromosomes contribute to mouse cardiac aging Article Swipe
Audrey Morin-Grandmont
,
Élisabeth Walsh‐Wilkinson
,
Emylie-Ann Labbé
,
Sara-Ève Thibodeau
,
É. Dupont
,
Dominique K. Boudreau
,
Marie Arsenault
,
Yohan Bossé
,
Jacques Couët
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.18632/aging.205822
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.18632/aging.205822
After menopause, the incidence of cardiovascular disease rapidly rises in women. The disappearing protection provided by sex steroids is a consequence of the development of many risk factors. Preclinical studies are necessary to understand better the effects of ovarian hormones loss cardiac aging. To mimic menopause in mice and study its consequences, we delayed ovariectomy at 12 months and followed animals for 12 months. Using RNA sequencing, we investigated changes in the myocardial exome with aging. In addition, with four-core genotypes (FCG) transgenic mice, we studied sex chromosome effects on cardiac aging. Heart weight increased from 3 to 24 months (males + 35%, females + 29%). In males, 75% of this increase had occurred at 12 months; in females, only 30%. Gonadectomy of mice at 12 months blocked cardiac hypertrophy in both sexes during the second year of life. The dosage of the X chromosomes did not influence cardiac growth in young and older mice. We performed an RNA sequencing study in young and old mice. We identified new highly expressed genes modulated during aging (Bdh, Myot, Cpxm2, and Slc38a1). The myocardial exome in older animals displayed few differences related to the animal's sex or the presence or absence of sex steroids for a year. We show that the morphological evolution of the heart depends on the biological sex via gonadal sex hormone actions. The myocardial exome of old male and female mice is relatively similar. Our study emphasizes the need to consider sex steroid effects in studying cardiac aging.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/aging.205822
- https://www.aging-us.com/article/205822/pdf
- OA Status
- hybrid
- Cited By
- 4
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396855351
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396855351Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.18632/aging.205822Digital Object Identifier
- Title
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Biological sex, sex steroids and sex chromosomes contribute to mouse cardiac agingWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-13Full publication date if available
- Authors
-
Audrey Morin-Grandmont, Élisabeth Walsh‐Wilkinson, Emylie-Ann Labbé, Sara-Ève Thibodeau, É. Dupont, Dominique K. Boudreau, Marie Arsenault, Yohan Bossé, Jacques CouëtList of authors in order
- Landing page
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https://doi.org/10.18632/aging.205822Publisher landing page
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https://www.aging-us.com/article/205822/pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.aging-us.com/article/205822/pdfDirect OA link when available
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Biological sex, Biology, Sexual differentiation, Physiology, Genetics, Psychology, Developmental psychology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
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53Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.sex | 16, 86, 193, 200, 218, 221, 243 |
| abstract_inverted_index.the | 2, 22, 35, 71, 134, 142, 191, 195, 208, 212, 216, 239 |
| abstract_inverted_index.via | 219 |
| abstract_inverted_index.30%. | 120 |
| abstract_inverted_index.35%, | 102 |
| abstract_inverted_index.both | 131 |
| abstract_inverted_index.from | 95 |
| abstract_inverted_index.loss | 40 |
| abstract_inverted_index.male | 229 |
| abstract_inverted_index.many | 25 |
| abstract_inverted_index.mice | 47, 123, 232 |
| abstract_inverted_index.need | 240 |
| abstract_inverted_index.only | 119 |
| abstract_inverted_index.risk | 26 |
| abstract_inverted_index.show | 206 |
| abstract_inverted_index.that | 207 |
| abstract_inverted_index.this | 110 |
| abstract_inverted_index.with | 74, 78 |
| abstract_inverted_index.year | 136 |
| abstract_inverted_index.(FCG) | 81 |
| abstract_inverted_index.29%). | 105 |
| abstract_inverted_index.After | 0 |
| abstract_inverted_index.Heart | 92 |
| abstract_inverted_index.Using | 64 |
| abstract_inverted_index.aging | 174 |
| abstract_inverted_index.exome | 73, 182, 226 |
| abstract_inverted_index.genes | 171 |
| abstract_inverted_index.heart | 213 |
| abstract_inverted_index.life. | 138 |
| abstract_inverted_index.mice, | 83 |
| abstract_inverted_index.mice. | 154, 165 |
| abstract_inverted_index.mimic | 44 |
| abstract_inverted_index.older | 153, 184 |
| abstract_inverted_index.rises | 8 |
| abstract_inverted_index.sexes | 132 |
| abstract_inverted_index.study | 49, 160, 237 |
| abstract_inverted_index.year. | 204 |
| abstract_inverted_index.young | 151, 162 |
| abstract_inverted_index.(males | 100 |
| abstract_inverted_index.aging. | 42, 75, 91, 249 |
| abstract_inverted_index.better | 34 |
| abstract_inverted_index.dosage | 140 |
| abstract_inverted_index.during | 133, 173 |
| abstract_inverted_index.female | 231 |
| abstract_inverted_index.growth | 149 |
| abstract_inverted_index.highly | 169 |
| abstract_inverted_index.males, | 107 |
| abstract_inverted_index.months | 57, 99, 126 |
| abstract_inverted_index.second | 135 |
| abstract_inverted_index.weight | 93 |
| abstract_inverted_index.women. | 10 |
| abstract_inverted_index.absence | 198 |
| abstract_inverted_index.animals | 60, 185 |
| abstract_inverted_index.blocked | 127 |
| abstract_inverted_index.cardiac | 41, 90, 128, 148, 248 |
| abstract_inverted_index.changes | 69 |
| abstract_inverted_index.delayed | 53 |
| abstract_inverted_index.depends | 214 |
| abstract_inverted_index.disease | 6 |
| abstract_inverted_index.effects | 36, 88, 245 |
| abstract_inverted_index.females | 103 |
| abstract_inverted_index.gonadal | 220 |
| abstract_inverted_index.hormone | 222 |
| abstract_inverted_index.months. | 63 |
| abstract_inverted_index.months; | 116 |
| abstract_inverted_index.ovarian | 38 |
| abstract_inverted_index.rapidly | 7 |
| abstract_inverted_index.related | 189 |
| abstract_inverted_index.steroid | 244 |
| abstract_inverted_index.studied | 85 |
| abstract_inverted_index.studies | 29 |
| abstract_inverted_index.<i>Myot, | 176 |
| abstract_inverted_index.actions. | 223 |
| abstract_inverted_index.animal's | 192 |
| abstract_inverted_index.consider | 242 |
| abstract_inverted_index.factors. | 27 |
| abstract_inverted_index.females, | 118 |
| abstract_inverted_index.followed | 59 |
| abstract_inverted_index.hormones | 39 |
| abstract_inverted_index.increase | 111 |
| abstract_inverted_index.occurred | 113 |
| abstract_inverted_index.presence | 196 |
| abstract_inverted_index.provided | 14 |
| abstract_inverted_index.similar. | 235 |
| abstract_inverted_index.steroids | 17, 201 |
| abstract_inverted_index.studying | 247 |
| abstract_inverted_index.addition, | 77 |
| abstract_inverted_index.displayed | 186 |
| abstract_inverted_index.evolution | 210 |
| abstract_inverted_index.expressed | 170 |
| abstract_inverted_index.four-core | 79 |
| abstract_inverted_index.genotypes | 80 |
| abstract_inverted_index.incidence | 3 |
| abstract_inverted_index.increased | 94 |
| abstract_inverted_index.influence | 147 |
| abstract_inverted_index.menopause | 45 |
| abstract_inverted_index.modulated | 172 |
| abstract_inverted_index.necessary | 31 |
| abstract_inverted_index.performed | 156 |
| abstract_inverted_index.Cpxm2</i>, | 177 |
| abstract_inverted_index.biological | 217 |
| abstract_inverted_index.chromosome | 87 |
| abstract_inverted_index.emphasizes | 238 |
| abstract_inverted_index.identified | 167 |
| abstract_inverted_index.menopause, | 1 |
| abstract_inverted_index.myocardial | 72, 181, 225 |
| abstract_inverted_index.protection | 13 |
| abstract_inverted_index.relatively | 234 |
| abstract_inverted_index.sequencing | 159 |
| abstract_inverted_index.transgenic | 82 |
| abstract_inverted_index.understand | 33 |
| abstract_inverted_index.Gonadectomy | 121 |
| abstract_inverted_index.Preclinical | 28 |
| abstract_inverted_index.chromosomes | 144 |
| abstract_inverted_index.consequence | 20 |
| abstract_inverted_index.development | 23 |
| abstract_inverted_index.differences | 188 |
| abstract_inverted_index.hypertrophy | 129 |
| abstract_inverted_index.ovariectomy | 54 |
| abstract_inverted_index.sequencing, | 66 |
| abstract_inverted_index.(<i>Bdh</i>, | 175 |
| abstract_inverted_index.disappearing | 12 |
| abstract_inverted_index.investigated | 68 |
| abstract_inverted_index.consequences, | 51 |
| abstract_inverted_index.morphological | 209 |
| abstract_inverted_index.cardiovascular | 5 |
| abstract_inverted_index.<i>Slc38a1</i>). | 179 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5068759897 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.6100000143051147 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.84774924 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |