Biomarkers of cellular senescence and risk of death in humans Article Swipe
Jennifer L. St. Sauver
,
Susan A. Weston
,
Elizabeth J. Atkinson
,
Michaela E. Mc Gree
,
Michelle M. Mielke
,
Thomas A. White
,
Amanda A. Heeren
,
Janet E. Olson
,
Walter A. Rocca
,
Allyson K. Palmer
,
Steven R. Cummings
,
Roger A. Fielding
,
Suzette J. Bielinski
,
Nathan K. LeBrasseur
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/acel.14006
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/acel.14006
A robust and heterogenous secretory phenotype is a core feature of most senescent cells. In addition to mediators of age‐related pathology, components of the senescence associated secretory phenotype (SASP) have been studied as biomarkers of senescent cell burden and, in turn, biological age. Therefore, we hypothesized that circulating concentrations of candidate senescence biomarkers, including chemokines, cytokines, matrix remodeling proteins, and growth factors, could predict mortality in older adults. We assessed associations between plasma levels of 28 SASP proteins and risk of mortality over a median follow‐up of 6.3 years in 1923 patients 65 years of age or older with zero or one chronic condition at baseline. Overall, the five senescence biomarkers most strongly associated with an increased risk of death were GDF15, RAGE, VEGFA, PARC, and MMP2, after adjusting for age, sex, race, and the presence of one chronic condition. The combination of biomarkers and clinical and demographic covariates exhibited a significantly higher c‐statistic for risk of death (0.79, 95% confidence interval (CI): 0.76–0.82) than the covariates alone (0.70, CI: 0.67–0.74) ( p < 0.001). Collectively, these findings lend further support to biomarkers of cellular senescence as informative predictors of clinically important health outcomes in older adults, including death.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/acel.14006
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.14006
- OA Status
- gold
- Cited By
- 60
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387420605
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387420605Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/acel.14006Digital Object Identifier
- Title
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Biomarkers of cellular senescence and risk of death in humansWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-10-06Full publication date if available
- Authors
-
Jennifer L. St. Sauver, Susan A. Weston, Elizabeth J. Atkinson, Michaela E. Mc Gree, Michelle M. Mielke, Thomas A. White, Amanda A. Heeren, Janet E. Olson, Walter A. Rocca, Allyson K. Palmer, Steven R. Cummings, Roger A. Fielding, Suzette J. Bielinski, Nathan K. LeBrasseurList of authors in order
- Landing page
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https://doi.org/10.1111/acel.14006Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.14006Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.14006Direct OA link when available
- Concepts
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Senescence, Biology, Biomarker, Internal medicine, Disease, Confidence interval, Phenotype, Immunology, Bioinformatics, Oncology, Medicine, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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60Total citation count in OpenAlex
- Citations by year (recent)
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2025: 25, 2024: 30, 2023: 5Per-year citation counts (last 5 years)
- References (count)
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45Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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