Biosponge‐Armored Nanodots Restore Redox‐Calcium Homeostasis to Mitigate Reperfusion‐Induced Injury in Ischemic Stroke Article Swipe
Xinyue Cao
,
Ke Shuai
,
Peng Wang
,
Jiacheng Xu
,
Wenqi Pan
,
Ying Wang
,
Xiaoyan Li
,
Weiping Lu
,
Kai Chen
,
Yu Chen
,
Bingcang Huang
,
Liang Chen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adfm.202503183
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adfm.202503183
Antioxidant nanomaterials demonstrate significant neuroprotective potential in mitigating reperfusion injury associated with ischemic stroke. However, emerging nanocatalytic strategies targeting oxidative stress suffer from limited therapeutic efficacy owing to their reliance on singular mechanisms of action. In this study, ultrasmall iridium (Ir)‐based catalytic nanodots encapsulated in biopolymers (HIr‐PS) are developed to address ischemic stroke by concurrently normalizing redox and calcium homeostasis. The engineered HIr‐PS is found to possess multiple antioxidant enzyme‐mimetic activities and exhibits superior reactive oxygen species (ROS)‐scavenging efficacy compared to that of bare Ir and IrO 2 nanodots. Surface‐functionalized biopolymers act as sponges to selectively sequester excess intracellular calcium through coordination interactions. This dual function enables HIr‐PS to protect neuronal cells from oxidative stress, restore mitochondrial function, and alleviate endoplasmic reticulum stress. Consequently, HIr‐PS treatment promotes neuronal survival and remodels the pro‐inflammatory microenvironment, as validated in a mouse model of middle cerebral artery occlusion. Mechanistically, these effects are attributed to the abilities of HIr‐PS to penetrate the blood–brain barrier and disrupt the vicious loop of ROS overproduction and calcium overload. This study presents a distinct paradigm for biopolymer‐coated ultrasmall catalytic nanodots as a non‐pharmaceutical neuroprotective strategy for ischemic stroke treatment.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adfm.202503183
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adfm.202503183
- OA Status
- bronze
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411610039
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411610039Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/adfm.202503183Digital Object Identifier
- Title
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Biosponge‐Armored Nanodots Restore Redox‐Calcium Homeostasis to Mitigate Reperfusion‐Induced Injury in Ischemic StrokeWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-06-24Full publication date if available
- Authors
-
Xinyue Cao, Ke Shuai, Peng Wang, Jiacheng Xu, Wenqi Pan, Ying Wang, Xiaoyan Li, Weiping Lu, Kai Chen, Yu Chen, Bingcang Huang, Liang ChenList of authors in order
- Landing page
-
https://doi.org/10.1002/adfm.202503183Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adfm.202503183Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adfm.202503183Direct OA link when available
- Concepts
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Materials science, Redox, Calcium, Homeostasis, Nanodot, Stroke (engine), Ischemia, Biophysics, Nanotechnology, Internal medicine, Medicine, Biology, Metallurgy, Engineering, Mechanical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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58Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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