Biomarker-based treatment stratification in ADHD: An out-of-sample validation Article Swipe

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Helena Voetterl , Guido van Wingen , Giorgia Michelini , Kristi R. Griffiths , Evian Gordon , Roger deBeus , Mayuresh S. Korgaonkar , Sandra K. Loo , Donna Palmer , Rien Breteler , Damiaan Denys , Eugene Arnold , Paul du Jour , Rosalinde van Ruth , Jeanine Jansen , Hanneke van Dijk , Martijn Arns ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.21203/rs.3.rs-736917/v1

Attention-deficit/hyperactivity disorder (ADHD) is characterized by neurobiological heterogeneity, possibly explaining why not all patients benefit from a given treatment. As a means to select the right treatment (stratification), biomarkers may aid in personalizing treatment prescription, thereby increasing remission rates.The present study introduces a clinically interpretable and actionable, age- and sex-standardized biomarker based on individual alpha peak frequency (iAPF) assessed during resting-state electroencephalography (EEG). The biomarker was developed in a heterogeneous sample (N=4249), and stratifies patients with a higher iAPF to Methylphenidate (MPH; N=336) and those with a lower iAPF to Neurofeedback (NFB; N=136), resulting in a predicted gain in normalized remission of 17-30%. Blinded out-of-sample validation studies for MPH (N=58) and NFB (N=96) corroborated these findings, yielding a predicted gain in stratified normalized remission of 36% and 29%, respectively.These findings suggest that acknowledging neurobiological heterogeneity can inform stratification of patients to their individual best treatment and enhance remission rates.

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Environmental Science

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Biomarker Stratification (seeds) Risk stratification Sample (material) Environmental science Psychology Oncology Medicine Internal medicine Biology Chromatography Chemistry Genetics Seed dormancy Dormancy Germination Botany

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Type: preprint
Language: en
Landing Page: https://doi.org/10.21203/rs.3.rs-736917/v1
PDF: https://www.researchsquare.com/article/rs-736917/latest.pdf
OA Status: gold
Cited By: 1
References: 39
Related Works: 10
OpenAlex ID: https://openalex.org/W3198572533

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DOI: https://doi.org/10.21203/rs.3.rs-736917/v1

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Title: Biomarker-based treatment stratification in ADHD: An out-of-sample validation

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Type: preprint

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Language: en

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Publication year: 2021

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Publication date: 2021-08-26

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Authors: Helena Voetterl, Guido van Wingen, Giorgia Michelini, Kristi R. Griffiths, Evian Gordon, Roger deBeus, Mayuresh S. Korgaonkar, Sandra K. Loo, Donna Palmer, Rien Breteler, Damiaan Denys, Eugene Arnold, Paul du Jour, Rosalinde van Ruth, Jeanine Jansen, Hanneke van Dijk, Martijn Arns

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Landing page: https://doi.org/10.21203/rs.3.rs-736917/v1

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PDF URL: https://www.researchsquare.com/article/rs-736917/latest.pdf

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Concepts: Biomarker, Stratification (seeds), Risk stratification, Sample (material), Environmental science, Psychology, Oncology, Medicine, Internal medicine, Biology, Chromatography, Chemistry, Genetics, Seed dormancy, Dormancy, Germination, Botany

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Cited by: 1

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