Bio‐Nano Innovations Targeting the Neurovascular Complex for Epilepsy Treatment Article Swipe
Xin Wang
,
Yikang Cheng
,
Zhenghan Qi
,
Jing Zhao
,
Cong Wang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202404857
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202404857
Epilepsy is a prevalent chronic neurological disorder characterized by seizures resulting from an imbalance between excitatory and inhibitory neurons. While pharmacotherapy remains the standard treatment, traditional pharmacotherapy faces significant challenges, including poor brain penetration, high drug resistance rates, and providing only symptomatic relief, rather than addressing the underlying causes for a comprehensive cure. Recently, the neurovascular complex (NVC) has gained attention for its critical role in the development and progression of epilepsy. Simultaneously, various innovative bio‐nanotechnology systems have emerged, specifically designed to enhance drug delivery across the brain and enable precise targeting within the lesion. Herein, this review begins by outlining the core NVC involved in epilepsy treatment, breaking it down into four key components: the blood‐brain barrier (BBB), neurons, glial cells, and the microenvironment. The viability of targeting NVC to improve epilepsy therapy is analyzed. Next, innovative bio‐nanotechnology systems, detailing their design principles, construction strategies, and preclinical evaluations in epilepsy therapy are highlighted. Finally, the prospects for next‐generation nanotechnologies and the challenges that must be overcome for effective clinical translation are discussed. Overall, this review aims to guide the development of more efficient and precise bio‐nano therapies, ultimately enhancing treatment outcomes for epilepsy patients.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/adhm.202404857
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202404857
- OA Status
- bronze
- References
- 181
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409966032
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4409966032Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/adhm.202404857Digital Object Identifier
- Title
-
Bio‐Nano Innovations Targeting the Neurovascular Complex for Epilepsy TreatmentWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-30Full publication date if available
- Authors
-
Xin Wang, Yikang Cheng, Zhenghan Qi, Jing Zhao, Cong WangList of authors in order
- Landing page
-
https://doi.org/10.1002/adhm.202404857Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202404857Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202404857Direct OA link when available
- Concepts
-
Epilepsy, Neurovascular bundle, Medicine, Neuroscience, Drug Resistant Epilepsy, Drug delivery, Intensive care medicine, Nanotechnology, Psychology, Pathology, Materials scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
181Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4409966032 |
|---|---|
| doi | https://doi.org/10.1002/adhm.202404857 |
| ids.doi | https://doi.org/10.1002/adhm.202404857 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40304157 |
| ids.openalex | https://openalex.org/W4409966032 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000188 |
| mesh[1].descriptor_ui | D004827 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | drug therapy |
| mesh[1].descriptor_name | Epilepsy |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D004827 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Epilepsy |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D001812 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Blood-Brain Barrier |
| mesh[4].qualifier_ui | Q000187 |
| mesh[4].descriptor_ui | D001812 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | drug effects |
| mesh[4].descriptor_name | Blood-Brain Barrier |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D000818 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Animals |
| mesh[6].qualifier_ui | Q000379 |
| mesh[6].descriptor_ui | D016503 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | methods |
| mesh[6].descriptor_name | Drug Delivery Systems |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D009474 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Neurons |
| mesh[8].qualifier_ui | Q000473 |
| mesh[8].descriptor_ui | D009474 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | pathology |
| mesh[8].descriptor_name | Neurons |
| mesh[9].qualifier_ui | Q000379 |
| mesh[9].descriptor_ui | D036103 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | methods |
| mesh[9].descriptor_name | Nanotechnology |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D009457 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Neuroglia |
| type | review |
| title | Bio‐Nano Innovations Targeting the Neurovascular Complex for Epilepsy Treatment |
| biblio.issue | 14 |
| biblio.volume | 14 |
| biblio.last_page | e2404857 |
| biblio.first_page | e2404857 |
| grants[0].funder | https://openalex.org/F4320321001 |
| grants[0].award_id | 82202224 |
| grants[0].funder_display_name | National Natural Science Foundation of China |
| grants[1].funder | https://openalex.org/F4320321001 |
| grants[1].award_id | 82472038 |
| grants[1].funder_display_name | National Natural Science Foundation of China |
| grants[2].funder | https://openalex.org/F4320327803 |
| grants[2].award_id | 23QA1407700 |
| grants[2].funder_display_name | Shanghai Rising-Star Program |
| grants[3].funder | https://openalex.org/F4320328940 |
| grants[3].award_id | 18DZ2260400 |
| grants[3].funder_display_name | Shanghai Key Laboratory of Molecular Imaging |
| grants[4].funder | https://openalex.org/F4320335777 |
| grants[4].award_id | 2023YFF0714200 |
| grants[4].funder_display_name | National Key Research and Development Program of China |
| topics[0].id | https://openalex.org/T10094 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2738 |
| topics[0].subfield.display_name | Psychiatry and Mental health |
| topics[0].display_name | Epilepsy research and treatment |
| topics[1].id | https://openalex.org/T10077 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9983999729156494 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2804 |
| topics[1].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[1].display_name | Neuroscience and Neuropharmacology Research |
| topics[2].id | https://openalex.org/T10063 |
| topics[2].field.id | https://openalex.org/fields/25 |
| topics[2].field.display_name | Materials Science |
| topics[2].score | 0.9977999925613403 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2502 |
| topics[2].subfield.display_name | Biomaterials |
| topics[2].display_name | Nanoparticle-Based Drug Delivery |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320327803 |
| funders[1].ror | |
| funders[1].display_name | Shanghai Rising-Star Program |
| funders[2].id | https://openalex.org/F4320328940 |
| funders[2].ror | |
| funders[2].display_name | Shanghai Key Laboratory of Molecular Imaging |
| funders[3].id | https://openalex.org/F4320335777 |
| funders[3].ror | |
| funders[3].display_name | National Key Research and Development Program of China |
| is_xpac | False |
| apc_list.value | 4430 |
| apc_list.currency | USD |
| apc_list.value_usd | 4430 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2778186239 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7491117715835571 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q41571 |
| concepts[0].display_name | Epilepsy |
| concepts[1].id | https://openalex.org/C105572291 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6453120112419128 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7002775 |
| concepts[1].display_name | Neurovascular bundle |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.5506288409233093 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C169760540 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5420551896095276 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[3].display_name | Neuroscience |
| concepts[4].id | https://openalex.org/C2910833928 |
| concepts[4].level | 3 |
| concepts[4].score | 0.4670041799545288 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q18975053 |
| concepts[4].display_name | Drug Resistant Epilepsy |
| concepts[5].id | https://openalex.org/C2779820397 |
| concepts[5].level | 2 |
| concepts[5].score | 0.41882622241973877 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q1392806 |
| concepts[5].display_name | Drug delivery |
| concepts[6].id | https://openalex.org/C177713679 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3491319417953491 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q679690 |
| concepts[6].display_name | Intensive care medicine |
| concepts[7].id | https://openalex.org/C171250308 |
| concepts[7].level | 1 |
| concepts[7].score | 0.27261245250701904 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11468 |
| concepts[7].display_name | Nanotechnology |
| concepts[8].id | https://openalex.org/C15744967 |
| concepts[8].level | 0 |
| concepts[8].score | 0.2005884349346161 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[8].display_name | Psychology |
| concepts[9].id | https://openalex.org/C142724271 |
| concepts[9].level | 1 |
| concepts[9].score | 0.11082205176353455 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[9].display_name | Pathology |
| concepts[10].id | https://openalex.org/C192562407 |
| concepts[10].level | 0 |
| concepts[10].score | 0.09445574879646301 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[10].display_name | Materials science |
| keywords[0].id | https://openalex.org/keywords/epilepsy |
| keywords[0].score | 0.7491117715835571 |
| keywords[0].display_name | Epilepsy |
| keywords[1].id | https://openalex.org/keywords/neurovascular-bundle |
| keywords[1].score | 0.6453120112419128 |
| keywords[1].display_name | Neurovascular bundle |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.5506288409233093 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/neuroscience |
| keywords[3].score | 0.5420551896095276 |
| keywords[3].display_name | Neuroscience |
| keywords[4].id | https://openalex.org/keywords/drug-resistant-epilepsy |
| keywords[4].score | 0.4670041799545288 |
| keywords[4].display_name | Drug Resistant Epilepsy |
| keywords[5].id | https://openalex.org/keywords/drug-delivery |
| keywords[5].score | 0.41882622241973877 |
| keywords[5].display_name | Drug delivery |
| keywords[6].id | https://openalex.org/keywords/intensive-care-medicine |
| keywords[6].score | 0.3491319417953491 |
| keywords[6].display_name | Intensive care medicine |
| keywords[7].id | https://openalex.org/keywords/nanotechnology |
| keywords[7].score | 0.27261245250701904 |
| keywords[7].display_name | Nanotechnology |
| keywords[8].id | https://openalex.org/keywords/psychology |
| keywords[8].score | 0.2005884349346161 |
| keywords[8].display_name | Psychology |
| keywords[9].id | https://openalex.org/keywords/pathology |
| keywords[9].score | 0.11082205176353455 |
| keywords[9].display_name | Pathology |
| keywords[10].id | https://openalex.org/keywords/materials-science |
| keywords[10].score | 0.09445574879646301 |
| keywords[10].display_name | Materials science |
| language | en |
| locations[0].id | doi:10.1002/adhm.202404857 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2500736452 |
| locations[0].source.issn | 2192-2640, 2192-2659 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 2192-2640 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Advanced Healthcare Materials |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202404857 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Advanced Healthcare Materials |
| locations[0].landing_page_url | https://doi.org/10.1002/adhm.202404857 |
| locations[1].id | pmid:40304157 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Advanced healthcare materials |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40304157 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5100328046 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9405-4485 |
| authorships[0].author.display_name | Xin Wang |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I24943067 |
| authorships[0].affiliations[0].raw_affiliation_string | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China |
| authorships[0].institutions[0].id | https://openalex.org/I24943067 |
| authorships[0].institutions[0].ror | https://ror.org/013q1eq08 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I24943067 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Fudan University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Xin Wang |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China |
| authorships[1].author.id | https://openalex.org/A5016999352 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-4942-3904 |
| authorships[1].author.display_name | Yikang Cheng |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I24943067 |
| authorships[1].affiliations[0].raw_affiliation_string | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China |
| authorships[1].institutions[0].id | https://openalex.org/I24943067 |
| authorships[1].institutions[0].ror | https://ror.org/013q1eq08 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I24943067 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Fudan University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yanlong Cheng |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China |
| authorships[2].author.id | https://openalex.org/A5057210029 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-4812-8842 |
| authorships[2].author.display_name | Zhenghan Qi |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I24943067 |
| authorships[2].affiliations[0].raw_affiliation_string | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China |
| authorships[2].institutions[0].id | https://openalex.org/I24943067 |
| authorships[2].institutions[0].ror | https://ror.org/013q1eq08 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I24943067 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Fudan University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Zhengzhuo Qi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China |
| authorships[3].author.id | https://openalex.org/A5070251359 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-5197-9181 |
| authorships[3].author.display_name | Jing Zhao |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I24943067 |
| authorships[3].affiliations[0].raw_affiliation_string | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China |
| authorships[3].institutions[0].id | https://openalex.org/I24943067 |
| authorships[3].institutions[0].ror | https://ror.org/013q1eq08 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I24943067 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Fudan University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jing Zhao |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China |
| authorships[4].author.id | https://openalex.org/A5100390464 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-2236-4636 |
| authorships[4].author.display_name | Cong Wang |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I24943067 |
| authorships[4].affiliations[0].raw_affiliation_string | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I4210135985 |
| authorships[4].affiliations[1].raw_affiliation_string | Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health Sciences Shanghai 201318 China |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I19820366 |
| authorships[4].affiliations[2].raw_affiliation_string | The Key Laboratory of Biomedical Imaging Science and System Chinese Academy of Sciences State Key Laboratory of Biomedical Imaging Science and System Shenzhen 518055 China |
| authorships[4].institutions[0].id | https://openalex.org/I19820366 |
| authorships[4].institutions[0].ror | https://ror.org/034t30j35 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I19820366 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Chinese Academy of Sciences |
| authorships[4].institutions[1].id | https://openalex.org/I24943067 |
| authorships[4].institutions[1].ror | https://ror.org/013q1eq08 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I24943067 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | Fudan University |
| authorships[4].institutions[2].id | https://openalex.org/I4210135985 |
| authorships[4].institutions[2].ror | https://ror.org/03ns6aq57 |
| authorships[4].institutions[2].type | education |
| authorships[4].institutions[2].lineage | https://openalex.org/I4210135985 |
| authorships[4].institutions[2].country_code | CN |
| authorships[4].institutions[2].display_name | Shanghai University of Medicine and Health Sciences |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Cong Wang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Shanghai Fifth People's Hospital School of Pharmacy MOE Key Laboratory of Smart Drug Delivery MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases Fudan University Shanghai 201203 China, Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health Sciences Shanghai 201318 China, The Key Laboratory of Biomedical Imaging Science and System Chinese Academy of Sciences State Key Laboratory of Biomedical Imaging Science and System Shenzhen 518055 China |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202404857 |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Bio‐Nano Innovations Targeting the Neurovascular Complex for Epilepsy Treatment |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10094 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2738 |
| primary_topic.subfield.display_name | Psychiatry and Mental health |
| primary_topic.display_name | Epilepsy research and treatment |
| related_works | https://openalex.org/W2086998976, https://openalex.org/W2178199374, https://openalex.org/W3043448346, https://openalex.org/W75372167, https://openalex.org/W4381331530, https://openalex.org/W2592432559, https://openalex.org/W2153743757, https://openalex.org/W2097377975, https://openalex.org/W4324330064, https://openalex.org/W4229836497 |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1002/adhm.202404857 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2500736452 |
| best_oa_location.source.issn | 2192-2640, 2192-2659 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 2192-2640 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Advanced Healthcare Materials |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202404857 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Advanced Healthcare Materials |
| best_oa_location.landing_page_url | https://doi.org/10.1002/adhm.202404857 |
| primary_location.id | doi:10.1002/adhm.202404857 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2500736452 |
| primary_location.source.issn | 2192-2640, 2192-2659 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 2192-2640 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Advanced Healthcare Materials |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202404857 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Advanced Healthcare Materials |
| primary_location.landing_page_url | https://doi.org/10.1002/adhm.202404857 |
| publication_date | 2025-04-30 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2596295986, https://openalex.org/W6823583044, https://openalex.org/W2911761011, https://openalex.org/W3200322762, https://openalex.org/W3136455708, https://openalex.org/W6743573185, https://openalex.org/W2077008944, https://openalex.org/W4381331530, https://openalex.org/W6822515240, https://openalex.org/W4381431258, https://openalex.org/W6600478496, https://openalex.org/W4293194614, https://openalex.org/W2121709831, https://openalex.org/W4406018306, https://openalex.org/W4406213658, https://openalex.org/W2191833016, https://openalex.org/W2093729275, https://openalex.org/W4406584509, https://openalex.org/W3208234271, https://openalex.org/W6743267390, https://openalex.org/W3128265017, https://openalex.org/W3092129232, https://openalex.org/W3192989088, https://openalex.org/W4289109292, https://openalex.org/W4214577212, https://openalex.org/W4220970567, https://openalex.org/W4313545547, https://openalex.org/W1577858425, https://openalex.org/W4214744942, https://openalex.org/W6603363112, https://openalex.org/W4307338781, https://openalex.org/W4385827779, https://openalex.org/W4283325889, https://openalex.org/W4385461563, https://openalex.org/W4224097781, https://openalex.org/W2314551501, https://openalex.org/W4400881231, https://openalex.org/W3120690860, https://openalex.org/W3164962077, https://openalex.org/W183086364, https://openalex.org/W4393507463, https://openalex.org/W2235944154, https://openalex.org/W3201061311, https://openalex.org/W2109644106, https://openalex.org/W2081310267, https://openalex.org/W1970117905, https://openalex.org/W2026211597, https://openalex.org/W4292411790, https://openalex.org/W2781955495, https://openalex.org/W3046558836, https://openalex.org/W4376140044, https://openalex.org/W4296087069, https://openalex.org/W4220660628, https://openalex.org/W1214867471, https://openalex.org/W3047765583, https://openalex.org/W4319021446, https://openalex.org/W2022981588, https://openalex.org/W2066564803, https://openalex.org/W3175320898, https://openalex.org/W1501414201, https://openalex.org/W4206090457, https://openalex.org/W2002436505, https://openalex.org/W2595114075, https://openalex.org/W1983100194, https://openalex.org/W6826058279, https://openalex.org/W2002196897, https://openalex.org/W4388486724, https://openalex.org/W3204727461, https://openalex.org/W3156227077, https://openalex.org/W2042393720, https://openalex.org/W2104177694, https://openalex.org/W3111908605, https://openalex.org/W4280538902, https://openalex.org/W3135720699, https://openalex.org/W4393396967, https://openalex.org/W6600120041, https://openalex.org/W2224835203, https://openalex.org/W2803963182, https://openalex.org/W2117643610, https://openalex.org/W3047008573, https://openalex.org/W1989821784, https://openalex.org/W2037125682, https://openalex.org/W6680539271, https://openalex.org/W2794514527, https://openalex.org/W2513833733, https://openalex.org/W1807665039, https://openalex.org/W57616982, https://openalex.org/W4362716666, https://openalex.org/W3091980736, https://openalex.org/W2981085004, https://openalex.org/W2946271004, https://openalex.org/W2775939341, https://openalex.org/W2135808877, https://openalex.org/W1994883271, https://openalex.org/W4395075693, https://openalex.org/W2160779028, https://openalex.org/W2131300789, https://openalex.org/W2060611721, https://openalex.org/W2917725521, https://openalex.org/W2790631595, https://openalex.org/W3052353849, https://openalex.org/W4386084343, https://openalex.org/W3001335228, https://openalex.org/W2061600370, https://openalex.org/W3199174253, https://openalex.org/W2075090887, https://openalex.org/W2071993278, https://openalex.org/W2142660615, https://openalex.org/W4311825607, https://openalex.org/W2147085229, https://openalex.org/W4224091812, https://openalex.org/W3158226187, https://openalex.org/W4397032347, https://openalex.org/W4206389675, https://openalex.org/W4323924011, https://openalex.org/W3091070709, https://openalex.org/W3025062943, https://openalex.org/W4384625933, https://openalex.org/W4404483412, https://openalex.org/W4404766223, https://openalex.org/W4393051507, https://openalex.org/W3043443440, https://openalex.org/W3176266911, https://openalex.org/W4386295512, https://openalex.org/W4220824158, https://openalex.org/W6601048975, https://openalex.org/W2972804872, https://openalex.org/W2790816472, https://openalex.org/W4364352447, https://openalex.org/W4399802920, https://openalex.org/W4298127491, https://openalex.org/W4389151992, https://openalex.org/W6600753396, https://openalex.org/W4328048557, https://openalex.org/W2995981280, https://openalex.org/W6636223485, https://openalex.org/W4396673146, https://openalex.org/W4402515754, https://openalex.org/W4377223843, https://openalex.org/W2142159176, https://openalex.org/W4388638734, https://openalex.org/W6600274734, https://openalex.org/W3177046783, https://openalex.org/W3142424589, https://openalex.org/W3011486289, https://openalex.org/W6629813396, https://openalex.org/W4386056853, https://openalex.org/W3048507916, https://openalex.org/W4313857806, https://openalex.org/W3096808959, https://openalex.org/W4320919557, https://openalex.org/W3088014179, https://openalex.org/W4313898132, https://openalex.org/W2344969217, https://openalex.org/W2047530387, https://openalex.org/W3027873430, https://openalex.org/W4281477553, https://openalex.org/W3005554048, https://openalex.org/W2612893831, https://openalex.org/W3128094128, https://openalex.org/W2795953388, https://openalex.org/W2090309041, https://openalex.org/W6610928041, https://openalex.org/W2795299846, https://openalex.org/W2989515402, https://openalex.org/W4212900099, https://openalex.org/W2345829405, https://openalex.org/W4365816135, https://openalex.org/W2902701280, https://openalex.org/W2968121467, https://openalex.org/W4396828320, https://openalex.org/W4394875618, https://openalex.org/W4296260543, https://openalex.org/W4388850963, https://openalex.org/W4381053316, https://openalex.org/W4401478045, https://openalex.org/W4390546700, https://openalex.org/W2064161366, https://openalex.org/W4399117456, https://openalex.org/W4206965632, https://openalex.org/W4225620981 |
| referenced_works_count | 181 |
| abstract_inverted_index.a | 3, 51 |
| abstract_inverted_index.an | 13 |
| abstract_inverted_index.be | 166 |
| abstract_inverted_index.by | 9, 100 |
| abstract_inverted_index.in | 66, 106, 150 |
| abstract_inverted_index.is | 2, 135 |
| abstract_inverted_index.it | 110 |
| abstract_inverted_index.of | 71, 128, 182 |
| abstract_inverted_index.to | 82, 131, 178 |
| abstract_inverted_index.NVC | 104, 130 |
| abstract_inverted_index.The | 126 |
| abstract_inverted_index.and | 17, 39, 69, 89, 123, 147, 161, 185 |
| abstract_inverted_index.are | 153, 172 |
| abstract_inverted_index.for | 50, 62, 158, 168, 193 |
| abstract_inverted_index.has | 59 |
| abstract_inverted_index.its | 63 |
| abstract_inverted_index.key | 114 |
| abstract_inverted_index.the | 23, 47, 55, 67, 87, 94, 102, 116, 124, 156, 162, 180 |
| abstract_inverted_index.aims | 177 |
| abstract_inverted_index.core | 103 |
| abstract_inverted_index.down | 111 |
| abstract_inverted_index.drug | 36, 84 |
| abstract_inverted_index.four | 113 |
| abstract_inverted_index.from | 12 |
| abstract_inverted_index.have | 78 |
| abstract_inverted_index.high | 35 |
| abstract_inverted_index.into | 112 |
| abstract_inverted_index.more | 183 |
| abstract_inverted_index.must | 165 |
| abstract_inverted_index.only | 41 |
| abstract_inverted_index.poor | 32 |
| abstract_inverted_index.role | 65 |
| abstract_inverted_index.than | 45 |
| abstract_inverted_index.that | 164 |
| abstract_inverted_index.this | 97, 175 |
| abstract_inverted_index.(NVC) | 58 |
| abstract_inverted_index.Next, | 137 |
| abstract_inverted_index.While | 20 |
| abstract_inverted_index.brain | 33, 88 |
| abstract_inverted_index.cure. | 53 |
| abstract_inverted_index.faces | 28 |
| abstract_inverted_index.glial | 121 |
| abstract_inverted_index.guide | 179 |
| abstract_inverted_index.their | 142 |
| abstract_inverted_index.(BBB), | 119 |
| abstract_inverted_index.across | 86 |
| abstract_inverted_index.begins | 99 |
| abstract_inverted_index.causes | 49 |
| abstract_inverted_index.cells, | 122 |
| abstract_inverted_index.design | 143 |
| abstract_inverted_index.enable | 90 |
| abstract_inverted_index.gained | 60 |
| abstract_inverted_index.rates, | 38 |
| abstract_inverted_index.rather | 44 |
| abstract_inverted_index.review | 98, 176 |
| abstract_inverted_index.within | 93 |
| abstract_inverted_index.Herein, | 96 |
| abstract_inverted_index.barrier | 118 |
| abstract_inverted_index.between | 15 |
| abstract_inverted_index.chronic | 5 |
| abstract_inverted_index.complex | 57 |
| abstract_inverted_index.enhance | 83 |
| abstract_inverted_index.improve | 132 |
| abstract_inverted_index.lesion. | 95 |
| abstract_inverted_index.precise | 91, 186 |
| abstract_inverted_index.relief, | 43 |
| abstract_inverted_index.remains | 22 |
| abstract_inverted_index.systems | 77 |
| abstract_inverted_index.therapy | 134, 152 |
| abstract_inverted_index.various | 74 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Epilepsy | 1 |
| abstract_inverted_index.Finally, | 155 |
| abstract_inverted_index.Overall, | 174 |
| abstract_inverted_index.breaking | 109 |
| abstract_inverted_index.clinical | 170 |
| abstract_inverted_index.critical | 64 |
| abstract_inverted_index.delivery | 85 |
| abstract_inverted_index.designed | 81 |
| abstract_inverted_index.disorder | 7 |
| abstract_inverted_index.emerged, | 79 |
| abstract_inverted_index.epilepsy | 107, 133, 151, 194 |
| abstract_inverted_index.involved | 105 |
| abstract_inverted_index.neurons, | 120 |
| abstract_inverted_index.neurons. | 19 |
| abstract_inverted_index.outcomes | 192 |
| abstract_inverted_index.overcome | 167 |
| abstract_inverted_index.seizures | 10 |
| abstract_inverted_index.standard | 24 |
| abstract_inverted_index.systems, | 140 |
| abstract_inverted_index.Recently, | 54 |
| abstract_inverted_index.analyzed. | 136 |
| abstract_inverted_index.attention | 61 |
| abstract_inverted_index.detailing | 141 |
| abstract_inverted_index.effective | 169 |
| abstract_inverted_index.efficient | 184 |
| abstract_inverted_index.enhancing | 190 |
| abstract_inverted_index.epilepsy. | 72 |
| abstract_inverted_index.imbalance | 14 |
| abstract_inverted_index.including | 31 |
| abstract_inverted_index.outlining | 101 |
| abstract_inverted_index.patients. | 195 |
| abstract_inverted_index.prevalent | 4 |
| abstract_inverted_index.prospects | 157 |
| abstract_inverted_index.providing | 40 |
| abstract_inverted_index.resulting | 11 |
| abstract_inverted_index.targeting | 92, 129 |
| abstract_inverted_index.treatment | 191 |
| abstract_inverted_index.viability | 127 |
| abstract_inverted_index.addressing | 46 |
| abstract_inverted_index.bio‐nano | 187 |
| abstract_inverted_index.challenges | 163 |
| abstract_inverted_index.discussed. | 173 |
| abstract_inverted_index.excitatory | 16 |
| abstract_inverted_index.inhibitory | 18 |
| abstract_inverted_index.innovative | 75, 138 |
| abstract_inverted_index.resistance | 37 |
| abstract_inverted_index.therapies, | 188 |
| abstract_inverted_index.treatment, | 25, 108 |
| abstract_inverted_index.ultimately | 189 |
| abstract_inverted_index.underlying | 48 |
| abstract_inverted_index.challenges, | 30 |
| abstract_inverted_index.components: | 115 |
| abstract_inverted_index.development | 68, 181 |
| abstract_inverted_index.evaluations | 149 |
| abstract_inverted_index.preclinical | 148 |
| abstract_inverted_index.principles, | 144 |
| abstract_inverted_index.progression | 70 |
| abstract_inverted_index.significant | 29 |
| abstract_inverted_index.strategies, | 146 |
| abstract_inverted_index.symptomatic | 42 |
| abstract_inverted_index.traditional | 26 |
| abstract_inverted_index.translation | 171 |
| abstract_inverted_index.construction | 145 |
| abstract_inverted_index.highlighted. | 154 |
| abstract_inverted_index.neurological | 6 |
| abstract_inverted_index.penetration, | 34 |
| abstract_inverted_index.specifically | 80 |
| abstract_inverted_index.blood‐brain | 117 |
| abstract_inverted_index.characterized | 8 |
| abstract_inverted_index.comprehensive | 52 |
| abstract_inverted_index.neurovascular | 56 |
| abstract_inverted_index.Simultaneously, | 73 |
| abstract_inverted_index.pharmacotherapy | 21, 27 |
| abstract_inverted_index.nanotechnologies | 160 |
| abstract_inverted_index.microenvironment. | 125 |
| abstract_inverted_index.next‐generation | 159 |
| abstract_inverted_index.bio‐nanotechnology | 76, 139 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| citation_normalized_percentile.value | 0.20216146 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |