Blind Spot for Sedentarism: Redefining the Diseasome of Physical Inactivity in View of Circadian System and the Irisin/BDNF Axis Article Swipe
Judit Zsuga
,
Csaba E. Móré
,
Tamás Erdei
,
Csaba Papp
,
Szilvia Harsányi
,
Rudolf Gesztelyi
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2018.00818
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2018.00818
Introduction: The term "diseasome of physical inactivity" was coined by Pedersen to explain clustering of chronic diseases linked to physical inactivity. Accordingly, physical inactivity per se contributes to the accumulation of visceral fat, which, generates chronic low-grade systemic inflammation, contributes to emergence of chronic, non-communicable diseases. Diversity of these disorders posits the possible involvement of a supraphysiological system. Methods: Hypothesis driven literature search and deductive reasoning was used to review relevant literature and formulate a novel theory. Results: We have identified the circadian system, omnipresent in virtually every cell, as a possible vehicle for brain muscle crosstalk, explaining some aspects of the diseasome of physical inactivity This system is hierarchically organized, with the suprachiasmatic nucleus (SCN) being the master clock that entrains to the dark/light cycle and synchronizes subsidiary molecular clocks in the periphery. Insufficient photic entrainment also causes chronic disease evolution. The recently identified irisin, was shown to induce brain-derived neurotrophic factor (BDNF) production in several brain areas. BDNF assumes significant role in gating light's influence in the retinohypothalamic synapse, by having a permissive effect on glutamate signal transduction underlying photic entrainment. Conclusions: Here we provide theoretical evidence to support the hypothesis that irisin may facilitate photic entrainment of the SCN, via BDNF. By this irisin opens up possible pathways for peripheral non-photic entrainment signals to exert influence on the master clock that is otherwise resistant to these. Furthermore, we suggest that intertwining processes of circadian, redox, inflammatory, and myokine systems lay underneath the diseasome of physical inactivity.
Related Topics
Concepts
Suprachiasmatic nucleus
Neuroscience
Circadian rhythm
Myokine
Neurotrophic factors
Biology
Endocrinology
Circadian clock
Light effects on circadian rhythm
Internal medicine
Medicine
Skeletal muscle
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fneur.2018.00818
- https://www.frontiersin.org/articles/10.3389/fneur.2018.00818/pdf
- OA Status
- gold
- Cited By
- 13
- References
- 129
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2889874748
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2889874748Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fneur.2018.00818Digital Object Identifier
- Title
-
Blind Spot for Sedentarism: Redefining the Diseasome of Physical Inactivity in View of Circadian System and the Irisin/BDNF AxisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-10-01Full publication date if available
- Authors
-
Judit Zsuga, Csaba E. Móré, Tamás Erdei, Csaba Papp, Szilvia Harsányi, Rudolf GesztelyiList of authors in order
- Landing page
-
https://doi.org/10.3389/fneur.2018.00818Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fneur.2018.00818/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fneur.2018.00818/pdfDirect OA link when available
- Concepts
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Suprachiasmatic nucleus, Neuroscience, Circadian rhythm, Myokine, Neurotrophic factors, Biology, Endocrinology, Circadian clock, Light effects on circadian rhythm, Internal medicine, Medicine, Skeletal muscle, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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13Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 2, 2023: 3, 2022: 1, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
129Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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