Biomimetic Nanoparticles Loaded With α‐Cyperone Alleviating LPS‐Induced Inflammation in KGN Cells by Activating Nrf2/HO‐1 and Suppressing ROS

Exploring foci of: Journal of Biochemical and Molecular Toxicology • Vol 39 • No 9 Biomimetic Nanoparticles Loaded With α‐Cyperone Alleviating LPS‐Induced Inflammation in KGN Cells by Activating Nrf2/HO‐1 and Suppressing ROS September 2025 • Jialing Li, Fengzhi Li, Xue Chen, Jie Ma, Hua Guo ABSTRACT Diminished ovarian reserve (DOR) is a leading cause of female infertility, and currently, no effective therapeutic options are available. α‐Cyperone (AC) possesses various pharmacological properties, including anti‐inflammatory and antioxidant effects. However, its clinical application is hindered by poor water solubility, a short half‐life, and nonspecific toxicity. In this study, we utilized nanotechnology to develop a novel dual‐targeted nanocomplex, termed PLGA@AC@FSHL‐M (PAMF) nanoparticles (NPs), co… Open Article Page

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