Bleeding and thrombosis outcomes in hospitalised COVID-19 patients on low-molecular-weight heparin and antiplatelet therapy Article Swipe
Veshni Pillay-Fuentes Lorente
,
Roland van Rensburg
,
Muhammad Moolla
,
Michael McCaul
,
Angela Parker
,
Jantjie Taljaard
,
Helmuth Reuter
,
Eric Decloedt
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7196/samj.2022.v112i7.16434
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7196/samj.2022.v112i7.16434
Background. An increased incidence of thromboembolic events in hospitalised COVID‐19 patients has been demonstrated despite the use of low‐molecular‐weight heparin (LMWH). Antiplatelet therapy prior to admission and early in the disease course has been hypothesised to be protective against thrombosis.Objectives. To describe the bleeding and thrombosis outcomes in hospitalised patients with confirmed COVID‐19 receiving LMWH, with and without concomitant antiplatelet therapy. Secondary objectives were to explore predictors of bleeding and thrombosis outcomes, and dosing practices of antiplatelet therapy and LMWH. Methods. We conducted a descriptive, cross‐sectional study of bleeding and thrombosis outcomes at Tygerberg Academic Hospital, Cape Town, South Africa, during the first COVID‐19 wave, in 808 hospitalised patients with confirmed COVID‐19 receiving LMWH with and without concomitant antiplatelet therapy. Multivariate logistic regression analysis was performed if predictors were deemed statistically and clinically significant. Results. Patients receiving both LMWH and antiplatelet therapy had similar bleeding outcomes compared with patients only receiving LMWH (odds ratio (OR) 1.5; 95% confidence interval (CI) 0.6 ‐ 4.0). Patients receiving both LMWH and antiplatelet therapy had increased odds of developing thrombosis compared with patients only receiving LMWH (OR 4.8; 95% CI 2.1 ‐ 10.7).Conclusion. The bleeding risk in COVID‐19 patients receiving both LMWH and antiplatelet therapy was not significantly increased. A potentially higher risk of thrombosis in patients receiving LMWH and antiplatelet therapy was observed. However, this could reflect confounding by indication. Randomised studies are required to further evaluate the use of antiplatelet therapy to treat hospitalised patients with COVID‐19.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7196/samj.2022.v112i7.16434
- https://samajournals.co.za/index.php/samj/article/download/472-476/9
- OA Status
- gold
- Cited By
- 1
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4286636714
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4286636714Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7196/samj.2022.v112i7.16434Digital Object Identifier
- Title
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Bleeding and thrombosis outcomes in hospitalised COVID-19 patients on low-molecular-weight heparin and antiplatelet therapyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-07-01Full publication date if available
- Authors
-
Veshni Pillay-Fuentes Lorente, Roland van Rensburg, Muhammad Moolla, Michael McCaul, Angela Parker, Jantjie Taljaard, Helmuth Reuter, Eric DecloedtList of authors in order
- Landing page
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https://doi.org/10.7196/samj.2022.v112i7.16434Publisher landing page
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https://samajournals.co.za/index.php/samj/article/download/472-476/9Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://samajournals.co.za/index.php/samj/article/download/472-476/9Direct OA link when available
- Concepts
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Medicine, Low molecular weight heparin, Odds ratio, Thrombosis, Concomitant, Internal medicine, Confidence interval, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2023: 1Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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