Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development Article Swipe
Lingchi Kong
,
Xin Gao
,
Yun Qian
,
Wei Sun
,
Zhengwei You
,
Cunyi Fan
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7150/thno.74571
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7150/thno.74571
Peripheral nerve injury (PNI) caused by trauma, chronic disease and other factors may lead to partial or complete loss of sensory, motor and autonomic functions, as well as neuropathic pain. Biological activities are always accompanied by mechanical stimulation, and biomechanical microenvironmental homeostasis plays a complicated role in tissue repair and regeneration. Recent studies have focused on the effects of biomechanical microenvironment on peripheral nervous system development and function maintenance, as well as neural regrowth following PNI. For example, biomechanical factors-induced cluster gene expression changes contribute to formation of peripheral nerve structure and maintenance of physiological function. In addition, extracellular matrix and cell responses to biomechanical microenvironment alterations after PNI directly trigger a series of cascades for the well-organized peripheral nerve regeneration (PNR) process, where cell adhesion molecules, cytoskeletons and mechanically gated ion channels serve as mechanosensitive units, mechanical effector including focal adhesion kinase (FAK) and yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) as mechanotransduction elements. With the rapid development of tissue engineering techniques, a substantial number of PNR strategies such as aligned nerve guidance conduits, three-dimensional topological designs and piezoelectric scaffolds emerge expected to improve the neural biomechanical microenvironment in case of PNI. These tissue engineering nerve grafts display optimized mechanical properties and outstanding mechanomodulatory effects, but a few bottlenecks restrict their application scenes. In this review, the current understanding in biomechanical microenvironment homeostasis associated with peripheral nerve function and PNR is integrated, where we proposed the importance of balances of mechanosensitive elements, cytoskeletal structures, mechanotransduction cascades, and extracellular matrix components; a wide variety of promising tissue engineering strategies based on biomechanical modulation are introduced with some suggestions and prospects for future directions.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.7150/thno.74571
- https://www.thno.org/v12p4993.pdf
- OA Status
- gold
- Cited By
- 71
- References
- 206
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285203303
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285203303Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7150/thno.74571Digital Object Identifier
- Title
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Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering developmentWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-01Full publication date if available
- Authors
-
Lingchi Kong, Xin Gao, Yun Qian, Wei Sun, Zhengwei You, Cunyi FanList of authors in order
- Landing page
-
https://doi.org/10.7150/thno.74571Publisher landing page
- PDF URL
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https://www.thno.org/v12p4993.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.thno.org/v12p4993.pdfDirect OA link when available
- Concepts
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Mechanotransduction, Mechanosensitive channels, Extracellular matrix, Cell biology, Neuroscience, Regeneration (biology), Tissue engineering, Nerve injury, Chemistry, Anatomy, Biology, Medicine, Biomedical engineering, Ion channel, Receptor, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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71Total citation count in OpenAlex
- Citations by year (recent)
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2025: 29, 2024: 26, 2023: 16Per-year citation counts (last 5 years)
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206Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.tissue | 47, 161, 195, 257 |
| abstract_inverted_index.units, | 136 |
| abstract_inverted_index.aligned | 172 |
| abstract_inverted_index.changes | 83 |
| abstract_inverted_index.chronic | 7 |
| abstract_inverted_index.cluster | 80 |
| abstract_inverted_index.current | 219 |
| abstract_inverted_index.designs | 178 |
| abstract_inverted_index.disease | 8 |
| abstract_inverted_index.display | 199 |
| abstract_inverted_index.effects | 57 |
| abstract_inverted_index.factors | 11 |
| abstract_inverted_index.focused | 54 |
| abstract_inverted_index.improve | 185 |
| abstract_inverted_index.nervous | 63 |
| abstract_inverted_index.partial | 15 |
| abstract_inverted_index.protein | 146 |
| abstract_inverted_index.review, | 217 |
| abstract_inverted_index.scenes. | 214 |
| abstract_inverted_index.studies | 52 |
| abstract_inverted_index.trauma, | 6 |
| abstract_inverted_index.trigger | 110 |
| abstract_inverted_index.variety | 254 |
| abstract_inverted_index.adhesion | 125, 141 |
| abstract_inverted_index.balances | 240 |
| abstract_inverted_index.cascades | 114 |
| abstract_inverted_index.channels | 132 |
| abstract_inverted_index.complete | 17 |
| abstract_inverted_index.directly | 109 |
| abstract_inverted_index.effector | 138 |
| abstract_inverted_index.effects, | 206 |
| abstract_inverted_index.example, | 77 |
| abstract_inverted_index.expected | 183 |
| abstract_inverted_index.function | 67, 229 |
| abstract_inverted_index.guidance | 174 |
| abstract_inverted_index.process, | 122 |
| abstract_inverted_index.proposed | 236 |
| abstract_inverted_index.regrowth | 73 |
| abstract_inverted_index.restrict | 211 |
| abstract_inverted_index.sensory, | 20 |
| abstract_inverted_index.addition, | 97 |
| abstract_inverted_index.autonomic | 23 |
| abstract_inverted_index.cascades, | 247 |
| abstract_inverted_index.conduits, | 175 |
| abstract_inverted_index.elements, | 243 |
| abstract_inverted_index.elements. | 155 |
| abstract_inverted_index.following | 74 |
| abstract_inverted_index.formation | 86 |
| abstract_inverted_index.function. | 95 |
| abstract_inverted_index.including | 139 |
| abstract_inverted_index.optimized | 200 |
| abstract_inverted_index.promising | 256 |
| abstract_inverted_index.prospects | 270 |
| abstract_inverted_index.responses | 102 |
| abstract_inverted_index.scaffolds | 181 |
| abstract_inverted_index.structure | 90 |
| abstract_inverted_index.Biological | 30 |
| abstract_inverted_index.Peripheral | 0 |
| abstract_inverted_index.activities | 31 |
| abstract_inverted_index.associated | 225 |
| abstract_inverted_index.contribute | 84 |
| abstract_inverted_index.expression | 82 |
| abstract_inverted_index.functions, | 24 |
| abstract_inverted_index.importance | 238 |
| abstract_inverted_index.introduced | 265 |
| abstract_inverted_index.mechanical | 36, 137, 201 |
| abstract_inverted_index.modulation | 263 |
| abstract_inverted_index.molecules, | 126 |
| abstract_inverted_index.peripheral | 62, 88, 118, 227 |
| abstract_inverted_index.properties | 202 |
| abstract_inverted_index.strategies | 169, 259 |
| abstract_inverted_index.PDZ-binding | 150 |
| abstract_inverted_index.accompanied | 34 |
| abstract_inverted_index.alterations | 106 |
| abstract_inverted_index.application | 213 |
| abstract_inverted_index.bottlenecks | 210 |
| abstract_inverted_index.coactivator | 148 |
| abstract_inverted_index.complicated | 44 |
| abstract_inverted_index.components; | 251 |
| abstract_inverted_index.development | 65, 159 |
| abstract_inverted_index.directions. | 273 |
| abstract_inverted_index.engineering | 162, 196, 258 |
| abstract_inverted_index.homeostasis | 41, 224 |
| abstract_inverted_index.integrated, | 233 |
| abstract_inverted_index.maintenance | 92 |
| abstract_inverted_index.neuropathic | 28 |
| abstract_inverted_index.outstanding | 204 |
| abstract_inverted_index.structures, | 245 |
| abstract_inverted_index.substantial | 165 |
| abstract_inverted_index.suggestions | 268 |
| abstract_inverted_index.techniques, | 163 |
| abstract_inverted_index.topological | 177 |
| abstract_inverted_index.cytoskeletal | 244 |
| abstract_inverted_index.maintenance, | 68 |
| abstract_inverted_index.mechanically | 129 |
| abstract_inverted_index.regeneration | 120 |
| abstract_inverted_index.stimulation, | 37 |
| abstract_inverted_index.biomechanical | 39, 59, 78, 104, 188, 222, 262 |
| abstract_inverted_index.cytoskeletons | 127 |
| abstract_inverted_index.extracellular | 98, 249 |
| abstract_inverted_index.physiological | 94 |
| abstract_inverted_index.piezoelectric | 180 |
| abstract_inverted_index.regeneration. | 50 |
| abstract_inverted_index.understanding | 220 |
| abstract_inverted_index.well-organized | 117 |
| abstract_inverted_index.yes-associated | 145 |
| abstract_inverted_index.factors-induced | 79 |
| abstract_inverted_index.mechanosensitive | 135, 242 |
| abstract_inverted_index.microenvironment | 60, 105, 189, 223 |
| abstract_inverted_index.mechanomodulatory | 205 |
| abstract_inverted_index.three-dimensional | 176 |
| abstract_inverted_index.microenvironmental | 40 |
| abstract_inverted_index.mechanotransduction | 154, 246 |
| abstract_inverted_index.(YAP)/transcriptional | 147 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 99 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6700000166893005 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.98896634 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |