Bioscaffold guidance drives liver periportal area tubulogenesis in hIPSC organoids Article Swipe
Harini Rajendiran
,
Flavie Luciani
,
Selma Serhrouchni
,
Anais Monet
,
Hui Ting Ong
,
Jin Zhu
,
Piyush Mishra
,
Marion Marchand
,
Geetika Sahni
,
Aditya Arora
,
Mui Hoon Nai
,
Matt S. Hepburn
,
Jiayue Li
,
Alireza Mowla
,
Farzaneh Navaeipour
,
Brendan J. Kennedy
,
Virgile Viasnoff
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.28.672864
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.28.672864
Recapitulating the liver periportal area in vitro remains a major challenge due to its complex cellular composition and the coordinated development of both ductal and endothelial networks. Most existing bile duct organoid models fail to reproduce tubular extension and multicellular organization. We present a 3D ECM micro-rods system biofunctionalized with grafted growth factors mimicking fetal liver paracrine signaling to initiate and to coordinate the development of bile ducts, parenchymal cells, and vascular structures. Our system recapitulates key developmental stages, from the formation of the ductal plate to the emergence of elongated tubular ducts. The ECM rod alone provides the biophysical cues initiating the elongation of the bile ducts and the spatial structuration of the cellular organization, while the biofunctionalization with growth factors enhance the organization and maturation of the biliary and vascular systems. We further demonstrate that this approach is scalable and amenable to quantitative analysis through label-free Optical Coherence Tomography combined with AI-driven 3D segmentation.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.08.28.672864
- https://www.biorxiv.org/content/biorxiv/early/2025/09/02/2025.08.28.672864.full.pdf
- OA Status
- green
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413910776
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413910776Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.08.28.672864Digital Object Identifier
- Title
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Bioscaffold guidance drives liver periportal area tubulogenesis in hIPSC organoidsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-09-02Full publication date if available
- Authors
-
Harini Rajendiran, Flavie Luciani, Selma Serhrouchni, Anais Monet, Hui Ting Ong, Jin Zhu, Piyush Mishra, Marion Marchand, Geetika Sahni, Aditya Arora, Mui Hoon Nai, Matt S. Hepburn, Jiayue Li, Alireza Mowla, Farzaneh Navaeipour, Brendan J. Kennedy, Virgile ViasnoffList of authors in order
- Landing page
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https://doi.org/10.1101/2025.08.28.672864Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2025/09/02/2025.08.28.672864.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2025/09/02/2025.08.28.672864.full.pdfDirect OA link when available
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Organoid, Bile duct, Cell biology, Architecture, Chemistry, Biology, Internal medicine, Medicine, Art, Visual artsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
- References (count)
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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