Biomimetic Proteoglycans for Intervertebral Disc (IVD) Regeneration Article Swipe
Neha Chopra
,
James Melrose
,
Zi Gu
,
Ashish D. Diwan
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomimetics9120722
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomimetics9120722
Intervertebral disc degeneration, which leads to low back pain, is the most prevalent musculoskeletal condition worldwide, significantly impairing quality of life and imposing substantial socioeconomic burdens on affected individuals. A major impediment to the development of any prospective cell-driven recovery of functional properties in degenerate IVDs is the diminishing IVD cell numbers and viability with ageing which cannot sustain such a recovery process. However, if IVD proteoglycan levels, a major functional component, can be replenished through an orthobiological process which does not rely on cellular or nutritional input, then this may be an effective strategy for the re-attainment of IVD mechanical properties. Furthermore, biomimetic proteoglycans (PGs) represent an established polymer that strengthens osteoarthritis cartilage and improves its biomechanical properties, actively promoting biological repair processes. Biomimetic PGs have superior water imbibing properties compared to native aggrecan and are more resistant to proteolytic degradation, increasing their biological half-life in cartilaginous tissues. Methods have also now been developed to chemically edit the structure of biomimetic proteoglycans, allowing for the incorporation of bioactive peptide modules and equipping biomimetic proteoglycans as delivery vehicles for drugs and growth factors, further improving their biotherapeutic credentials. This article aims to provide a comprehensive overview of prospective orthobiological strategies that leverage engineered proteoglycans, paving the way for novel therapeutic interventions in IVD degeneration and ultimately enhancing patient outcomes.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomimetics9120722
- https://www.mdpi.com/2313-7673/9/12/722/pdf?version=1732279614
- OA Status
- gold
- Cited By
- 4
- References
- 143
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404638898
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4404638898Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomimetics9120722Digital Object Identifier
- Title
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Biomimetic Proteoglycans for Intervertebral Disc (IVD) RegenerationWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-22Full publication date if available
- Authors
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Neha Chopra, James Melrose, Zi Gu, Ashish D. DiwanList of authors in order
- Landing page
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https://doi.org/10.3390/biomimetics9120722Publisher landing page
- PDF URL
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https://www.mdpi.com/2313-7673/9/12/722/pdf?version=1732279614Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2313-7673/9/12/722/pdf?version=1732279614Direct OA link when available
- Concepts
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Aggrecan, Intervertebral disc, Regeneration (biology), Cartilage, Proteoglycan, Osteoarthritis, Biomedical engineering, Cell biology, Medicine, Articular cartilage, Anatomy, Biology, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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143Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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