Biomaterial Approaches to Modulate Reactive Astroglial Response Article Swipe
Jonathan M. Zuidema
,
Ryan J. Gilbert
,
Manoj K. Gottipati
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1159/000494667
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1159/000494667
Over several decades, biomaterial scientists have developed materials to spur axonal regeneration and limit secondary injury and tested these materials within preclinical animal models. Rarely, though, are astrocytes examined comprehensively when biomaterials are placed into the injury site. Astrocytes support neuronal function in the central nervous system. Following an injury, astrocytes undergo reactive gliosis and create a glial scar. The astrocytic glial scar forms a dense barrier which restricts the extension of regenerating axons through the injury site. However, there are several beneficial effects of the glial scar, including helping to reform the blood-brain barrier, limiting the extent of secondary injury, and supporting the health of regenerating axons near the injury site. This review provides a brief introduction to the role of astrocytes in the spinal cord, discusses astrocyte phenotypic changes that occur following injury, and highlights studies that explored astrocyte changes in response to biomaterials tested within in vitro or in vivo environments. Overall, we suggest that in order to improve biomaterial designs for spinal cord injury applications, investigators should more thoroughly consider the astrocyte response to such designs.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1159/000494667
- https://www.karger.com/Article/Pdf/494667
- OA Status
- bronze
- Cited By
- 42
- References
- 211
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2902346620
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2902346620Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1159/000494667Digital Object Identifier
- Title
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Biomaterial Approaches to Modulate Reactive Astroglial ResponseWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-01-01Full publication date if available
- Authors
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Jonathan M. Zuidema, Ryan J. Gilbert, Manoj K. GottipatiList of authors in order
- Landing page
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https://doi.org/10.1159/000494667Publisher landing page
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https://www.karger.com/Article/Pdf/494667Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.karger.com/Article/Pdf/494667Direct OA link when available
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Biomaterial, Neuroscience, Biology, Medicine, Biomedical engineeringTop concepts (fields/topics) attached by OpenAlex
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42Total citation count in OpenAlex
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2025: 2, 2024: 6, 2023: 4, 2022: 8, 2021: 8Per-year citation counts (last 5 years)
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211Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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