Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus Article Swipe
James Greenan-Barrett
,
Georgia Doolan
,
Devina Shah
,
Simrun Virdee
,
George Robinson
,
Varvara Choida
,
Nataliya Gak
,
Nina de Gruijter
,
Elizabeth C. Rosser
,
Muthana Al-Obaidi
,
Maria Leandro
,
Michael S. Zandi
,
Ruth J. Pepper
,
Alan D. Salama
,
Elizabeth C. Jury
,
Coziana Ciurtin
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms22147619
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms22147619
Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, identifying biomarkers associated with the disease pathogenesis and reflecting particularities of JSLE clinical phenotype holds promise for better patient management and improved outcomes. This narrative review summarises the evidence related to various traditional and novel biomarkers that have shown a promising role in identifying and predicting specific organ involvement in JSLE and appraises the evidence regarding their clinical utility, focusing in particular on renal biomarkers, while also emphasising the research into cardiovascular, haematological, neurological, skin and joint disease-related JSLE biomarkers, as well as genetic biomarkers with potential clinical applications.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms22147619
- https://www.mdpi.com/1422-0067/22/14/7619/pdf?version=1626679673
- OA Status
- gold
- Cited By
- 20
- References
- 267
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3184988497
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3184988497Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms22147619Digital Object Identifier
- Title
-
Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus ErythematosusWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-16Full publication date if available
- Authors
-
James Greenan-Barrett, Georgia Doolan, Devina Shah, Simrun Virdee, George Robinson, Varvara Choida, Nataliya Gak, Nina de Gruijter, Elizabeth C. Rosser, Muthana Al-Obaidi, Maria Leandro, Michael S. Zandi, Ruth J. Pepper, Alan D. Salama, Elizabeth C. Jury, Coziana CiurtinList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms22147619Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/22/14/7619/pdf?version=1626679673Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/22/14/7619/pdf?version=1626679673Direct OA link when available
- Concepts
-
Medicine, Disease, Systemic lupus erythematosus, Age of onset, Juvenile, Systemic disease, Clinical phenotype, Immunology, Phenotype, Intensive care medicine, Pathology, Biology, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 4, 2023: 9, 2022: 4Per-year citation counts (last 5 years)
- References (count)
-
267Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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